Mark Herzberg

Mark Herzberg

Academic Title

Professor
MinnCResT Program, Director
Mucosal and Vaccine Research Center
Division of Basic Sciences
Department of Diagnostic and Biological Sciences

Education

Bachelor's
Literature, BA, State University College (Oneonta, NY), 1967
Master's
English Education, MS, City College of New York Graduate School of Education, 1969
Ph.D.
Ph.D, State University of New York at Buffalo Graduate School Department of Oral Biology, 1978
Other Education
Dentistry, Doctor of Dental Surgery (DDS), New York University, The Brookdale Dental Center, 1973 - Specialty certificate, State University of New York at Buffalo, 1978

Contact Info

Email
mcherzb@umn.edu

Phone
612-625-8404

Fax
612-626-2651

Office Address

17-164 Moos Tower
515 Delaware St. SE
Minneapolis, MN 55455

Bio Statement

Professional Experience:

Professor, Department of Oral Sciences, School of Dentistry, University of Minnesota, Minneapolis (6/02-present)

Member, National Advisory Dental Research Council, NIDCR (9/03-present)

Director, Minnesota Craniofacial Research Training Program (NIH/NIDCR T32DE07288-07-11; 8/02-present)

Editor Emeritus, Journal of Dental Research (3/04-present)

Editor, Journal of Dental Research (4/93-3/04)

Member, Boards of Directors and Joint Finance Committee of the International and American Associations of Dental Research (4/93-3/04)

William Evans Visiting Fellow, University of Otago, Dunedin NZ (1994)

Professor, Department of Preventive Science, School of Dentistry, University of Minnesota, Minneapolis (7/90 ­ 6/02)

Postgraduate Visiting Fellow, Department of Experimental Oral Biology, University of Otago, Dunedin, NZ (1991)

Director, University of Minnesota Dentist-Scientist Award Training Program (NIH-supported; 4/89-6/03)

Associate Professor, Department of Preventive Science, School of Dentistry, University of Minnesota, Minneapolis (9/88 - 6/90)

Associate Professor of Periodontology and Oral Biology, School of Dentistry, University of Minnesota, Minneapolis (7/1/83 - 9/88)

Visiting Professor, Department of Biophysics, Weizmann Institute of Science, Rehovot, Israel, (3/84 - 6/84)

Assistant Professor of Periodontology and Oral Biology, School of Dentistry, University of Minnesota, Minneapolis (7/1/78 - 6/30/83)

Graduate Faculty: Dentistry (elected 12/4/78) Oral Biology (10/30/78) Cell, Molecular, Developmental Biology, and Genetics (3/4/81)

Attending Staff, University of Minnesota Hospitals and Clinics (10/28/87-9/1/97)

Consulting periodontist, Boynton Health Service, University of Minnesota (1991-2003; MN dental practice license no. 8689)

Leadership Roles

Scholarly Journals
Advisory Board, Archives of Oral Biology 1988 - 1993
Editorial Board, Journal of Periodontology 1988 - present
Reviewer:
J. Clin. Microbiol., 1983 - present
Arch. Oral Biol. 1984 - present
J. Dent. Res. 1984 - present
J. Biomechanical Engineering 1985 - present
Infect. Immun. 1987 - present
J. Lab. Clin. Med. 1987 - present
J. Periodontol 1988 - present
Canadian J. Microbiol. 1988 - present
Molecular Microbiol. 1992 - present
Thrombosis & Haemostasis 1995 - present

Activity in Professional Societies

International and American Associations for Dental Research
Nominating Committee 1987-present
Chairperson 1990-1991

Microbiology and Immunology Research Group
President elect 1990-1991
President 1991-1992
Past President 1992-1993
Editor, Journal of Dental Research 1993-2004
Member, Board of Directors 1993-2004

American Heart Association
Council on Thrombosis 1985-1994
Council on Cardiovascular Disease in the Young  1985-1994

American Association for the Advancement of Science 1973-present
Delegate to the Council of AAAS, Division of Dentistry 1990-1993
Electorate Nominating Committee, Division of Dentistry 1998-2001

European Research Group for Oral Biology, planning committee for the 30th annual conference: 1997-present
'Oral Biology at the Turn of the Century', Interlachen, Switzerland, August 20 - 23, 1998;
also invited to write summary paper for symposium on emerging frontiers in the new century. 1997 - present

National Institute for Dental and Craniofacial Research 1999-present
American Academy for Periodontology Joint Symposium Planning Committee:
Periodontal Diseases and Systemic Diseases, April 17-19, 2001 1999-present

School of Dentistry

Research Committee 1978 - 1983, 1988 - present
Committee for the Selection of Committees 1980 - 1986
Chair 1982 - 1986

Postdoctoral Program in Cariology: Steering Committee 1981 - 1987

Space Management Committee 1981 - 1984

Lasby Visiting Professorship Committee 1982-1983, 1986-1996
Chair 1996

Continuing Education Advisory Committee 1982 - 1983

Clinical Affairs Committee, Infection and Disease Control Subcommittee 1985 - 1987

Organizing Committee 1986
National Dental Student Research Conference (NIH-sponsored)
April 6-8, 1986. University of Minnesota.

