Karen Ross

Karen Ross

Academic Title

Research Associate
Department of Diagnostic and Biological Sciences

Education

Bachelor's
Microbiology, Bsc(H), University of Otago (New Zealand), 1987
Ph.D.
Microbiology, Ph.D., University of Otago (New Zealand), 1992
Other Education
Molecular Biology, Post doctorate, University of Minnesota, 1992-1996

Contact Info

Email
rossx007@umn.edu

Phone
612-626-1932

Fax
612-626-2651

Office Address

17-164 Moos Tower
515 Delaware St. SE
Minneapolis, MN 55455

Research Interests

Testing the hypothesis that Calprotectin serves as an innate intraepithelial defense against bacterial invasion in vitro and provide evidence for a fundamental role for this protein in resistance to infections. Such knowledge may lead to novel prevention and therapeutic approaches to improve innate defense against pathogens.

Research Projects

NIH/NIDCR
R21 DE015056-01 (Ross)
HIV Modulates Oral Mucosal Calprotectin and Candidiasis
Goal: To determine if HIV infection of oral mucosal epithelial cells will down-regulate calprtoectin causing reduced resistance to Candidal infections.

RO1 DE11831-01-09 (Herzberg)
Innate Intraepithelial Defense Against Oral Infection
Goal: To determine the intracellular trafficking and structural basis for antimicrobial function of the epithelial protein complex, Calprotectin (S100A8/A9).

R01 DE015503-01 (Herzberg)
Oral Epithelial Cells: Innate Immune "Gatekeeper" of HIV
Goal: To identify and profile oral keratinocyte innate immune gene expression in response to HIV and P. gingivalis proteases.

Publications

Basi, D.L., Ross, K.F., Hodges, J.S., & Herzberg, M.C. The modulation of tissue factor by endothelial cells during heat shock. J. Biol. Chem. 278: 11065-11071, 2003. http://www.jbc.org/cgi/content/full/278/13/11065

Nisapakultorn K, Ross K F and Herzberg M C (2001). Calprotectin expression in vitro by oral epithelial cells confers resistance to infection by Porphyromonas gingivalis. Infect Immun 69:4242-4247 http://iai.asm.org/cgi/content/full/69/7/4242?view=long&pmid=11401960

Nisapakultorn K, Ross K F and Herzberg M C (2001). Calprotectin expression inhibits bacterial binding to mucosal epithelial cells. Infect Immun 69: 3692-3696 http://iai.asm.org/cgi/content/full/69/6/3692?view=long&pmid=11349032

Ross K F and Herzberg MC (2001). Calprotectin expression by gingival epithelial cells. Infect Immun 69: 3248-3254 http://iai.asm.org/cgi/content/full/69/5/3248?view=long&pmid=11292747

Ross K F, C W Ronson and J R Tagg (1993). Isolation and characterization of the lantibiotic salivaricin A and its structural gene sal A from Streptococcus salivarius 20P3. Appl Environ Microbiol. 59: 2014-2021 http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=8357242

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  • Last modified on May 14, 2012