Conrado Aparicio, PhD, MSc Eng

Associate Professor, Department of Restorative Sciences

Conrado Aparicio

Contact Info

apari003@umn.edu

Office Phone 612-625-4467

Fax 612-626-1484

Office Address:
16-250A Moos Tower
515 Delaware St. SE
Minneapolis, MN 55455

PhD, Technological Univ. Catalonia, Spain (Biomaterials), 2004

MScEng, Technological Univ. Catalonia, Spain (Materials Engineering), 1998

Post Doc, Northwestern University (Regenerative Medicine), 2007

Summary

Dr Conrado Aparicio is an investigator with a research focus on the surfaces of dental biomaterials, their design, modification, as well as the characterization and analysis of their physical, chemical, mechanical, and biological properties. He is a materials engineer by training and performed his PhD under the supervision of Professor Javier Gil at BarcelonaTech-UPC developing new surface treatments to improve osseointegration of dental implants.

After getting his position as a senior lecturer in Spain, Dr Aparicio moved to Chicago where he was a visiting scholar at the Institute for BioNanotechnology in Medicine of Northwestern University under the supervision of Professor Samuel Stupp. Dr Aparicio investigated the biomineralization of self-assembled nanostructured scaffolds made of peptide-amphiphiles.

Dr Aparicio’s main subjects of research are the understanding of the interactions between biological and synthetic materials, biofunctionalization of biological and synthetic surfaces with biomolecules for improving bioactivity and antimicrobial properties of different dental biomaterials, and biomineralization of biomaterials.

Recently, Dr Aparicio’s research interests have expanded to studying and developing new techniques and new biomaterials, including 1) dental restorative materials and biological agents to induce bone regeneration and teeth remineralization; and 2) new materials and methodologies for the assessment, management, and improvement of esthetic dental restorations.

Dr Aparicio’s background and record of scholarly publications reflects a multi- and interdisciplinary approach to biomaterials and biomechanics science and engineering, including several biomolecular, in vitro and in vivo studies.

Awards & Recognition

  • Beta Beta Chapter of Omicron Kappa Upsilon National Dental Honor Society, Honorary member
  • IRBM-Innovation and Research in Biomedical Engineering, Elsevier Journal, Associate Editor
  • University of Minnesota School of Dentistry Paper of the Year Award, 2013, 2014
  • DDS and DT Class of 2016 and 2014 Didactic Faculty Member of the Year (D2, DT2). School of Dentistry. University of Minnesota, 2013.
  • 9th World Biomaterials Congress, Rapid-Fire Poster Presentation Award
  • 3M Non-tenured Faculty Award
  • Best PhD Dissertation in Chemistry or Materials Science, 2004/2005
  • City of Barcelona Award for Technological Research, 2006 
  • 2005 European Basic Research in Odontology Award
  • Journal of Materials Science: Materials in Medicine Best Paper Award, 2002

Professional Associations

  • IADR – International Association for Dental Research, Heraeus Travel Awards Committee, Subgroup Chair-Dental Materials: Biocompatibility
  • AADR – American Association for Dental Research, Subgroup Chair-Dental Materials: Biocompatibility
  • European Society for Biomaterials, Annual Meeting International Advisory Board
  • World Bioceramics Conference, Annual Meeting International Advisory Board
  • Society for Biomaterials, Member
  • Materials Research Society, Member
  • Dental Materials Academy, Member

Research

Research Summary/Interests

  • Surface modification for dental and orthopedic implants
  • Biomineralization of synthetic materials and tissues
  • Biomimetic systems for biomedical applications
  • Development and evaluation of dental restorative materials
  • Regeneration of hard tissues (enamel, dentin, bone)
  • Dental biofilms
  • Synthetic peptides, recombinant biopolymers, and self-assembly

Publications

Last 5 years

G. Kotsakis, C. Lan, J. Barbosa, K. Lill, R. Chen, J. Rudney, C. Aparicio. Antimicrobial agents used in the treatment of peri-implantitis alter the physicochemistry and cytocompatibility of titanium surfaces. Journal of Periodontology. DOI:10.1902/jop.2016.150684.

P. Sevilla, K.V. Holmberg, J. Dotor, D. Rodriguez, F.J. Gil, C. Aparicio. Surface immobilization and bioactivity of TGF-?1 inhibitor peptides for bone implant applications. Journal of Biomedical Materials Research B: Applied Biomaterials (2016) 104B: 385-394.

Biomineralization and Biomaterials. Fundamentals and Applications. Eds, C. Aparicio, M.P. Ginebra. Woodhead Publishing. Inc. – Elsevier (2015). ISBN: 978-1-78242-338-6.

