Conrado Aparicio

Conrado Aparicio

Academic Title

Associate Professor
Division of Biomaterials
Department of Restorative Sciences
Deputy Director of the Minnesota Dental Research Center for Biomaterials and Biomechanics

Education

Master's
Materials Engineering, MScEng, Technological Univ. Catalonia (Spain), 1998
Ph.D.
Biomaterials, Ph.D., Technological Univ. Catalonia (Spain), 2004
Other Education
Regenerative Medicine, Post Doc, Northwestern University, 2007

Contact Info

Email
apari003@umn.edu

Phone
612-625-4467

Fax
612-626-1484

Office Address

16-250A Moos Tower
515 Delaware St. SE
Minneapolis, MN 55455

Bio Statement

Dr Conrado Aparicio is an investigator with a research focus on the surfaces of dental biomaterials, their design, modification, as well as the characterization and analysis of their physical, chemical, mechanical, and biological properties. He is a materials engineer by training and performed my PhD under the supervision of Professor Javier Gil at BarcelonaTech-UPC developing new surface treatments to improve osseointegration of dental implants.

After getting his position as a senior lecturer in Spain, Dr Aparicio moved to Chicago where he was a visiting scholar at the Institute for BioNanotechnology in Medicine of Northwestern University under the supervision of Professor Samuel Stupp. Dr Aparicio investigated the biomineralization of self-assembled nanostructured scaffolds made of peptide-amphiphiles.

Dr Aparicio’s main subjects of research are the understanding of the interactions between biological and synthetic materials, biofunctionalization of surfaces with synthetic biomolecules for improving bioactivity and antimicrobial properties of different dental biomaterials, and biomineralization of biomaterials.

Moreover, since Dr Aparicio arrived at the University of Minnesota his research interests expanded to studying and developing new techniques and new biomaterials, including 1) dental restorative materials and biological agents to induce bone regeneration and teeth remineralization; and 2) new methodologies for the assessment and management of dental biofilms.

Dr Aparicio’s background and record of scholarly publications reflects a multi- and interdisciplinary approach to biomaterials and biomechanics science and engineering, including several biomolecular, in vitro and in vivo studies.

Research Interests

 

  • Surface modification of metals for dental and orthopedic implants
  • Biomineralization of synthetic materials and tissues
  • Biomimetic systems for biomedical applications
  • Development and evaluation of dental restorative materials
  • Regeneration of hard tissues (enamel, dentin, bone)\
  • Dental biofilms
  • Synthetic peptides and self-assembly

 

Leadership Roles

Course Director

DDS 6411 – Applied Dental Biomaterials
DT 3410/5410 – Applied Dental Biomaterials
OBIO 8027 - Biomaterials for Regenerative Medicine. A Focus on Dentistry
DENT 7411 - Dental Biomaterials in Prosthodontics

Other teaching assignments

OBIO 8030 - Physical Biology of the Oral Cavity (Invited lecturer)
PASS Program – Dental Materials (Lecturer)
BMEn 5001 – Advanced Biomaterials (Invited Lecturer)
DENT 8101 – Implantology (Invited Lecturer)

 

Awards

2013 Paper of the Year Award (Basic Sciences). University of Minnesota School of Dentistry

2012 9th World Biomaterials Congress, Rapid-Fire Poster Presentation Award

2009 3M Non-tenured Faculty Award

2004/2005 Best PhD Dissertation in Chemistry or Materials Science in Spain

2006 City of Barcelona Award for Technological Research

2005 European Basic Research in Odontology Award

Catalan Government Post-doctoral Fellowship

Fulbright Post-doctoral Fellowship

2002 J Mat Sci: Mater Med Best Paper Award

Best Young Scientist Oral Presentation at SIB

Spanish Ministry Graduate Fellowship

Publications

X. Chen, H. Hirt, Y. Li, S.-U. Gorr, C. Aparicio. Antimicrobial GL13K peptide coatings killed and ruptured the wall of Streptococcus gordonii and prevented formation and growth of biofilms. PLOS ONE (2014). 9(11):e11579.

 

N. Marín-Pareja, E. Salvagni, J. Guillem-Marti, C. Aparicio, M.P. Ginebra. Collagen-functionalized titanium surfaces for biological sealing of dental implants: Effect of immobilization process on fibroblasts response. Colloids and Surfaces B: Biointerfaces (2014) 122:601-610.

