Department of Diagnostic and Biological Sciences
Microbiology, Bsc(H), University of Otago (New Zealand), 1987
Microbiology, Ph.D., University of Otago (New Zealand), 1992
Molecular Biology, Post doctorate, University of Minnesota, 1992-1996
17-164 Moos Tower
515 Delaware St. SE
Minneapolis, MN 55455
Testing the hypothesis that Calprotectin serves as an innate intraepithelial defense against bacterial invasion in vitro and provide evidence for a fundamental role for this protein in resistance to infections. Such knowledge may lead to novel prevention and therapeutic approaches to improve innate defense against pathogens.
R21 DE015056-01 (Ross)
HIV Modulates Oral Mucosal Calprotectin and Candidiasis
Goal: To determine if HIV infection of oral mucosal epithelial cells will down-regulate calprtoectin causing reduced resistance to Candidal infections.
RO1 DE11831-01-09 (Herzberg)
Innate Intraepithelial Defense Against Oral Infection
Goal: To determine the intracellular trafficking and structural basis for antimicrobial function of the epithelial protein complex, Calprotectin (S100A8/A9).
R01 DE015503-01 (Herzberg)
Oral Epithelial Cells: Innate Immune "Gatekeeper" of HIV
Goal: To identify and profile oral keratinocyte innate immune gene expression in response to HIV and P. gingivalis proteases.
Basi, D.L., Ross, K.F., Hodges, J.S., & Herzberg, M.C. The modulation of tissue factor by endothelial cells during heat shock. J. Biol. Chem. 278: 11065-11071, 2003. http://www.jbc.org/cgi/content/full/278/13/11065
Nisapakultorn K, Ross K F and Herzberg M C (2001). Calprotectin expression in vitro by oral epithelial cells confers resistance to infection by Porphyromonas gingivalis. Infect Immun 69:4242-4247 http://iai.asm.org/cgi/content/full/69/7/4242?view=long&pmid=11401960
Nisapakultorn K, Ross K F and Herzberg M C (2001). Calprotectin expression inhibits bacterial binding to mucosal epithelial cells. Infect Immun 69: 3692-3696 http://iai.asm.org/cgi/content/full/69/6/3692?view=long&pmid=11349032
Ross K F and Herzberg MC (2001). Calprotectin expression by gingival epithelial cells. Infect Immun 69: 3248-3254 http://iai.asm.org/cgi/content/full/69/5/3248?view=long&pmid=11292747
Ross K F, C W Ronson and J R Tagg (1993). Isolation and characterization of the lantibiotic salivaricin A and its structural gene sal A from Streptococcus salivarius 20P3. Appl Environ Microbiol. 59: 2014-2021 http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=8357242