Darryl Hamamoto

Darryl Hamamoto

Academic Title

Associate Dean of Advanced and Graduate Education
Associate Professor
Division of Oral Medicine
Department of Diagnostic and Biological Sciences


General Practice Residency, Certificate, University of North Carolina, 1989 - Oral Medicine Residency, Certificate, University of Washington, 1993
Clinical Cancer and Infectious Diseases Fellowship, Certificate, University of North Carolina, 1990
Microbiology, BA, University of California, Los Angeles, 1983
Oral Biology, Ph.D., University of Minnesota, 2000
Other Education
Dentistry, Doctor of Dental Surgery (DDS), University of California, Los Angeles, 1987

Contact Info




Office Address

7-536 Moos Tower
515 Delaware St. SE
Minneapolis, MN 55455

Bio Statement

Dr. Hamamoto is an Associate Professor in the Division of Oral Medicine, Oral Diagnosis, and Oral and Maxillofacial Radiology, Department of Diagnostic and Surgical Sciences, School of Dentistry, University of Minnesota. He is a member of the Oral Biology Graduate Faculty and the School of Dentistry Graduate Faculty. Dr. Hamamoto has mentored high school, undergraduate, dental, and graduate students in both clinical and basic science research.

Dr. Hamamoto is the Assistant Dean for Academic Affairs and participated in the development of the first dental therapy program in the U.S based in a dental school.

Dr. Hamamoto has authored/co-authored publications in the areas of the acid-evoked pain, cancer-evoked pain, antihyperalgesic effects of cannabinoid derivatives, and glycemic control in diabetic dental patients. Dr. Hamamoto serves as an ad hoc reviewer for national and international basic science and dental journals.

Dr. Hamamoto has been awarded two University of Minnesota Graduate School Grants-in-Aid of Research, a National Institutes of Health R03 grant, and is or has been a Co-investigator or Investigator on five other National Institutes of Health grants.

Dr. Hamamoto has been a Fellow in the Bush Early Career Faculty Program at the University of Minnesota. He was elected to the national dental honor society, Omicron Kappa Upsilon, in 1987 and the national honor society, Phi Beta Kappa, in 1983.

Research Interests


Physical Evaluation of Dental Patients

Management of Medically Compromised Dental Patients

Neuroscience for Dental Students

Interprofessional Education


Antihyperalgesic Effects of Cannabinoids

Tumor-evoked Cancer Pain

Electrophysiological responses of spinal neurons and primary afferent fibers to nociceptive stimuli

Animal Models of Muscle Pain

Myofascial Pain of the Masticatory Muscles

Research Projects

Cannabinoid Modulation of Hyperalgesia, 20% effort, Co-investigator, NIH/NIDA
$975,000 March 2005 - December 2009

Neural Mechanisms of Cancer Pain, 15% effort, Co-investigator, NIH/NIDA
$815,000 September 2007 – July 2012


Bush Early Career Faculty Fellow, University of Minnesota 2001-2002

Dentist Scientist Award, University of Minnesota 1992-1998

Salivary Gland Research Training Fellow, University of Washington 1990-1991

Fellow, American Association of Hospital Dentistry 1989-1994

Doctor of Dental Surgery, Graduation with honors 1987

Omicron Kappa Upsilon, Epsilon Zeta Chapter, Dental Honor Society 1987

Outstanding Senior Achievement Award, Southern California Japanese American Dental Society 1987

Southern California Academy of General Dentistry Award 1987

UCLA School of Dentistry Section of Removable Prosthodontics Award 1987

UCLA Dental Auxiliary Utilization Award 1987

Jake Gimbel Scholarship 1986\

Hortense Fishbaugh Memorial Scholarship 1986

UCLA School of Dentistry Dean's Recognition 1984-1985

Phi Beta Kappa, Eta Chapter 1983

UCLA School of Dentistry Regents Scholarship 1983

UCLA Rehabilitation Services Guild Scholarship 1983

Bachelor of Arts, Microbiology, Summa cum Laude 1983

UCLA Dean's Honor List 1978-1983

Byron Holland Scholarship 1978


Publications in Refereed Journals

Hamamoto, D.T. and Luderitz, J.R. Intramuscular pH in myofascial pain of the masticatory muscles. Journal of Musculoskeletal Pain, 2009;17:224-238.