Y. Li, X. Chen, A. Fok, J.C. Rodriguez-Cabello, C. Aparicio. Biomimetic Mineralization of Recombinamer-Based Hydrogels toward Control Morphologies and High Mineral Density. ACS Applied Materials and Interfaces (2015) 7(46):25784–25792.

E. Fernandez-Garcia, X. Chen, C.F. Gutierrez-Gonzalez, A. Fernandez, S. Lopez-Esteban, C. Aparicio. Peptide-functionalized Zirconia and New Zirconia/Titanium Biocermets for Dental Applications. The Journal of Dentistry (2015) 43(9):1162-1174.

K. Riccardi, J.M. Manero, Y. Li, C. Aparicio, F.J. Gil, E. Ruperez. Development of a tantalum scaffold for orthopaedic applications produced by space-holder method. Materials & Design (2015) 83: 112-119.

Y. Li, C. Carrera, R. Chen, J. Li, Y. Chen, P. Lenton, J.D. Rudney, R.S. Jones, C. Aparicio, A. Fok. Fatigue failure of dentin-composite disks subjected to cyclic diametral compression. Dental Materials (2015) 31(7):778-788.

C.A. Carrera, C. Lan, D. Escobar-Sanabria, Y. Li, J. Rudney, C. Aparicio, A. Fok. The Use of Micro-CT with Image Segmentation to Quantify Leakage in Dental Restorations. Dental Materials (2015) 31(4):382-390.

X. Chen, H. Hirt, Y. Li, S.-U. Gorr, C. Aparicio. Antimicrobial GL13K peptide coatings killed and ruptured the wall of Streptococcus gordonii and prevented formation and growth of biofilms. PLOS ONE (2014). 9(11):e11579.

N. Marín-Pareja, E. Salvagni, J. Guillem-Marti, C. Aparicio, M.P. Ginebra. Collagen-functionalized titanium surfaces for biological sealing of dental implants: Effect of immobilization process on fibroblasts response. Colloids and Surfaces B: Biointerfaces (2014) 122:601-610.

Y. Li, X. Chen, A. Ribeiro, E. Jensen, K.H. Holmberg. J.C. Rodriguez-Cabello, C. Aparicio. Hybrid nanotopographic surfaces obtained by biomimetic mineralization of statherin-inspired elastin-like recombinamers. Advanced Healthcare Materials (2014) 3:1638-1647.

E. Salvagni, G.Y. Berguig, E. Engel, J.C. Rodriguez-Cabello, G. Coullerez, M. Textor, F.J. Gil, J.A. Planell, C. Aparicio. A bioactive elastin-like recombinamer reduces unspecific protein adsorption and enhances cell response on titanium surfaces. Colloids and Surfaces B: Biointerfaces (2014) 114: 225-233.

Y. Li, C. Carrera, R. Chen, J. Li, P. Lenton, J.D. Rudney, R.S. Jones, C. Aparicio, A. Fok. Interfacial Degradation in Composite Restorations Subjected to Multi-Species Biofilm Challenges. Acta Biomaterialia (2014) 10:375-383.

D. Isfeld, C. Aparicio, R.S. Jones. Assessing near Infrared Optical Properties of Ceramic Orthodontic Brackets using Cross-Polarization Optical Coherence Tomography. Journal of Biomedical Materials Research B (2014) 102:516-523.

F.J. Gil, N. Manzanares, A. Badet, C. Aparicio, M.P. Ginebra. Biomimetic Treatment of Dental Implants for Short-Term Bone Regeneration. Clinical Oral Investigations (2014) 18:59-66.

Y. Li, C. Aparicio. Visualizing the subfibrillar structure of mineralized collagen fibrils: A model of the ultrastructure of bone. PLoS ONE (2013) 8(9): e76782.

K.V. Holmberg, M. Abdolhosseini, X. Chen, E. Jensen, Y. Li, S.-U. Gorr, C. Aparicio. Bio-inspired Antimicrobial Peptide Coating for Dental Implants. Acta Biomaterialia (2013) 9(9): 8224-31.

G. Mestres, M. Abdholosseini, W. Bowles, C. Aparicio, S.-U. Gorr, M.P. Ginebra. Dentin bonding strength and antimicrobial properties of magnesium phosphate cements for endodontic applications. Acta Biomaterialia (2013) 9(9):8384-93.

X. Chen, P. Sevilla, C. Aparicio. Surface biofunctionalization by covalent co-immobilization of oligopeptides. Colloids and Surfaces B: Biointerfaces. (2013) 107:189-97.