Y. Li, X. Chen, A. Ribeiro, E. Jensen, K.H. Holmberg. J.C. Rodriguez-Cabello, C. Aparicio. Hybrid nanotopographic surfaces obtained by biomimetic mineralization of statherin-inspired elastin-like recombinamers. Advanced Healthcare Materials (2014) 3:1638-1647.

E. Salvagni, G.Y. Berguig, E. Engel, J.C. Rodriguez-Cabello, G. Coullerez, M. Textor, F.J. Gil, J.A. Planell, C. Aparicio. A bioactive elastin-like recombinamer reduces unspecific protein adsorption and enhances cell response on titanium surfaces. Colloids and Surfaces B: Biointerfaces (2014) 114: 225-233.

Y. Li, C. Carrera, R. Chen, J. Li, P. Lenton, J.D. Rudney, R.S. Jones, C. Aparicio, A. Fok. Interfacial Degradation in Composite Restorations Subjected to Multi-Species Biofilm Challenges. Acta Biomaterialia (2014) 10:375-383.

D. Isfeld, C. Aparicio, R.S. Jones. Assessing near Infrared Optical Properties of Ceramic Orthodontic Brackets using Cross-Polarization Optical Coherence Tomography. Journal of Biomedical Materials Research B (2014) 102:516-523.

F.J. Gil, N. Manzanares, A. Badet, C. Aparicio, M.P. Ginebra. Biomimetic Treatment of Dental Implants for Short-Term Bone Regeneration. Clinical Oral Investigations (2014) 18:59-66.

Y. Li, C. Aparicio. Visualizing the subfibrillar structure of mineralized collagen fibrils: A model of the ultrastructure of bone. PLoS ONE (2013) 8(9): e76782.

K.V. Holmberg, M. Abdolhosseini, X. Chen, E. Jensen, Y. Li, S.-U. Gorr, C. Aparicio. Bio-inspired Antimicrobial Peptide Coating for Dental Implants. Acta Biomaterialia (2013) 9(9): 8224-31.

G. Mestres, M. Abdholosseini, W. Bowles, C. Aparicio, S.-U. Gorr, M.P. Ginebra. Dentin bonding strength and antimicrobial properties of magnesium phosphate cements for endodontic applications. Acta Biomaterialia (2013) 9(9):8384-93.

X. Chen, P. Sevilla, C. Aparicio. Surface biofunctionalization by covalent co-immobilization of oligopeptides. Colloids and Surfaces B: Biointerfaces. (2013) 107:189-97.

J.D. Rudney, R. Chen, P. Lenton, J. Li, Y. Li, R.S. Jones, C. Reilly, A.S. Fok, C. Aparicio. Reproducible Oral Microcosm Biofilm Model for Testing Dental Materials Journal of Applied Microbiology (2012) 113(6):1540-53.

M. Pegueroles, Ch. Tonda, E. Engel, J.A. Planell, C. Aparicio. Adsorption of fibronectin, fibrinogen, and albumin on TiO2: time-resolved kinetics, structural changes, and competition study. Biointerphases (2012) 7:48.

P. Lenton, J. Rudney, R. Chen, A. Fok, C. Aparicio, R.S. Jones. Imaging in vivo secondary caries and ex vivo dental biofilms using cross-polarization optical coherence tomography. Dental Materials (2012) 28(7):792-800.

R. Chen, J. Rudney, C. Aparicio, A. Fok, R.S. Jones. Quantifying dental biofilm growth using cross-polarization optical coherence tomography. Letters in Applied Microbiology (2012) 54:537–542.

S.-H. Huang, L.-S. Lin, J. Rudney, R.S. Jones, C. Aparicio, C.-P. Lin, A.S.L. Fok A novel dentin bond strength measurement technique using the composite disk in diametral compression. Acta Biomaterialia (2012) 8(4):1597-1602.

Y. Li, T.T. Thula, S. Jee, S.L. Perkins, C. Aparicio, E.P. Douglas, L.B. Gower. Biomimetic Mineralization of Woven Bone-Like Nanocomposites: Role of Collagen Cross-Links. Biomacromolecules (2012) 13:49-59.

