Sven-Ulrik Gorr

Sven-Ulrik Gorr

Academic Title

Associate Dean for Research
Professor
Division of Basic Sciences
Department of Diagnostic and Biological Sciences

Education

Ph.D.
Biochemistry, Ph.D., University of Copenhagen, 1990
Other Education
Cand. Scient (MSc) Biochemistry, University of Copenhagen (Denmark), 1984

Contact Info

Email
sugorr@umn.edu

Phone
612-626-5728

Fax
612-625-6948

Administrative Contact

Jane Franklin
612-626-5731
fran0324@umn.edu

Office Address

18-208 Moos Tower
515 Delaware St. SE
Minneapolis, MN 55455

Research Interests

The long-term goal of our laboratory is to determine the biological role of Parotid Secretory Protein (PSP; BPIFA2) as an oral and systemic anti-inflammatory protein. PSP is expressed in salivary glands, oral epithelial cells and saliva and its expression is up-regulated by bacteria and TNF. An in silico structural analysis of PSP revealed that it may be similar to Bactericidal/Permeability Increasing protein (BPI) and Lipopolysaccharide (LPS)-Binding Protein (LBP). Indeed, recent evidence from our laboratory suggests that PSP binds LPS and prevents systemic inflammation in vivo. Guided by the location of active domains in BPI and LBP, several PSP peptides were designed and found to exhibit both antibacterial and anti-endotoxin activities in vitro and in vivo. Modified PSP peptides have been designed that show enhanced antibacterial activity and selectivity for certain bacterial species. Future goals include understanding the biological activity of PSP in vivo and optimization of PSP peptides as selective antimicrobial peptides with low host toxicity.

Patent: US 8,569,449 B2 Synthetic peptides and peptide mimetics

 

Publications

Fasciotto BH, Kuehn U, Cohn DV, Gorr S-U. Secretory cargo composition affects polarized secretion in MDCK epithelial cells. Mol. Cell. Biochem. 310:67-75 (2008)

Kinane, D. F. Galicia, J. Gorr, S. U. Stathopoulou, P. Benakanakere, M. M. P. gingivalis interactions with epithelial cells. Front. Biosci. 13: 966-984 (2008).

Gorr S-U, Sotsky JB, Shelar AP, Demuth DR. Design of bacteria-agglutinating peptides derived from Parotid Secretory Protein, a member of the Bactericidal/Permeability Increasing-like protein family. Peptides, 29:2118-2127 (2008) PMID:18952131

Hu S, Zhou M, Jiang J, Wang J, Elashoff D, Gorr S, Michie SA, Spikervet FKL, Bootsma H, Kallenberg CGM, Vissink A, Horvath S, Wong DT. Systems Analysis of Sjögren’s Syndrome and MALT Lymphoma Development in Parotid Glands. Arthritis and Rheumatism, 60:81-92 (2009) PMCID: PMC2718690

Gorr S-U. Antimicrobial peptides of the oral cavity. Periodontology 2000. 51:152-180 (2009). PMID:19878474

Gorr S-U, Abdolhosseini M. Antimicrobial peptides and periodontal disease. Journal of Clinical Periodontology, 38 (suppl. 11): 126-141 (2011). PMID:21323710

Gorr S-U., Abdolhosseini M., Shelar A., Sotsky, J., Dual host-defence functions of SPLUNC2/PSP and synthetic peptides derived from the protein. Biochemical Society Transactions, 39(4): 1028-1032 (2011). PMID:21787342

Biswas S, Knipp RJ, Gordon LE, Nandula SR, Gorr SU, Clark GJ, Nantz MH Hydrophobic Oxime Ethers: A Versatile Class of pDNA and siRNA Transfection Lipids. ChemMedChem. 6: 2063-2069 (2011). PMID:21882348

Gorr S-U. Antimicrobial peptides in periodontal innate defense, Frontiers in Bioscience, 15: 84-98 (2012). PMID:22142958

Abdolhosseini M, Sotsky JB, Shelar AP, Joyce PB, Gorr SU. Human parotid secretory protein is a lipopolysaccharide-binding protein: identification of an anti-inflammatory peptide domain. Mol Cell Biochem. 359:1-8 (2012). PMID:21833535

Abdolhosseini M, Nandula SR, Song J, Hirt H, Gorr SU. Lysine substitutions convert a bacterial-agglutinating peptide into a bactericidal peptide that retains anti-lipopolysaccharide activity and low hemolytic activity. Peptides. 35:231-238 (2012). PMID:2248428

Gorr S-U, Wennblom TJ, Horvath S, Wong DTW, Michie SA. Text-mining applied to autoimmune disease research: The Sjogren's Syndrome Knowledge Base. BMC Musculoskeletal Disorders, 13:119 (2012). PMID:22759918

Horvath S, Nazmul-Hossain AN, Pollard RP, Kroese FG, Vissink A, Kallenberg CG, Spijkervet FK, Bootsma H, Michie SA, Gorr SU, Peck AB, Cai C, Zhou H, Wong DT. Systems analysis of primary Sjögren's syndrome pathogenesis in salivary glands identifies shared pathways in human and a mouse model. Arthritis Res Ther. 14:R238 (2012) . PMID: 23116360

Mestres G, Abdolhosseinin M, Bowles W, Huang SH, Aparicio C, Gorr SU, Ginebra MP. Antimicrobial properties and dentin bonding strength of magnesium phosphate cements. Acta Biomaterialia, 9:8384-8393 (2013). PMID:23747324

Holmberg KV, Abdolhosseini M, Li Y, Chen X, Gorr SU, Aparicio C. Bio-inspired stable antimicrobial peptide coatings for dental applications. Acta Biomater. 9:8224-8231 (2013). PMID:23791670

Balhara V, Schmidt R, Gorr SU, Dewolf C. Membrane selectivity and biophysical studies of the antimicrobial peptide GL13K. Biochim Biophys Acta. 1828(9):2193-203. (2013) PMID:2374736

Hirt H, Gorr SU. Antimicrobial peptide GL13K is effective in reducing biofilms of Pseudomonas aeruginosa. Antimicrob Agents Chemother. 57(10):4903-4910 (2013). PMID:23917321

 

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