X. Chen, Y. Li, C. Aparicio. Biofunctional Coatings for Dental Implants. In Thin Films and Coatings in Biology. Biological and Medical Physics -Biomedical Engineering Series; ed. S. Nazarpour. Springer-Verlag. ISBN 978-94-007-2592-8. pp 105-143.

C. Mas-Moruno, M. Espanol, E.B. Montufar, G. Mestres, C. Aparicio, F.J Gil, M.P. Ginebra. Bioactive metallic and ceramic surfaces for bone engineering. In Biomaterials Surface Science; eds. A. Taubert, J.F. Mano, J.C. Rodriguez-Cabello. Willey. ISBN 978-35-273-3031-7. pp 337-374.

J.D. Rudney, R. Chen, P. Lenton, J. Li, Y. Li, R.S. Jones, C. Reilly, A.S. Fok, C. Aparicio. Reproducible Oral Microcosm Biofilm Model for Testing Dental Materials Journal of Applied Microbiology (2012) 113(6):1540-53.

M. Pegueroles, Ch. Tonda, E. Engel, J.A. Planell, C. Aparicio. Adsorption of fibronectin, fibrinogen, and albumin on TiO2: time-resolved kinetics, structural changes, and competition study. Biointerphases (2012) 7:48.

T. Sargeant, C. Aparicio, J. Goldberger, H. Cui, S.I. Stupp. Mineralization of Peptide Amphiphiles Nanofibers and its Effect on Differentiation of Human Mesenchymal Stem Cells. Acta Biomaterialia (2012) 8(7):2456-2465.

P. Lenton, J. Rudney, R. Chen, A. Fok, C. Aparicio, R.S. Jones. Imaging in vivo secondary caries and ex vivo dental biofilms using cross-polarization optical coherence tomography. Dental Materials (2012) 28(7):792-800.

R. Chen, J. Rudney, C. Aparicio, A. Fok, R.S. Jones. Quantifying dental biofilm growth using cross-polarization optical coherence tomography. Letters in Applied Microbiology (2012) 54:537–542.

S.-H. Huang, L.-S. Lin, J. Rudney, R.S. Jones, C. Aparicio, C.-P. Lin, A.S.L. Fok A novel dentin bond strength measurement technique using the composite disk in diametral compression. Acta Biomaterialia (2012) 8(4):1597-1602.

Y. Li, T.T. Thula, S. Jee, S.L. Perkins, C. Aparicio, E.P. Douglas, L.B. Gower. Biomimetic Mineralization of Woven Bone-Like Nanocomposites: Role of Collagen Cross-Links. Biomacromolecules (2012) 13:49-59.

C. Aparicio, Y. Maazouz, D. Yang. Measuring wettability of biosurfaces at the microscale. In Nanotechnology in Regenerative Medicine: Methods and Protocols. Methods in Molecular Biology Vol. 811; eds. M. Navarro, J.A. Planell (2012) Humana Press, Springer-Verlag. ISBN 978-1-61779-387-5. pp. 163-177.

Other relevant publications

C. Aparicio, A. Padros, F.J. Gil. In vivo evaluation of Micro-Rough and Bioactive Titanium Dental Implants using Histometry and Pull-Out Tests. Journal of the Mechanical Behavior of Biomedical Materials (2011) 4:1672-1682.

S. Zhang, M. Greenfield, A. Mata, L. Palmer, R, Bitton, J.R. Mantei, C. Aparicio, M. Olvera, S.I. Stupp. A Self-Assembling Pathway to Aligned Monodomain Gels. Nature Materials (2010) 9:595-601.

A. Mata, Y. Biao, K. Henrikson, C. Aparicio, R. Satcher, S .Stock, S.I. Stupp. Bone regeneration mediated by biomimetic mineralization of a nanofiber matrix. Biomaterials (2010) 31:6004-6012.

M. Pegueroles, C. Aparicio, M. Bosio, E. Engel, F.J. Gil, J.A. Planell, G. Altankov Spatial Organization of Osteoblast Fibronectin-Matrix on Titanium Surface – Effects of Roughness, Chemical Heterogeneity, and Surface Free Energy. Acta Biomaterialia (2010) 6, 291-301.

E. Engel, S. Del Valle, C. Aparicio, G. Altankov, L. Asin, J.A. Planell. M.P. Ginebra Topography mediated ion exchanged modulates osteoblast behaviour in bioactive materials. CPC as a model substrate. Tissue Engineering (2008) 14:1341-1351.

A. Mata, L. Hsu, R. Capito, C. Aparicio, K. Henrikson, S.I. Stupp. Micro-patterning of Bioactive Self-Assembling Gels. (2009) Soft Matter 5:1228–1236.

