School of Dentistry


Minnesota Dental Research Center for Biomaterials and Biomechanics

Artificial Caries and Remineralization

Artificial Caries and Remineralization

An in-vitro biophysical assay that simulates and measures the progress of caries formation has been developed. It forms an essential tool for the development and assessment of preventive and therapeutic agents. The extent of the de/remineralization is determined by the total amount of mineral loss, calculated from local mineral content of tooth structures. We use serial microhardness to calculate mineral content in enamel lesions. For dentin lesions, mineral content is converted from X-ray density (micro-radiography). The total amount of mineral loss is determined by comparing the mineral content in a lesion area with that of healthy tooth structures.


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  • Last modified on August 29, 2012