Biofunctional surfaces to induce rapid bone integration of dental and maxillofacial implants
Commercially pure titanium (cp Ti) dental implants have been widely and successfully used with high rates of clinical success. However, there is still a lack of reliable synthetic materials to be used either a) when immediate loading of the implant is desired or b) when bone presents compromised conditions due to trauma, infection, systemic disease and/or lack of significant bone volume.
We are developing biomimetic strategies of surface modification to obtain metallic implants with osteostimulative capabilities. These surface modifications will provide implants with a rapid rate of new bone growth and with osseocoalescence, i.e. direct chemical contact with the surrounding tissues. Different chemical and biochemical surface treatments have already been successfully developed. The resulting biomimetically-modified implants can be reliably used in those more demanding clinical situations.
Above: Confocal laser microscopy images of surfaces (in grey) that have been treated to induce rapid extracellular matrix deposition (fibrils of fibronectin in green) by osteoblasts-like cells.