C. Aparicio, J.M. Manero, F. Conde, M. Pegueroles, J.A. Planell, M. Vallet-Regí, F.J. Gil. Acceleration of apatite nucleation on microrough bioactive titanium for bone-replacing implants. Journal of Biomedical Materials Research Part A (2007) 82A:521-529.

A. Michiardi, C. Aparicio, B. Ratner, J.A. Planell, F.J. Gil.The influence of surface energy on competitive protein adsorption on oxidized NiTi surfaces. Biomaterials (2007) 28: 586-594.

F.J. Gil, J.A. Planell, A. Padrós, C. Aparicio. Effect of shot-blasting and heat treatment on fatigue fracture of titanium dental implants. Dental Materials (2007) 23: 486-491.

A. Michiardi, C. Aparicio, J.A. Planell, F.J. Gil. New oxidation treatment of NiTi shape memory alloys to obtain Ni-free surfaces and improve biocompatibility. Journal of Biomedical Materials Research Part B: Applied Biomaterials (2006) 77B:249-256.

M. Navarro, C. Aparicio, M. Charles-Harris, M.P. Ginebra, E.Engel, J.A. Planell. Development of a biodegradable composite scaffold for bone tissue engineering: physico-chemical, topographical, mechanical, degradation and biological properties. Advances in Polymer Sciences (2006) 200:209-231.

C. Aparicio, F.J. Gil, C. Fonseca, M. Barbosa, J.A. Planell. Corrosion Behaviour of Commercially Pure Titanium Shot Blasted with Different Materials and Sizes of Shot Particles for Dental Implant Applications Biomaterials (2003) 24(2):263-273.

E. Fernández, F.J. Gil, C. Aparicio, M. Nilsson, S. Sarda, D. Rodríguez, M.P. Ginebra, J.M. Manero, M. Navarro, J. Casals, J.A. Planell. Materials in Dental Implantology. In Dental Biomechanics; ed. A. Natali (2003) Taylor and Francis, London. ISBN 0-41-5306663. pp 69-89.

C. Aparicio, E. Engel, F.J. Gil, J.A. Planell. Human-osteoblast proliferation and differentiation on grit-blasted and bioactive titanium for dental applications. Journal of Materials Science Materials in Medicine (2002) 13:1105-1111.

M.P. Ginebra, L. Albuixech, E. Fernández-Barragán, C. Aparicio, F.J. Gil, J. San Román, B. Vázquez, J.A. Planell. Mechanical performance of acrylic bone cements containing different radiopacifying agents. Biomaterials (2002) 23(8):1873-1882.

M. Ontañón, C. Aparicio, M.P. Ginebra, J.A. Planell. Structure and Mechanical Properties of Bone. In Structural Biological Materials; ed. M. Elices (2000) Pergamon-Elsevier, New York. ISBN 0-08-0434169. pp. 31-72.

Collaborators

University of Minnesota School of Dentistry

  • Jorge Perdigao, Restorative Sciences
  • Brian Holmes, Restorative Sciences
  • Alex Fok, Restorative Sciences
  • Sven Gorr, Diagnostic and Biological Sciences
  • Joel Rudney, Diagnostic and Biological Sciences
  • Robert Jones, Developmental and Surgical Sciences
  • Thorsten Grunheid, Developmental and Surgical Sciences
  • Massimo Costalonga, Developmental and Surgical Sciences

Others

  • Gunjan Agarwal, The Ohio State University, OH
  • Mrinal Battacharya, University of Minnesota, MN
  • Joan Bechtold, University of Minnesota, MN
  • Maria-Giovanna Gandolfi, University of Bologna, Italy
  • Francisco-Javier Gil, Technological University of Catalonia, Spain
  • Maria-Pau Ginebra, Technological University of Catalonia, Spain
  • Henning Menzel, University of Braunschweig, Germany
  • Laurie Gower, University of Florida, CA
  • Alvaro Mata, Queen Mary College University of London, UK
  • Carlo Prati, University of Bologna, Italy Laurie Gower, University of Florida, FL
  • Jose Carlos Rodriguez-Cabello, University of Valladolid, Spain
  • Jianyong Wu, Shanghai Jiaotong University, Nanchang University, China

Teaching

Courses

Course Director

  • DDS 6411 – Applied Dental Biomaterials
  • DT 5410 – Applied Dental Biomaterials
  • OBIO 8027 - Biomaterials for Regenerative Medicine.
  • DENT 7411 - Dental Biomaterials in Prosthodontics

Other teaching assignments

  • OBIO 8030 - Physical Biology of the Oral Cavity (Invited lecturer)
  • BMEn 5001 – Advanced Biomaterials (Invited Lecturer)
  • DENT 8101 – Implantology (Invited Lecturer)