1UO1DE018902, S Engebretson (PI) 07/21/2008 – 07/20/2013
NIH/NIDCR
Project Title: Diabetes and Periodontics Trial
The major goal of this study is to determine if non-surgical periodontal therapy reduces HbA1c levels in patients with type 2 diabetes and periodontitis.
Role: Site PI

1R21DE018717, R Gopalakrishnan (PI) 08/0120/10 – 07/31/2012
NIH/NIDCR
Project Title: Periodontal disease as a risk factor for ONJ
The major aims of the study are to: (a) To determine the association between clinical and microbiological measures of periodontitis and risk of ONJ development. (b) To determine whether ONJ is associated with increased mucosal invasion of putative periodontal pathogens and Actinomyces species
Role: Co-investigator

AHC (UIMN) Faculty Development Grant
B Michalowicz & J Molitor (co-PIs) 01/01/2010 – 12/31/2011
Project title: Prognostic Utility of Periodontal Disease in Rheumatoid Arthritis
The major aims of this study are to determine if moderate to advanced periodontitis and the bacterium Porphyromonas gingivalis are associated with anti-CCP antibodies in shared epitope-positive, non-rheumatoid arthritis patients.
Role: Co-PI

Case Western Reserve University Alumni Scholarship, 1977-1981

Balint Orban Award for outstanding graduate research, American Academy of Periodontology, 1988

Diplomate, American Board of Periodontology, 1991

Omicron Kappa Upsilon Honorary Dental Fraternity, 1993

Invited Participant, American Academy of Periodontology World Workshop in Periodontics, 1996

Clinical Research Award, American Academy of Periodontology, 2001, 2007

Michalowicz, BS, Hodges JS, Lussky RC, Bada H, Rawson T, Buttross LS, Chiriboga C, DiAngelis AJ, Novak MJ, Buchanan W, Mitchell DA, Papapanou PN. Maternal Periodontitis Treatment and Child Neurodevelopment at 24-28 Months of Age, Pediatrics, April 2011;127:e1212–e1220

Lockhart PB, Brennan MT, Thornhill M, Michalowicz BS, Noll J, Bahrani-Mougeot FK, Sasser HC. Poor oral hygiene as a risk factor for infective endodcarditis-related bacteremia. J Am Dent Assoc 140(10):1238-44, 2009.

Michalowicz BS Novak MJ, Hodges JS, DiAngelis A, Buchanan W, Papapanou PN, Mitchell DA, Ferguson II JE, Lupo V, Bofill J, Matseoane S, Steffen M, Ebersole JL. Serum Inflammatory Mediators in Pregnancy: Changes Following Periodontal Treatment and Association with Pregnancy Outcomes, J Periodontol 80(11):1731-41, 2009.

Thumbigere-Math V, Sabino MC, Gopalakrishnan R, Huckabay S, Dudek AZ, Basu S, Hughes PJ, Michalowicz BS, Leach JW, Swenson KK, Swift JQ, Adkinson C, Basi DL. Bisphosphonate-Associated Osteonecrosis of the Jaw. J Oral MaxillofacSurg 67(9): 1904-13, 2009.

Wolff RE, Wolff, LF, Michalowicz BS. A Pilot Study of the Relationship between Periodontitis and HbA1c in Non-diabetics. J Periodontol 80(7): 1057-61, 2009.

Durand R, Gunselman EL, Hodges JS, DiAngelis AJ, Michalowicz B. A pilot study of the association between cariogenic oral bacteria and preterm birth. Oral Dis 15(6):400-6, 2009. Epub 2009 Apr 8.

Ebersole JL, Novak MJ, Michalowicz BS, Hodges JS, Steffen MJ, Ferguson JE, DiAngelis AJ, Buchanan W, Mitchell DA, Papapanou PN. Systemic Immune Responses in Pregnancy and Periodontitis: Relationship to Pregnancy Outcomes and Treatment in the OPT Study, J Periodontol 80: 953-960, 2009.

Michalowicz BS, Hodges JS, Novak MJ, Buchanan W, DiAngelis AJ, Papapanou PN, Mitchell DA, Ferguson JE, Lupo VR, Bofill J, Matseoane S. Change in Periodontitis during Pregnancy and Risk of Preterm Birth and Low Birthweight, J Clin Periodontol 36(4): 308-314, 2009.

