Conrado Aparicio, PhD, MSc Eng

Professor, Department of Restorative Sciences

Conrado Aparicio

Contact Info

apari003@umn.edu

Office Phone 612-625-4467

Fax 612-626-1484

Office Address:
16-250A Moos Tower
515 Delaware St. SE
Minneapolis, MN 55455

Additional Locations

Aparicio Lab

PhD, Technological Univ. Catalonia, Spain (Biomaterials), 2004

MScEng, Technological Univ. Catalonia, Spain (Materials Engineering), 1998

Post Doc, Northwestern University (Regenerative Medicine), 2007

Summary

Dr Conrado Aparicio is an investigator with a research focus on the surfaces of dental and orthopedic biomaterials, their design, modification, as well as the characterization and analysis of their physical, chemical, mechanical, and biological properties. He is a materials engineer by training and performed his PhD under the supervision of Professor Javier Gil at BarcelonaTech-UPC developing new surface treatments to improve osseointegration of dental implants.

After getting his position as a senior lecturer in Spain, Dr Aparicio moved to Chicago where he was a visiting scholar at the Institute for BioNanotechnology in Medicine of Northwestern University under the supervision of Professor Samuel Stupp. Dr Aparicio investigated the biomineralization of self-assembled nanostructured scaffolds made of peptide-amphiphiles.

Dr Aparicio’s main subjects of research are the understanding of the interactions between biological and synthetic materials, biofunctionalization of biological and synthetic surfaces with biomolecules for improving bioactivity and antimicrobial properties of different dental biomaterials, and biomineralization of biomaterials.

Recently, Dr Aparicio’s research interests have expanded to studying and developing new techniques and new biomaterials, including 1) dental restorative materials and biological agents to induce bone regeneration and teeth remineralization; 2) new materials and methodologies for the assessment, management, and improvement of esthetic dental restorations; 3) tissue engineering strategies to improve outcomes of transdermal devices and implants.

Dr Aparicio’s background and record of scholarly publications reflects a multi- and interdisciplinary approach to biomaterials and biomechanics science and engineering, including several biomolecular, in vitro and in vivo studies.

Awards & Recognition

  • 2018 Century Club Professor of the Year
  • International Guest Professor at Nanchang University, China
  • International Advisory Board of the Annual Conference of the European Society for Biomaterials
  • Visiting Professor at University of Bologna, Master’s Program in Endodontics and PhD Program in Dentistry
  • International Advisory Board of the 2015 World Bioceramics Conference
  • Beta Beta Chapter of Omicron Kappa Upsilon National Dental Honor Society, Honorary member
  • IRBM-Innovation and Research in Biomedical Engineering, Elsevier Journal, Associate Editor
  • University of Minnesota School of Dentistry Paper of the Year Award, 2013, 2014
  • DDS and DT Class of 2016 and 2014 Didactic Faculty Member of the Year (D2, DT2). School of Dentistry. University of Minnesota, 2013.
  • 9th World Biomaterials Congress, Rapid-Fire Poster Presentation Award
  • 3M Non-tenured Faculty Award
  • Best PhD Dissertation in Chemistry or Materials Science, 2004/2005
  • City of Barcelona Award for Technological Research, 2006
  • 2005 European Basic Research in Odontology Award
  • Journal of Materials Science: Materials in Medicine Best Paper Award, 2002

Professional Associations

  • IADR – International Association for Dental Research, Heraeus Travel Awards Committee, Subgroup Chair-Dental Materials: Biocompatibility
  • AADR – American Association for Dental Research, Fellowship Awards Committee, Subgroup Chair-Dental Materials: Biocompatibility
  • European Society for Biomaterials, Annual Meeting International Advisory Board
  • World Bioceramics Conference, Annual Meeting International Advisory Board
  • Society for Biomaterials, Member
  • Materials Research Society, Member
  • Dental Materials Academy, Member

Research

Research Summary/Interests

  • Bioinspired surface and interfaces for dental and orthopedic applications
  • Biomineralization of synthetic materials and tissues
  • Synthetic peptides, recombinant biopolymers, and self-assembly
  • Regeneration of hard tissues (enamel, dentin, bone)
  • Prevention and Control of Biofilms

Publications

Last 5 years

D.G. Moussa, A. Fok, C. Aparicio. Hydrophobic and Antimicrobial Dentin: A Peptide-based 2-tier Protective System for Dental Resin Composite Restorations. Acta Biomaterialia (2019) 88:251-265.