Hamamoto, D.T. and Rhodus, N.L. Methamphetamine abuse and dentistry, Oral Diseases, 2009;15:27-37.

Simone, D.A. Khasabov, S.G., and Hamamoto, D.T. Changes in response properties of nociceptive dorsal horn neurons in a murine model of cancer pain. Acta Physiologica Sinica 2008;60:635-644.

*Hamamoto, D.T., *Khasabov, S., Cain D.M., and Simone, D.A. Tumor-evoked sensitization of C nociceptors: A Role for Endothelin. Journal of Neurophysiology 2008;100:2300-2311. *Contributed equally

Khasabov, S.G., Hamamoto, D.T., Harding-Rose, C., and Simone, D.A. Tumor-evoked Hyperalgesia and Sensitization of Nociceptive Dorsal Horn Neurons in a Murine Model of Cancer Pain. Brain Research 2007;1180:7-19.

Hsu, K.T., Shuman, S.K., Hamamoto, D.T., Hodges, J.S., and Feldt, K.S. The application of facial expressions to assess orofacial pain in cognitively impaired older adults. Journal of the American Dental Association 2007;138:963-969.

Hamamoto, D.T., Giridharagopalan, S., and Simone, D.A. Acute and chronic administration of the cannabinoid receptor agonist CP 55,940 attenuates tumor-evoked hyperalgesia. European Journal of Pharmacology 2007;558:73-87.

Rhodus NL, Vibeto BM, and Hamamoto DT. Glycemic control in patients with diabetes mellitus upon admission to a dental clinic: considerations for dental management. Quintessence International, 2005;36:474-482.

Hamamoto DT and Simone DA. Characterization of cutaneous primary afferent fibers that are excited by acetic acid in a model of nociception in frogs. Journal of Neurophysiology 2003;90:566-577.

*Kehl LJ, *Hamamoto DT, Wacnik PW, Croft DL, Norsted BDA, Wilcox GL, and Simone DA. A Cannabinoid agonist differentially attenuates deep tissue hyperalgesia in animal models of cancer and inflammatory muscle pain. Pain 2003;103(1-2):175-186. *Contributed equally

Turner MS, Hamamoto DT, Hodges JS, Maccecchini ML and Simone DA. SYM 2081, An agonist that desensitizes kainate eeceptors, attenuates capsaicin and inflammatory hyperalgesia. Brain Research 2003;973:252-264.

Hamamoto DT, Forkey MW, Davis WL, Kajander KC, and Simone DA. The role of pH and osmolarity in evoking the acetic acid-induced wiping response in a model of nociception in frogs. Brain Research 2000;862(1-2):217-229.

Hamamoto DT, Ortiz-Gonzalez XR, Honda JM, and Kajander KC. Intraplantar injection of hyaluronic acid at low pH into the rat hindpaw produces tissue acidosis and enhances withdrawal responses to mechanical stimuli. Pain 1998;74:225-234.

Publications in Books

Hamamoto, D.T. and Simone, D.A. Cancer and Chemotherapy-induced Neuropathic Pain in Mechanisms of Pain in Peripheral Neuropathy, Editors Zhang, JM and Dobretsov, M, Transworld Research Network, Kerala, India (in press).

Hamamoto DT and Simone DA. Muscle Pain: Inflammation-induced. In: Encyclopedic Reference of Pain, Editors Schmidt, R.F. and Willis, W.D. Springer-Verlag, Heidelberg, Germany 2006.

Hamamoto DT and Simone DA. Animal Models of Bone Cancer Pain. In: Encyclopedic Reference of Pain, Editors Schmidt, R.F. and Willis, W.D. Springer-Verlag, Heidelberg, Germany 2006.

Hamamoto DT. Myasthenia Gravis. In: Dental Clinical Advisor, Editors J. Hupp, T. Williams, and F. Firriolo. Elsevier/Mosby 2006.

Hamamoto DT. Polymyositis. In: Dental Clinical Advisor, Editors J. Hupp, T. Williams, and F. Firriolo. Elsevier/Mosby 2006.

Hamamoto DT. Muscular Dystrophy. In: Dental Clinical Advisor, Editors J. Hupp, T. Williams, and F. Firriolo. Elsevier/Mosby 2006.

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  • Last modified on July 30, 2012