C. Aparicio, A. Padros, F.J. Gil. In vivo evaluation of Micro-Rough and Bioactive Titanium Dental Implants using Histometry and Pull-Out Tests. Journal of the Mechanical Behavior of Biomedical Materials (2011) 4:1672-1682.

W.-J. Seong, H.-C. Kim, S. Jeong, D.L. DeVeau, C. Aparicio, Y. Li, J.S. Hodges. Ex vivo mechanical properties of dental implant bone cement used to rescue initially unstable dental implants at first-stage surgery: A rabbit study. International Journal of Oral and Maxillofacial Implants (2011) 26:826-836.

M. Pegueroles, A. Aguirre, E. Engel, G. Pavon, F.J. Gil, J.A. Planell, V. Migonney, C. Aparicio. Effect of blasting treatment and Fn coating on MG63 adhesion and differentiation on titanium: a gene expression study using real-time RT-PCR. Journal of Materials Science: Materials in Medicine (2011) 22:617-627.

C. Aparicio, D. Rodriguez, F.J. Gil. Variation of roughness and adhesion strength of deposited apatite layers on titanium dental implants. Materials Science and Engineering C: Materials for Biological Applications (2011) 31:320-324.

M. Pegueroles, C. Aparicio, M. Bosio, E. Engel, F.J. Gil, J.A. Planell, G. Altankov.Spatial Organization of Osteoblast Fibronectin-Matrix on Titanium Surface – Effects ofRoughness, Chemical Heterogeneity, and Surface Free Energy. Acta Biomaterialia (2010) 6, 291-301.

F.J. Gil, C. Aparicio, A. Padrós, J.M. Manero, J.A. Planell. Influence of the external hexagon and surface treatment on the fatigue resistance of titanium dental implants. International Journal of Oral and Maxillofacial Implants (2009) 24:583-590.

E. Engel, S. Del Valle, C. Aparicio, G. Altankov, L. Asin, J.A. Planell. M.P. Ginebra Topography mediated ion exchanged modulates osteoblast behaviour in bioactive materials. CPC as a model substrate. Tissue Engineering (2008) 14:1341-1351.

M. Pegueroles, J.A. Planell, F.J. Gil, C. Aparicio Effect of shot blasting and sterilization on the wettability and surface-energy properties of titanium surfaces. Surfaces and Coatings Technology. (2008) 202:3470-3479.

Northwestern University
T. Sargeant, C. Aparicio, J. Goldberger, H. Cui, S.I. Stupp. Mineralization of Peptide Amphiphiles Nanofibers and its Effect on Differentiation of Human Mesenchymal Stem Cells. Acta Biomaterialia (2012) 8(7):2456-2465.

S. Zhang, M. Greenfield, A. Mata, L. Palmer, R, Bitton, J.R. Mantei, C. Aparicio, M. Olvera, S.I. Stupp. A Self-Assembling Pathway to Aligned Monodomain Gels. Nature Materials (2010) 9:595-601.

A. Mata, Y. Biao, K. Henrikson, C. Aparicio, R. Satcher, S .Stock, S.I. Stupp. Bone regeneration mediated by biomimetic mineralization of a nanofiber matrix. Biomaterials (2010) 31:6004-6012.

A. Mata, L. Hsu, R. Capito, C. Aparicio, K. Henrikson, S.I. Stupp. Micro-patterning of Bioactive Self-Assembling Gels. (2009) Soft Matter 5:1228–1236.

BarcelonaTech-UPC
A. Michiardi, E. Engel, C. Aparicio, J.A. Planell, F.J. Gil. Oxidized NiTi surfaces enhance differentiation of osteoblast-like cells. (2008) Journal of Biomedical Materials Research Part A. 85A:108-114.

C. Aparicio, J.M. Manero, F. Conde, M. Pegueroles, J.A. Planell, M. Vallet-Regí, F.J. Gil. Acceleration of apatite nucleation on microrough bioactive titanium for bone-replacing implants. Journal of Biomedical Materials Research Part A (2007) 82A:521-529.

A. Michiardi, C. Aparicio, B. Ratner, J.A. Planell, F.J. Gil.The influence of surface energy on competitive protein adsorption on oxidized NiTi surfaces. Biomaterials (2007) 28: 586-594.

A. Michiardi, C. Aparicio, J.A. Planell, F.J. Gil Electrochemical behaviour of oxidized NiTi shape memory alloys. Surfaces and Coatings Technology (2007) 201:6484-6488.

