Oral Infections and Microbiology

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Oral Infections and Microbiology

Caries and other oral infections are key problems facing dental practitioners. Accordingly, research in this area has a long tradition at the School of Dentistry. Current research projects focus on how to make the oral mucosa more resistant to invasive oral pathogens by increased production of normal antimicrobial effector molecules in oral mucosal epithelial cells; design of antimicrobial peptides based on salivary host-defense proteins; and studies on the interaction between oral biofilms and dental resin with the goal to increase the service life of dental resin composite restorations. Virology has long been a signature program of the school of dentistry. With over 40 years of continuous NIH funding to study how bacterial viruses invade healthy cells, replicate, release themselves into the environment via promotion of host bacterial lysis, researchers in the School of Dentistry have established themselves as major contributors to the field. They have helped unravel many of the mysteries associated with this infectious process. Their discoveries have suggested new approaches to developing anti-viral drugs and other therapies to treat patients.

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  • Last modified on August 28, 2012