Bone Biology and Craniofacial Development

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Bone Biology and Craniofacial Development

Research in this cluster ranges from basic bone biology to periodontal disease and dental implants. Investigators collaborate to study the mechanisms of cellar differentiation responsible for bone resorption and deposition. With a more complete understanding of these processes, they are working to reduce the rate of bone loss and possibly assist in restoring structures to their premorbid condition. Using genetically modified animals, these researchers are able to induce specific defects in developing structures of the orofacial region and are beginning to construct models to explain the roles individual genes play in the formation of these structures. This research on bone biology has implications for dental implants, periodontal health, oral pathology, oral surgery, endodontics, and orthodontics. Research projects investigate the role of a bone morphogenetic protein-binding protein in skeletal development and remodeling; inhibitory mechanisms in differentiation of osteoblasts; periodontal disease as a risk factor for osteonecrosis of the jaw; and characterization of embryonic stem cells with potential to differentiate and form bone in vivo. Research in the area of orthodontics investigates the role of masticatory load and data analysis in 3-D digital imaging.

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  • Last modified on August 28, 2012