Strategic Planning Committee 1986 - 1987 and 1997

Ad hoc Dental Research Institute Founding Committee 1986 - 1987

Strategic Planning Committee 1986-1987
Co-author of "A Strategic Plan: A Faculty's Proactive Commitment to Change and Excellence"
Presented to President of University of Minnesota, July 15, 1987. 1986 - 1987

Pew Foundation National Dental Education Program Planning Committee
Co-author of Phase II proposal; August 26, 1987 ($1 million). 1987

Intramural Practice ad hoc Committee 1987-1991

Immunologist Faculty Search Committee, Chair 1988

Executive Committee, Dental Research Institute 1989 - 2002

Promotion, Tenure and Appointment Committee 1992 - 2002

Strategic Planning Committee
Co-author of "A Strategic Plan for the School of Dentistry: 1997-1999."
Presented to the Senior Vice President for Health Sciences, Dr. Frank Cerra. 1997

Promotion, Tenure and Appointment Committee, Chair 1998 - 2002

Dean Search Committee, School of Dentistry 1998 - 2000

University of Minnesota

Committee on the Use of Human Subjects in Research 1981 - 1987

University Faculty Senate 1981 - 1987

All University Radiation Safety Committee 1991 - 1994

Awards

New York State Regents' College Scholarship 1963 - 1967

The State University College of Oneonta, Alumni Scholarship 1966 - 1967

Master's Fellowship in Urban Education, City College of New York 1967 - 1969

U.S. Public Health Service Summer Research Fellowship 1970

NIDR Postdoctoral Traineeship 1973 - 1978\

Sigma Xi (elected to full membership) 1/82

Omicron Kappa Upsilon (elected to full membership) 4/83

NIH/Oral Biology Study Section (ad hoc reviewer) 1983 - present

NIH/Physiology Study Section (ad hoc panel) 1985

NIH/Oral Biology Study Section (special member) 1985 - 1990

NIH/Oral Biology Study Section-2 (regular member) 1991-1995

American Cancer Society Institutional Grant Review Committee member 1985 - present

Veterans Administration/Oral Biology Study Section (member) 1986

Scientific Review Board, University of Rochester Cariology Center 1987 - 2002

Advisory Board, Archives of Oral Biology 1988 - 1994

Editorial Board, Journal of Periodontology 1988 - 1993

Fellow, American Association for the Advancement of Science (elected) 1992

Clinical Research Award in Periodontology, American Academy of Periodontology 1993

William Evans Fellow of the University of Otago, Dunedin NZ 6-8/94

IADR Distinguished Scientist Award in Oral Biology 1995

Publications

Levine, M.J., M.C. Herzberg, M.S. Levine, S.A. Ellison, N.W. Stinson, H.C. Li and T. Van Dyke. Specificity of salivary-bacterial interactions: Role of terminal sialic acid residues in the interaction of salivary glycoproteins with Streptococcus sanguis and Streptococcus mutans. Infect. Immun. 19:107-115, 1978.

Levine, M.J., M.C. Herzberg, S.A. Ellison, J.P. Shomers and G.A. Sadowski. Biochemical and immunological comparison of monkey and human salivary secretions. Compar. Biochem. Physiol. 60B:423-431, 1978.

Herzberg, M.C., M.J. Levine, S.A Ellison and L.A. Tabak. Purification and characterization of monkey salivary mucin. J. Biol. Chem. 254:1487-1494, 1979.

Van Dyke, T.E., M.J. Levine, M.C. Herzberg, S.A. Ellison and D.I. Hay. The isolation from monkey extra-parotid saliva of a low molecular weight glycoprotein inhibitor of calcium-phosphate precipitation. Arch. Oral. Biol. 24:85-90, 1979.

Clawson, C.C., J.G. White and M.C. Herzberg. Platelet interaction with bacteria. VI. Contrasting the role of fibrinogen and fibronectin. Am. J. Hematol. 9:43-53, 1980.