F.J. Gil, J.A. Planell, A. Padrós, C. Aparicio. Effect of shot-blasting and heat treatment on fatigue fracture of titanium dental implants. Dental Materials (2007) 23: 486-491.

M. Arciniegas, C. Aparicio, J.M. Manero, F.J. Gil Low elastic modulus metals for joint prosthesis: Tantalum and nickel–titanium foams. European Ceramic Society Journal (2007) 27: 3391-3398.

P. Sevilla, C. Aparicio, J.A. Planell, F.J. Gil. Comparison of the mechanical properties between tantalum and nickel-titanium foams implant materials for bone ingrowth applications. Journal of Alloys and Compounds (2007) 439:67-73.

M. Barrabés, A. Michiardi, C. Aparicio, P. Sevilla, J.A. Planell, F.J. Gil. Oxidized nickel-titanium foams for bone reconstructions: chemical and mechanical characterization. Journal of Materials Science: Materials in Medicine (2007) 18:2123-2129.

A. Michiardi, C. Aparicio, J.A. Planell, F.J. Gil. New oxidation treatment of NiTi shape memory alloys to obtain Ni-free surfaces and improve biocompatibility. Journal of Biomedical Materials Research Part B: Applied Biomaterials (2006) 77B:249-256.

M. Navarro, C. Aparicio, M. Charles-Harris, M.P. Ginebra, E.Engel, J.A. Planell. Development of a biodegradable composite scaffold for bone tissue engineering: physico-chemical, topographical, mechanical, degradation and biological properties. Advances in Polymer Sciences (2006) 200:209-231.

T. Traykova, C. Aparicio, M.P. Ginebra, J.A. Planell. Nanoceramics as biomaterials. Nanomedicine-Future Medicine (2006) 1:91-106.

E. Engel, L. Asin, J.A. Delgado, C. Aparicio, J.A. Planell, M.P. Ginebra. Cell behaviour of Calcium Phosphate Bone Cement Modified with a Protein-based Foaming Agent. Key Engineering Materials (2005) 284-286:117-120.

L. Morejon, A.E. Mendizabal, J.A.D. Garcia-Menocal, M.P. Ginebra, C. Aparicio, F.J.G. Mur, M. Marsal, N. Davidenko, M.E. Ballesteros, J.A. Planell. Static mechanical properties of hydroxyapatite (HA) powder-filled acrylic bone cements: Effect of type of HA powder. Journal of Biomedical Materials Research Part B: Applied Biomaterials (2005) 72B:345-352.

M. Charles-Harris, M. Navarro, E. Engel, C. Aparicio, M. P. Ginebra and J. A. Planell Surface characterization of completely degradable composite scaffolds. Journal of Materials Science: Materials in Medicine (2005) 16:1125-1130.

C. Aparicio, F.J. Gil, U. Thams, F. Muñoz, A. Padrós, J.A. Planell. Osseointegration of grit-blasted and bioactive titanium implants: Histomorphometry in minipigs. Key Engineering Materials (2004) 254-256:737-740.

M.P. Ginebra, C. Aparicio, E. Engel, M. Navarro, F.J. Gil, J.A. Planell. Calcium phosphate bone substitutes. Medical Journal of Malaysia (2004) 59 (Suppl B): 65-6.

C. Aparicio, F.J. Gil, C. Fonseca, M. Barbosa, J.A. Planell. Corrosion Behaviour of Commercially Pure Titanium Shot Blasted with Different Materials and Sizes of Shot Particles for Dental Implant Applications. Biomaterials (2003) 24(2):263-273.

C. Aparicio, E. Engel, F.J. Gil, J.A. Planell. Human-osteoblast proliferation and differentiation on grit-blasted and bioactive titanium for dental applications. Journal of Materials Science Materials in Medicine (2002) 13:1105-1111.

F.J. Gil, A. Padrós, J.M. Manero, C. Aparicio, M. Nilsson, J.A. Planell. Growth of bioactive surfaces on titanium and its alloys for orthopaedic and dental implants. Materials Science and Engineering C: Materials for Biological Applications (2002) 22(1):53-60.

