Clinical Studies

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Clinical Studies

Currently enrolling clinical studies:
DPTT (Diabetes and Periodontal

This study is no longer recruiting subjects and is in the data analysis phase to end on June 30, 2013. Volunteers were recruited to determine if non-surgical periodontal (gum) therapy improves blood sugar control in patients with type 2 diabetes and periodontitis (gum disease). Participants were randomly assigned to receive gum therapy at the start of the study or after 6 months.

Participants were required to be:

  1. Be 35 years of age or older.
  2. Have a HbA1c value between 7.0 and 8.9%.
  3. Have had type 2 diabetes for more than 3 months.
  4. Have at least sound 16 natural teeth.

Participants received gum treatment at no cost and are given a $25 gift card at the completion of each of 6-8 study visits over a 6-month period.

Anti-CCP Antibody Prevalence in a Periodontitis Cohort

Volunteers are needed to determine if periodontal (gum disease) increases one’s chances of developing antibodies that may lead to rheumatoid arthritis.

Participants must:

  1. Be 18 years of age or older.
  2. Have moderate to advanced periodontal disease.
  3. Have no history or family history of rheumatoid arthritis.

Participants will receive a free clinical examination and $50 for their participation.

Call Ms. Patt Carlson at 612-626-3736 for more information or to determine if you might qualify for this study.

Bisphosphonate-Associated Osteonecrosis: Periodontal Disease as a Risk Factor for ONJ

Purpose: The goal of this application is to perform a matched case-control study to test the hypothesis that periodontitis is a risk factor in the development of bisphosphonate-associated osteonecrosis of the jaw (ONJ).
Participants must:

  1. Be 30 years of age or older.
  2. Be under the care of a physician for cancer.
  3. Currently taking or have been treated with bisphosphonate like Aredia/Pamidronate and Zometa/Zoledronate for at least 6 months.
  4. Case – subject has osteonecrosis of the jaw by dental examination or record.

Participants receive dental examination (one time visit) at no cost and are given a $50 compensation for their time and effort.
Call 612-625-6155/612-624-0918 for more information or to determine if you might qualify for the trial.

IMPACT (TMJ Intra-Articular Disorders: Impact on Pain, Functioning and Disability)

Persons who previously participated in Dr. Schiffman’s RDC: Reliability and Validity Study between the years of 2003 and 2006 will be invited to undergo a follow-up clinical examination of their jaw-joints and muscles, complete a series of questionnaires, and have images and MRIs of their jaw-joints. This follow up information will then be compared to their initial data to determine to what degree a disorder in the TMJ (jaw-joint) may have a significant impact on jaw pain, jaw function (eating, mouth opening, etc.) and, as a result, any individual disability.

Participants must:

  1. Have participated in the “RDC (Research Diagnostic Criteria): Reliability and Validity” Study between the years of: 2003 - 2006.
  2. Be able/willing to have CT scans and MRIs of their jaw-joints.
  3. Be able/willing to come to the School of Dentistry for their appointments.
  4. Be willing to complete the study questionnaires prior to their dental examination.\

Participants will receive $200 to compensate them for their time and inconvenience and to cover their parking expenses.

Call 612-624-9669 for more information.

Comparison of Initial Implant Stability of Posterior Maxillary Implants with Bicortical Fixation to Implants Engaging Only the Alveolar Crest

Volunteers are invited to participate in a research comparing different techniques for placing dental implants in the back part of your upper jaw when a limited amount of bone is present.

Participants must:

  1. Be over 18 years or older.
  2. Missing one or two teeth in the back part of the upper jaw
  3. Have between 7 mm and 11mm of bone from the alveolar crest to the sinus floor in the back part of your upper jaw (determined at the U of M School of Dentistry by study investigators)
  4. Be able to return to the University for multiple appointments (approximately 10-15) over a 5-year period.

Although the cost of the CBCT imaging and dental implant hardware will be covered by the study, the patient will still be financially responsible for the surgery and restorative portion of the implant treatment which will amount to approximately $2,000. At the one year follow up appointment the patient will receive $30.

Email wolf0400@umn.edu for more information or to determine if you might qualify for the trial.

Multi-Center Phase 3 Trial of Minocycline HC1mg Microspheres for the Use in Subjects with Peri-Implantitis

We are conducting a clinical trial to determine if deep cleaning plus a locally delivered antibiotic (placed into the gum) is more effective than deep cleaning alone for the treatment of peri-implantitis. Participants are randomly assigned to a treatment group – they cannot choose to be in one group or the other.

Eligible participants must be:

  • At least 21 years of age and in good general health
  • Willing to adhere to the study schedule, prohibitions and restrictions specified in the protocol
  • Male subjects who are not surgically sterilized must be practicing an effective method of birth control for the duration of the study
  • Female subjects must be either at least 65 years of age and post-menopausal for at least two years, or surgically sterile, or abstinent, or if sexually active, be practicing an effective method of birth control
  • At least one dental implant with a diagnosis of peri-implantitis (loss of bone support with soft tissue pocketing) as defined by the study protocol

The following patients are ineligible:

  • Women who are pregnant, lactating or planning to become pregnant soon
  • Male subjects reporting pregnancy or lactation of their partner
  • Subjects reporting allergy to a tetracycline-class drug
  • Subjects with any systemic medical conditions requiring antibiotic prophylaxis prior to invasive dental procedures
  • Subjects who have participated in a dental clinical trial within 30 days of enrollment
  • Subjects presenting with signs of untreated advanced periodontal disease and/or poor oral hygiene

The trial lasts 6 months. Participants are seen for 3-4 study visits, receive free non-surgical peri-implantitis treatment and paid $50 for each visit. For more information, contact Ms. Carol Dunn, Study Coordinator at 612-624-8998.

Understanding the impacts of, and screening for, Atypical Odontalgia

Volunteers are invited to participate in this research study of how persistent tooth pain effects your life and how best to screen for these conditions. The purpose of this study is to determine how well a screening instrument works to identify patients with atypical, or unusual tooth pain.

Participants are required to:

Be diagnosed with tooth pain, related pain or be pain-free.

Study Procedures

If you agree to participate in the study, you will be asked to:

  1. Participate by filling our 6 questionnaires that will take about half an hour of your time.

A check for $25 will be mailed to participants within 2 weeks following their participation. Call Dr. Donald Nixdorf at 612-626-5407 for more information or to determine if you might qualify for this study.

 

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  • Last modified on September 17, 2013