Herzberg, M.C. and R.V. Katz. Future faculty training requirements and job opportunities: A survey of U.S. dental school deans. J. Dent. Educ. 46:261-265, 1982.

Herzberg, M.C., K.L. Brintzenhofe and C.C. Clawson. Aggregation of human platelets and adhesion of S. sanguis. Infect. Immun. 39:1457-1469, 1983.

Herzberg, M.C. and K.L. Brintzenhofe. ADP-like platelet aggregation activity generated by viridans streptococci incubated with exogenous ATP. Infect. Immun. 40:120-125, 1983.

Herzberg, M.C., K.L. Brintzenhofe and C.C. Clawson. Cell-free released components of S. sanguis inhibit human platelet aggregation. Infect. Immun. 42:394-401, 1983.

MacFarlane, G.D. and M.C. Herzberg. Concurrent estimation of the kinetics of adhesion and ingestion of Staphylococcus aureus by polymorphonuclear leukocytes. J. Immunol. Methods 66:35-49, 1984.

Lareau, D.E., M.C. Herzberg and R.D. Nelson. Human neutrophil migration under agarose to bacteria associated with the development of gingivitis. J. Periodontol. 55:540-549, 1984.

MacFarlane, G.D., M.C. Herzberg and R.D. Nelson. Analysis of polarization and orientation of human polymorphonuclear leukocytes by computer-interfaced video microscopy. J. Leukocyte Biol. 41:307-317, 1987.

Soberay, A.H., M.C. Herzberg, J.D. Rudney, J.J. Sixma, K. Nieuwenhuis and U. Seligsohn. Responses of platelets to strains of Streptococcus sanguis: Findings in healthy subjects, Bernard-Soulier, Glanzmann's and collagen-unresponsive patients. Thromb. Haemost. 57:222-225, 1987.

Erickson, P.R. and M.C. Herzberg. A collagen-like immunodeterminant on the surface of Streptococcus sanguis induces platelet aggregation. J. Immunol. 138:3360-3366, 1987.

Herzberg, M.C., K. Gong, G.D. MacFarlane, A.H. Soberay, P.H. Krebsbach, G. Manjula, K. Schilling and W.H. Bowen. Phenotypic characterization of virulence factors associated with bacterial endocarditis on strains of Streptococcus sanguis. Infect. Immun. 58:515-522, 1990.

Erickson, P.R. and M.C. Herzberg. Purification and partial characterization of a platelet interactive antigen from the surface of Streptococcus sanguis. J. Biol. Chem. 265:14080-14087, 1990

Cai-fang, C., M.C. Herzberg and G.D. MacFarlane. Relationship between serum antibody to Bacteroides gingivalis and clinical parameters in periodontitis patients. Chinese J. Stomatol. 25:197-200 (abstract in English, p. 251), 1990.

Herzberg, M.C., P.R. Erickson, P.K. Kane, D.J. Clawson, C.C. Clawson and F.A. Hoff. Platelet interactive products of Streptococcus sanguis protoplasts. Infect. Immun. 58:4117-4125, 1990.

Erickson, P.M., M.C. Herzberg and G. Tierney. Cross-reactive immunodeterminants on Streptococcus sanguis and collagen: Predicting a structural motif of platelet-interactive domains. J. Biol. Chem. 267:10018-10023, 1992.

MacFarlane, G.D., M.C. Herzberg, L.F. Wolff and N.A. Hardie. Refractory periodontitis associated with abnormal polymorphonuclear leukocyte phagocytosis and cigarette smoking. J. Periodontol. 63:908-913, 1992. (Winner, Clinical Research Award in Periodontology, American Academy of Periodontology, 1993)

Herzberg, M.C., G.D. MacFarlane, K. Gong, A.R. Witt, P.R. Erickson, and M.W. Meyer. Platelet interactivity phenotype of Streptococcus sanguis influences the course of experimental endocarditits. Infect. Immun. 60: 4809-4818, 1992.

Erickson, P.R. and M.C. Herzberg. The Streptococcus sanguis platelet-aggregation-associated protein: Identification and characterization of the minimal platelet-interactive pepetide. J. Biol. Chem. 268:1646-1649, 1993.

Herzberg, M.C., L.K. Krishnan and G.D. MacFarlane. Involvement of a2-adrenoreceptors and G-proteins in the modulation of platelet secretion in response to Streptococcus sanguis [a research report]. Crit. Rev. Oral Biol. 4:435-442, 1993.