M.P. Ginebra, L. Albuixech, E. Fernández-Barragán, C. Aparicio, F.J. Gil, J. San Román, B. Vázquez, J.A. Planell. Mechanical performance of acrylic bone cements containing different radiopacifying agents. Biomaterials (2002) 23(8):1873-1882.

L.M. Rodríguez-Lorenzo, M. Vallet-Regí, J.M.F. Ferreira, M.P. Ginebra, C. Aparicio, J.A. Planell. Hydroxyapatite ceramic bodies with tailored mechanical properties for different applications. Journal of Biomedical Materials Research (2002) 60(1):159-166.

J.M. Manero, J. Salsench, J. Nogueras, C. Aparicio, A. Padrós, M. Balcells, F.J. Gil, J.A. Planell. Growth of Bioactive surfaces on dental implants. Implant Dentistry (2002) 11(2):170-175.

F.J. Gil, C. Aparicio, J.A. Planell. Effect of Oxygen Content on Grain Growth Kinetics and Mechanical Properties of Titanium. Journal of Materials Synthesis and Processing (2002) 10(5):263-266.

M.P. Ginebra, C. Aparicio, L. Albuixech, E. Fernández-Barragán, L. Morejón, F.J. Gil, B. Vázquez, J. San Román, J.A. Planell. Improvement of the mechanical properties of acrylic bone cements by substitution of the radiopaque agent. Journal of Materials Science: Materials in Medicine (1999) 10:733-737.

Book Chapters

X. Chen, Y. Li, C. Aparicio. Biofunctional Coatings for Dental Implants. In Thin Films and Coatings in Biology. Biological and Medical Physics -Biomedical Engineering Series; ed. S. Nazarpour. Springer-Verlag. ISBN 978-94-007-2592-8. pp 105-143.

C. Mas-Moruno, M. Espanol, E.B. Montufar, G. Mestres, C. Aparicio, F.J Gil, M.P. Ginebra. Bioactive metallic and ceramic surfaces for bone engineering. In Biomaterials Surface Science; eds. A. Taubert, J.F. Mano, J.C. Rodriguez-Cabello. Willey. ISBN 978-35-273-3031-7. pp 337-374.

C. Aparicio, Y. Maazouz, D. Yang. Measuring wettability of biosurfaces at the microscale. In Nanotechnology in Regenerative Medicine: Methods and Protocols. Methods in Molecular Biology Vol. 811; eds. M. Navarro, J.A. Planell (2012) Humana Press, Springer-Verlag. ISBN 978-1-61779-387-5. pp. 163-177.

G. Altankov, T. Groth, E. Engel, J. Gustavsson, M. Pegueroles, C. Aparicio, F.J. Gil, M.P. Ginebra, J.A. Planell. Development of Provisional Extracellular Matrix on Biomaterials Interface: Lessons from In Vitro Cell Culture. In Advances in Regenerative Medicine: Role of Nanotechnology, and Engineering Principles. NATO Science for Peace and Security Series A: Chemistry and Biology; eds. V.P. Shastri, G. Altankov, A. Lendlein (2010) ISBN 978-90-4818789-8, Springer Verlag, Dordrecht, The Netherlands. pp. 19-45.

J.A. Planell, M. Navarro, G. Altankov, C. Aparicio, E. Engel, J. Gil, M.P. Ginebra, D. Lacroix. Materials Surface Effects on Biological Interactions. In Advances in Regenerative Medicine: Role of Nanotechnology, and Engineering Principles. NATO Science for Peace and Security Series A: Chemistry and Biology; eds. V.P. Shastri, G. Altankov, A. Lendlein (2010) ISBN 978-90-4818789-8, Springer Verlag, Dordrecht, The

E. Fernández, F.J. Gil, C. Aparicio, M. Nilsson, S. Sarda, D. Rodríguez, M.P. Ginebra, J.M. Manero, M. Navarro, J. Casals, J.A. Planell. Materials in Dental Implantology. In Dental Biomechanics; ed. A. Natali (2003) Taylor and Francis, London. ISBN 0-41-5306663. pp 69-89.

M. Ontañón, C. Aparicio, M.P. Ginebra, J.A. Planell.Structure and Mechanical Properties of Bone. In Structural Biological Materials; ed. M. Elices (2000) Pergamon-Elsevier, New York. ISBN 0-08-0434169. pp. 31-72.

 

Links

Minnesota Dental Research Center for Biomaterials and Biomechanics

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