B. Selected peer-reviewed publications (since 2000)

Michalowicz BS, DiAngelis AJ, Lupo VR, Novak MJ, Ferguson JE, Buchanan W, Bofill J, Papapanou PN, Mitchell DA, Matseoane S, Curran A, Deinard Jr AS, Rogers TB. Examining the Safety of Dental Treatment in Pregnant Women. J Am Dent Assoc 139(6):685-95, 2008.

Stoltenberg JL, Osborn JB, Carlson JF, Hodges JS, Michalowicz BS. A Preliminary Study of Intra-pocket Topical versus Injected Anesthetic for Scaling and Root Planing, J Clin Periodontol 34(10): 892-6, 2007.

Madden R, Hodges JS, Salmen CW, Rindal BD, Tunio J, Michalowicz BS, Ahmad M. Utility of Panoramic Radiographs in Detecting Cervical Calcified Carotid Atheroma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103(4): 543-8, 2007.

Michalowicz BS, Durand R. Maternal Periodontal Disease and Spontaneous Preterm Birth. Periodontology 2000, 44: 103-12, 2007.

Michalowicz BS, Hodges JS, DiAngelis AJ, Lupo VR, Novak MJ, Ferguson JE, Buchanan W, Bofill J, Papapanou PN, Mitchell DA, Matseoane S, Tschida PA; OPT Study. Treatment of periodontal disease and the risk of preterm birth. N Engl J Med 355(18): 1885-94, 2006.

Wohlfahrt JC, Wu T, Hodges J, Hinrichs JE, Michalowicz BS. No Association between Selected Candidate Gene Polymorphisms and Severe Chronic Periodontitis. J Periodontol, 77(3): 426-36, 2006.

Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal Diseases. Lancet 366(9499): 1809-20, 2005.

Rhodus NL, Michalowicz BS. Periodontal status and sulcular Candida albicans colonization in patients with primary Sjögren’s Syndrome. Quintessence Int, 36: 228-232, 2005

Diehl SR, Wu T, Michalowicz BS, Brooks CN, Califano JV, Burmeister JA, Schenkein HA. Quantitative Measures of Aggressive Periodontitis Show Substantial Heritability and Consistency with Traditional Diagnoses. J Periodontol, 76: 279-288, 2005.

Ginos MA, Page GP, Michalowicz BS, Patel KJ, Volker SE, Pambuccian SE, Ondrey FG, Adams GL, Gaffney PM. Identification of a Gene Expression Signature Associated with Recurrent Disease in Squamous Cell Carcinoma of the Head and Neck. Cancer Research 64: 55–63, 2004.

Preshaw PM, Hefti AF, Novak MJ, Michalowicz BS, Pihlstrom BL, Schoor R, Trummel CL, Van Dyke TE, Walker CB, Bradshaw MH. Subantimicrobial Dose Doxycycline Enhances the Efficacy of Scaling and Root Planing in Chronic Periodontitis: A Multicenter Trial. J Periodontol 75: 1068-76, 2004.

Hodge P, Michalowicz B. Genetic predisposition to periodontitis in children and young adult (Review) Periodontology 2000 26: 113-134, 2001.

Michalowicz BS, Pihlstrom BL, Hodges JS, Bouchard TJ Jr. No heritability of temporomandibular joint area signs and symptoms. J Dent Res 79(8): 1573-1578, 2000.

Contreras A, Rusitanonta T, Chen C, Wagner W G, Michalowicz BS, Slots J. Frequency of 530-bp deletion in Actinobacillus actinomycetemcomitans leukotoxin promoter region. Oral Microbiol Immunol 15: 338-340, 2000.

Michalowicz BS, Ronderos M, Cámara-Silva R, Contreras A, Slots J. Human herpesviruses and Porphyromonas gingivalis are associated with juvenile periodontitis. J Periodontol 71(6): 981-988, 2000

Michalowicz, BS, Diehl, SR, Gunsolley, JC, Sparkes, B, Brooks, CN, Koertge, TE, Califano, JE, Burmeister, JA, Schenkein, HA. Evidence of a substantial genetic basis for risk of adult periodontitis, J Periodontol 71: 1699-1707, 2000.

Diplomate, American Board of Periodontology, 1991