Govze, Y. and M.C. Herzberg. Anti-desmosomal antibodies in periodontitis. J. Periodontol. 64:603-608, 1993.

Erickson, P.E. and M.C. Herzberg. Evidence for the covalent linkage of carbohydrate polymers to a glycoprotein from Streptococcus sanguis. J. Biol. Chem. 268: 23780-23783, 1993.

Stoltenberg, J.L., J.B. Osborn, B.L. Pihlstrom, M.C. Herzberg, D.M. Aeppli, L.F. Wolff and G.E. Fischer. Association between cigarette smoking, bacterial pathogens and periodontal status. J. Periodontol. 64:1225-1230, 1993.

MacFarlane, G.D., D.E. Sampson, D.J. Clawson, C.C. Clawson, K.L. Kelly and M.C. Herzberg. Evidence for an ecto-ATPase on the cell wall of Streptococcus sanguis. Oral Microbiol. Immunol. 9:180-185, 1994.

Seow, W.K., Y.H. Thong, R.D. Nelson, G.D. MacFarlane and M. C. Herzberg. Nicotine-induced release of elastase and eicosanoids by human neutrophils. Inflammation 18:119-127, 1994.

Herzberg, M.C., G.D. MacFarlane, P. Liu and P.R. Erickson. The platelet as an inflammatory cell in periodontal diseases: Interactions with Porphyromonas gingivalis. In: Molecular Basis for Pathogenesis and Targetting in Periodontal Diseases. S. Mergenhagen, J. McGhee, T. Lehner, S. Hamada and R.J. Genco, eds. Am. Soc. Microbiol. Washington DC, 247-255, 1994.

Meyer, M.W., Witt, A.R., Krishnan, L.K., Rudney, J.D., Yokota, M.J. & Herzberg, M.C. Therapeutic advantage of recombinant human plasminogen activator in endocarditis: Evidence from experimental rabbits. Thromb Haemost 73:680-682, 1995.

Erickson, P.R. & Herzberg, M.C. Altered expression of the platelet aggregation-associated protein (PAAP) from Streptococcus sanguis after growth in the presence of collagen. Infect Immun 63:1084-1088, 1995.

Gong, K., Wen, D.Y., Ouyang, T., Rao, A.T. & Herzberg, M.C. Platelet receptors for the Streptococcus sanguis adhesin and aggregation-associated antigens are distinguished by anti-idiotypical monoclonal antibodies. Infect Immun 63:3628-3633, 1995.

Herzberg, M.C. & Meyer, M.W. Effects of oral flora on platelets: Possible consequences in cardiovascular disease. J Periodontol 67:1138-1142, 1996.

Herzberg, M.C. Platelet-streptococcal interactions in endocarditis [a review]. Crit Rev Oral Biol Med 7:222-236, 1996.

Herzberg, M.C., Meyer, M.W., Kilic, A., & Tao, L. Host-pathogen interactions in bacterial endocarditis: Streptococcal virulence in the host. Adv Dent Res 11:69-74, 1997.

Gong, K. & Herzberg, M.C. Streptococcus sanguis expresses a 150-kilodalton two-domain adhesin: Characterization of several independent adhesin epitopes. Infect Immun 65:3815-3821, 1997.

Herzberg, M.C. & Meyer, M.W. Dental plaque, platelets and cardiovascular diseases. Annals Periodontol 3:151-160, 1998.

Gong, K., Ouyang, T., & Herzberg, M.C. A streptococcal adhesion system for salivary pellicle and platelets. Infect Immun 66: 5388-5392, 1998.

Meyer, M.W., Gong, K, & Herzberg, M.C. Streptococcus sanguis-induced platelet clotting in rabbits and hemodynamic and cardiopulmonary consequences. Infect Immun 66: 5906-5914, 1998.

Erickson, P.R. & Herzberg, M.C. Emergence of antibiotic resistant Streptococcus sanguis in dental plaque of children after treatment for otitis media. Pediatric Dentistry 21:181-185, 1999.

Tao, L., & Herzberg, M.C. Identifying in vivo-expressed streptococcal genes in endocarditis. Meth Enzymol: 310:109-116, 1999.

Kiliç, A., Herzberg, M.C., Meyer, M.W., Zhao, Z., & Tao, L. Streptococcal reporter gene-fusion vector for identification of in vivo-expressed genes. Plasmid 42:67-72, 1999.

Gong, K., Mailloux, L., & Herzberg, M. C. Salivary film expresses a complex, macromolecular binding site for Streptococcus sanguis. J. Biol. Chem. 275:8970-8974, 2000.

