James Hinrichs

James Hinrichs

Academic Title

Professor and Director
Advanced Education Program in Periodontology
Division of Periodontology
Department of Developmental and Surgical Sciences


BS, University of Nebraska, 1973
Periodontology, MS, University of Nebraska, 1979
Dentistry, Doctor of Dental Surgery (DDS), University of Nebraska, 1975

Contact Info




Office Address

7-368 Moos Tower
515 Delaware St. SE
Minneapolis, MN 55455

Bio Statement

Dr. Hinrichs co-authored 21 articles in referred journals and one chapter in a periodontal textbook. He participated in 16 funded research projects while serving as Principal Investigator for 6 of these projects. The research focus has involved clinical diagnostic parameters for periodontal disease including analysis of microbiology, gingival crevicular fluid, subgingival blood flow and more recently periodontal bone regeneration via recombinant human platelet-derived grown factor-BB. He's had the privilege of participating in the 1989, 1996 and 2003 World Workshop in Periodontics as sponsored by the American Academy of Periodontology to author consensus papers on the current state of Periodontics as well as where the field will go in the next decade. As a member of the American Academy of Periodontology's Research Science and Therapy Committee, he co-authored 8 position papers to help set the standards for the profession. He has co-authored 24 abstracts on research projects and has served as a reviewer for the International Journal of Periodontics and Restorative Dentistry as well the Journal of the American Dental Association.

Research Interests

Periodontal regeneration as well as bacterial and genetic risk factors association with periodontitis.

Extracrevicular Invasion by Periodontal Pathogens. NIH/NIDCR R01-DE1214-01, 07/01/01-06/30/06. Total direct costs $1,000,000. PI: Joel Rudney (10% effort clinical investigator).

Double-Blind, Controlled, Parallel-Arm, Pivotal Human Clinical Trial to Evaluate the Safety and Effectiveness of TCP Plus for the Treatment of Periodontal Bone Defects, 05/01/02-07/01/05. BioMimetic Pharmaceuticals. Amount awarded $95,000. Principal Investigator: James E. Hinrichs (20% effot in 2002, 10% effort in 2003-2005).


1. Seong WJ, Conrad HJ and Hinrichs, JE: Potential damage to the bone-implant interface by an implant stability measuring initial implant stability. J Periodontol 80:1868-1874, 2009.

2. Johnson J, Chen R, Lenton P, Zhang G, Hinrichs J and Rudney J: Persistence of extracrevicular bacterial Reservoirs after treatment of aggressive periodontitis. J Periodontol 79:2305-2312, 2008.

3. Wohlfahrt, JC, Wu T, Hodges J, Hinrichs J, and Michalowicz M. No association between selected candidate gene polymorphisms and severe chronic periodontitis. J Periodontol. 77:426-436, 2006.

4. Nevins, M, Giannobile, W., McGuire, M., Kao, R., Mellonig, J., Hinrichs, J., McAllister, B., Murphy, K., McClain, P., Nevins, M., Paquette, D., Han, T., Reddy, M., Lavin, P., Genco, R., and Lynch, S. Platelet-derived growth factor stimulates bone fill and rate of attachment level gain: results of a large multicenter randomized controlled trial. J Periodontol. 76:2205-2215, 2005.

5. Klepp M, Schaffer EM, Hinrichs JE, Eastlund T. Histologic evaluation of demineralized freeze-dried bone allografts in barrier membrane covered periodontal fenestration wounds and ectopic sites in dogs. J Clin Periodontol. 31: 534-544, 2004.

6. Michalowicz, B., Wolff, L., Klump, D., Hinrichs, J., Aeppli, D., Bouchard, T. and Pihlstrom, B. Periodontal bacteria in adult twins. J Periodontol 70: 263-273, 1999.

7. Wolff, L., Kim, A., Nunn, M., Bakdash, B. and Hinrichs, J. Effectiveness of a sonic toothbrush in maintenance of dental implants. A prospective study. J Clin Periodontol. 25: 821-828, 1998

8. O'Brien, T., Roszkowski, M., Wolff, L., Hinrichs, J., and Hargraves, K Effect of a non-steroidal anti-inflammatory drug on tissue levels of iPGE2, iLTB4 and pain after periodontal surgery. J Periodontol 67: 1307-1316, 1996.

