David A. Bereiter

David A. Bereiter

David A. Bereiter, Ph.D.

Academic Title

Division of Basic Sciences
Department of Diagnostic and Biological Sciences


Physiology, BS, University of Illinois, 1969
Physiology, Ph.D., University of Illinois, 1976
Other Education
Neuroendocrinology, Post-doctoral, University of Geneva, 1976-1980

Contact Info




Office Address

18-241 Moos Tower
515 Delaware St. SE
Minneapolis, MN 55455

Bio Statement

Dr. Bereiter received his doctorate degree from the University of Illinois, Champaign-Urbana, in physiology with specialization in neurophysiology and postdoctoral training in neuroendocrinology at the University of Geneva, Switzerland with Professor Jeanrenaud. He joined Brown Medical School faculty as an Assistant Professor in 1983 and was promoted to full Professor in Surgery and Neuroscience in 1995.

The research interests of his laboratory focus on peripheral and central mechanisms of craniofacial pain with particular emphasis on ocular pain and pain referred to the temporomandibular joint region. Since many craniofacial pain conditions are more prevalent in women than men, additional interests include the roles of sex hormones and psychophysical stress on craniofacial pain. Current research effort is supported by extramural funds from the National Institute for Dental and Craniofacial Research and the National Eye Institute.

Research Interests

Central nervous system mechanisms of craniofacial pain
Influence of sex hormones on pain sensation
Trigeminal nerve physiology and anatomy


Bereiter, D.A. and D.J. Barker. Hormone-Induced Enlargement of Receptive Fields in Trigeminal Mechanoreceptive Neurons. I. Time Course, Hormone and Sex Specificity. Brain Res. 184: 395-410, 1980.

Bereiter, D.A., L.R. Stanford, and D.J Barker. Hormone-induced Enlargement of Receptive Fields in Trigeminal Mechanoreceptive Neurons. II. Possible Mechanisms. Brain Res. 184: 411-423, 1980.

Bereiter, D.A., A.P. Benetti and K.V. Thrivikraman. Thermal nociception potentiates the release of ACTH and norepinephrine by blood loss. Am. J. Physiol. 259: R1236-1242, 1990.

Hathaway, C.B., J.W. Hu and D.A. Bereiter. Distribution of Fos-like immunoreactivity in the caudal brain stem of the rat following noxious chemical stimulation of the temporomandibular joint. J. Comp. Neurol. 356: 444-456, 1995.

Meng, I.D., J.W. Hu, A.P. Benetti and D.A. Bereiter. Encoding of corneal input in two distinct regions of the spinal trigeminal nucleus in the rat: cutaneous receptive field properties, responses to thermal and chemical stimulation, modulation by diffuse noxious inhibitory controls, and projections to the parabrachial area. J. Neurophysiol. 77: 43-56, 1997.

Hirata, H., Okamoto, K., Tashiro, A., and Bereiter, D. A. A novel class of neurons at the trigeminal subnucleus interpolaris/caudalis transition region monitors ocular surface fluid status and modulates tear production. J. Neurosci. 24: 4224-4232, 2004.

Bereiter, D.A., J.L. Cioffi, D.F. Bereiter, G. Zardeneta and S.B. Milam. Local blockade of integrins in the temporomandibular joint region reduces Fos-positive neurons in trigeminal subnucleus caudalis of female rats produced by jaw movement. Pain 125: 65-73, 2006.

Bereiter, D.A., and A.P. Benetti. Amino acid release at the spinomedullary junction after inflammation of the TMJ region in male and female rats. Pain 2006;126:175-183.

Tashiro A, Okamoto K, Milam SB, and Bereiter DA. Differential effects of estradiol on encoding properties of TMJ units in laminae I and V at the spinomedullary junction in female rats. J Neurophysiol 98: 3242-3253, 2007.

Okamoto K, Bereiter DF, Thompson R, Tashiro A, Bereiter DA. Estradiol replacement modifies c-fos expression at the spinomedullary junction evoked by temporomandibular joint stimulation in ovariectomized female rats. Neuroscience, 156: 729-736, 2008.

Tashiro, A., K. Okamoto and D.A. Bereiter. Morphine modulation of TMJ units in superficial laminae at the spinomedullary junction in female rats depends on estrogen status. Eur J Neurosci, 28: 2065-2074, 2008.

Okamoto K, Bereiter DF, Tashiro A, and Bereiter DA. Ocular surface-evoked Fos-like immunoreactivity is enhanced in trigeminal subnucleus caudalis by exposure to endotoxin. Neuroscience 159: 787-794, 2009.

Okamoto K, Thompson R, Tashiro A, Chang, Z and Bereiter DA. Bright light produces Fos-positive neurons in caudal trigeminal brainstem. Neuroscience 160: 858-864, 2009.

Nixdorf DR, John MT, Schierz O, Bereiter DA, and Hellekant G. Self-reported severity of taste disturbances correlates with dysfunctional grade of TMD pain. J Oral Rehabil 36: 792-800, 2009.

Bereiter, D.A. K. M. Hargreaves and J.W. Hu. Trigeminal mechanisms of nociception: peripheral and brain stem organization. In: Handbook of the Senses, vol. 5, Science of Pain, M.C. Bushnell and A.I. Basbaum (Eds), Elsevier, San Diego, 2009, pp. 435-460.

Okamoto K, Tashiro A, Chang, Z and Bereiter DA. Bright light activates a trigeminal nociceptive pathway. Pain 149: 235-242, 2010.

Tashiro A, Okamoto K, Chang Z, Thompson R and Bereiter DA. Behavioral and neurophysiological correlates of nociception in an animal model of photokeratitis. Neuroscience 169: 455-462, 2010.

Chang Z, Okamoto K, Tashiro A and Bereiter DA. UV irradiation of the eye and Fos-positive neurons induced in trigeminal brainstem after intravitreal or ocular surface TRPV1 activation. Neuroscience 170: 678-685, 2010.

Moana-Filho EJ, Nixdorf DR, Bereiter DA, John MT, Harel N. Evaluation of a magnetic resonance-compatible dentoalveolar tactile stimulus device. BMC Neurosci 11:142, 2010.

Duenes SL, Thompson R, Chang Z, Okamoto K, Bereiter DA. Psychophysical stress increases the expression of phospho-CREB, Fos protein and neurokinin-1 receptors in superficial laminae of trigeminal subnucleus caudalis in female rats. Neuroscience Lett 486: 207-210, 2010.

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