Ross, K.F. & Herzberg, M.C. Calprotectin expression by gingival epithelial cells. Infect Immun 69: 3248-3254, 2001.

Nisapakultorn, K., Ross, K.F. & Herzberg, M.C. Calprotectin expression inhibits bacterial binding to mucosal epithelial cells. Infect Immun 69: 3692-3696, 2001.

Nisapakultorn, K., Ross, K.F. & Herzberg, M.C. Calprotectin expression in vitro by oral epithelial cells confers resistance to infection by Porphyromas gingivalis. Infect Immun 69: 4242-4247, 2001.

Yokota, M., Basi, D.L., Herzberg, M.C., Meyer, M.W. Anti-fibrin antibody binding in valvular vegetations and kidney lesions during experimental endocarditis. Microbiol Immunol 46: 699-707, 2001.

Herzberg, M.C. Coagulation and thrombosis in cardiovascular disease: plausible contributions of infectious agents. Ann Periodontol 6: 16-19, 2001.

Costalonga, M., Hodges, J.S. & Herzberg, M.C. Streptococcus sanguis modulates type II collagen-induced arthritis in DBA/1J mice. J Immunol: 169:2189-2195, 2002.

Basi, D.L., Ross, K.F., Hodges, J.S. & Herzberg, M.C. The modulation of tissue factor by endothelial cells during heat shock. J Biol Chem 278:11065-71, 2003.

Zhang, Y., Lei, Y., Khammanivong, A., & Herzberg, M.C. Identification of a novel two-component system in Streptococcus gordonii V288 involved in biofilm formation. Infect Immun 72:3489-3494, 2004

Kiliç, A.O., Tao, L., Zhang, Y., Lei, Y., Khammanivong, A., & Herzberg, M.C. Involvement of Streptococcus gordonii beta-glucoside metabolism systems in adhesion, biofilm formation and in vivo gene expression. J Bacteriol 186:4246-4253, 2004.

Zhang, Y., Lei, Y., Nobbs, A., Khammanivong, A., Herzberg, M.C. Inactivation of S. gordonii SspAB alters expression of multiple adhesin genes. Infect Immun 73: 3351-3357, 2005

Herzberg, M.C., Nobbs, A., Tao, L., Kiliç, A., Beckman, E., Khammanivong, A., and Zhang, Y. Oral streptococci and cardiovascular disease: putative mechanisms of S. sanguis-induced thrombosis. J Periodontol, 76 (11 Suppl):2101-5, 2005.

Kumar, R.B., Maher, D.M., Herzberg, M.C., and Southern, P.J. Expression of HIV receptors, alternate receptors and co-receptors on tonsillar epithelium: implications for HIV binding and primary oral infection. Virology J, 2006 Apr 6;3(1):25 [Epub ahead of print]

Herzberg, M.C., Weinberg, A., Wahl, S.M. The oral epithelial cell and first encounters with HIV-1. Advances in Dental Research, 19: 158-166, 2006.

Kuboniwa, M, Tribble, G.D., James, C.E., Kilic, A.O., Tao, L., Herzberg, M.C., Shizukuishi, S., and Lamont, R.J. Streptococcus gordonii utilizes several distinct gene functions to recruit Porphyromonas gingivalis into a mixed community. Molec Microbiol 60:121-139, 2006.

Nobbs, A.H., Zhang,, Y., Khammanivong, A., Herzberg, M.C. Streptococcus gordonii Hsa environmentally constrains competitive binding by Streptococcus sanguinis to saliva-coated hydroxyapatite. J Bacteriol 189: 3106-3114, 2007.

Bando, M., Hiroshima, Y., Kataoka, M., Shinohara, Y., Herzberg, M.C., Ross, K.F., Nagata, T., Kido, J. Interleukin-1a regulates antimicrobial peptide expression in human keratinocytes. Immunology and Cell Biology 85:532-7, 2007.

Giacaman, R.A., Nobbs, A.H., Ross, K.F. and Herzberg, M.C. Porphyromonas gingivalis selectively up-regulates the HIV-1 co-receptor CCR5 in oral keratinocytes. J Immunol 179: 2542-2550, 2007.

Nobbs, A.H., Vajna, R.M., Johnson, J.R., Zhang, Y., Erlandsen,S.L., Oli, M.W., Kreth,J., Brady, L.J., and Herzberg, M.C. Consequences of a sortase A mutation in Streptococcus gordonii. Microbiology 153(Pt 12):4088-97, 2007.

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