9. Liljemark, W., Bloomquist, C., Bandt, C., Pihlstrom, B., Hinrichs, J. and Wolff, L. Comparison of the distribution of Actinomyces in dental plaques on inserted enamel and natural tooth surfaces in periodontal health and disease. Oral Microbiol. Immunol. 8:5-15, 1993.

10. Michalowicz, B., Aeppli, D., Virag, J., Klump, D., Hinrichs, J., Segal, N., Bouchard, T. and Pihlstrom, B. Periodontal findings in adult twins. J. Periodontol. 62:293-299, 1991.

11. Smith Q., Hinrichs J. and Hamilton, M. Phenytoin and 5-(p-hydroxyphenyl)-5-phenylhydantoin do not alter the effects of bacterial and amplified plaque extracts on cultures of fibroblasts from normal and overgrown gingivae. J Dent Res. 66:1393-1398, 1987.

12. Hinrichs, J. Hospital Periodontics: A survey of hospital utilization by American Academy of Periodontology members. J. Periodontol. 57:633-671, 1986.

13. ElDeeb, M., Hinrichs, J., Waite. D., Bandt, C. and Bevis, R. Repair of alveolar cleft defects with autogenous bone grafting; periodontal evaluation. J. Cleft Palate 23:126-136, 1986.

14. Smith, Q., Hinrichs, J. and Melnyk, R. Gingival crevicular fluid myeloperoxidase at periodontitis sites. J. Periodont. Res. 21:45-55, 1986.

15. Walker, J., Hinrichs, J. and Dyer, J. Phagocytosis of Actinomyces viscosus by murine macrophages. Susceptible and resistant strains. J. Periodont. Res. 20:564-570, 1985.

16. Hinrichs, J., Wolff, L., Pihlstrom, B., Schaffer, E., Liljemark, W. and Bandt, C. Effects of scaling and root planing on subgingival microbial proportions standardized in terms of their naturally occurring distribution. J. Periodontol. 56:187-194, 1985.

17. Hinrichs, J., ElDeeb, M., Waite, D., Bevis, R. and Bandt, C A periodontal evaluation of canines erupted through grafted alveolar cleft defects. J. Oral Maxillofac. Surg. 42:717-721, 1984.

18. Hinrichs, J., Bandt, C., Smith, J. and Golub, L A comparison of three systems for quantitating gingival crevicular fluid with respect to linearity and the effects of qualitative differences in fluids. J. Clin. Periodontol. 11:652-661, 1984.

19. Hinrichs, J., Bandt, C. and Smith, J. Relative error (variability) associated with an improved instrument for measuring gingival crevicular fluid. J. Periodontol. 55:294-298, 1984.

20. Bandt, C., Liljemark, W., Pihlstrom, B., Hinrichs, J., Schaffer, E., Wolff, L. The use of selective media for examining the relationship between dental plaque microorganisms and periodontal disease in a large sample clinical investigation. J. Periodont. Res. 17:518-520, 1982.

21. Kalkwarf, K., Hinrichs, J. and Shaw, D. Management of the dental patient receiving corticosteroid medication. Oral Surgery, Oral Medicine, Oral Pathology 54:396-400, 1982


1. Clinical Periodontology by Carranza, F., Newman, M. and Takei, H. Chapter 4, entitled, “Classification of Diseases and Conditions Affecting the Periodontium” by, James E Hinrichs.and M John Novak 11th edition by W. B. Saunders, St. Louis, Missouri, Submitted in August ‘09 and under final revision by the editor.

2. Clinical Periodontology by Carranza, F., Newman, M. and Takei, H. Chapter 22, _ entitled, “The Role of Dental Calculus and Other Predisposing Factors” by James E Hinrichs. 11thedition by W. B. Saunders, St. Louis, Missouri, Submitted in August ‘09 and under final revision by the editor.

3. Veterinary Dentistry by Brook A Niemiec Chapter ___, pages ___-___ entitled, “The Structure and Function of the Periodontium” by Kevin S. Stepaniuk and James E. Hinrichs Submitted to editor May ’10 and under final revision by the editor.

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