M. Tatullo, G. Spagnuolo, B. Codispoti, F. Zamparini, A. Zhang, C. Aparicio, C. Rengo, M. Nuzzolese, L. Manzoli, F. Fava, C. Prati, P. Fabbri, M.G. Gandolfi. PLA-based mineral-doped scaffolds seeded with human periapical cyst-derived MSCs: a promising tool for regenerative healing in dentistry. Materials (2019) 12(4): 597.

D.G. Moussa, C. Aparicio. Present and Future of Tissue Engineering Scaffolds for Dentin-Pulp Complex Regeneration. Journal of Tissue Engineering and Regnerative Medicine (2019) 13:58-75.

Z. Ye, X. Zhu, S. Acosta, D. Kumar, T. Sang, C. Aparicio. Self-assembly dynamics and Antimicrobial Activity of all L- and D-enantiomers of a Designer Peptide. Nanoscale (2019) 11: 266-275.

J. Gil, E. Ruperez, E. Velasco, C. Aparicio, J.M. Manero. Mechanism of fracture of NiTi superelastic endodontic rotary instruments. Journal of Materials Science: Materials in Medicine (2018) 29(8):131.

Y. Qi, Z. Ye, A. Fok, B.N. Holmes, M. Espanol, M.P. Ginebra, C. Aparicio. Effects of Molecular Weight and Concentration of Poly(Acrylic Acid) on Biomimetic Mineralization of Collagen. ACS Biomaterials Science and Engineering (2018) 4, 2758-2766.

V.P. Koidou, P.P. Argyris, E.P. Skoe, J. Mota Siqueira, X. Chen, L. Zhang, J.E. Hinrichs, M. Costalonga, C. Aparicio. Peptide Coatings to Improve Peri-implant Mucosal Seal. Biomaterials Science (2018) 6, 1936 – 1945.

P. Sevilla, A. Cirera, J. Dotor, F.J. Gil, C. Aparicio. In vitro cell response on Ti surfaces functionalized with TGF-?1 inhibitory peptides. Journal of Materials Science: Materials in Medicine (2018) 29(6) 73.

J.C. Matias de Souza, L. Bins-Ely, M.B. Sordi, R. de Souza Magini, C. Aparicio, T. Shokunfar, L. Cooper. Nanostructured surfaces of craniomaxilofacial and dental implants. In Nanostructured Biomaterials for Cranio-Maxillofacial and Oral Applications; eds. J. Souza, D. Hotza, B. Henriques, A.R. Boccaccini (2018) Elsevier. ISBN 9780128146217. pp.28

C. Larrucea, C. Aparicio, D. Olivares, C. Padilla E., A. Barrera, O. Lobos. Bacterial microleakage at the abutment-implant interface, In vitro study. Clinical Implant Dentistry and Related Research. (2018) 20:360–67.

M.G. Gandolfi; F. Zamparini; M. Degli Esposti; F. Chiellini; C. Aparicio; F. Fava; P. Fabbri; P. T.; C. Prati. Polylactic acid-based porous scaffolds doped with calcium silicate and dicalcium phosphate dihydrate designed for biomedical application. Materials Science and Engineering C (2018) 82:163-81.

C.A. Carrera, Y. Li, R. Chen, C. Aparicio, A. Fok, J. Rudney. Interfacial Degradation Of Adhesive Composite Restorations Mediated By Oral Biofilms And Mechanical Challenge In An Extracted Tooth Model Of Secondary Caries. Journal of Dentistry (2017) 66:62-70.

P. Sevilla, F.J. Gil, C. Aparicio. Relevant properties for immobilizing short peptides on biosurfaces. IRBM (2017) 28(5):256-65.

N. Harmouche, C. Aisenbrey, F. Porcelli, Y. Xia, S.E.D. Nelson, X. Chen, J. Raya, L. Vermeer, C. Aparicio, G. Veglia, S.-U. Gorr, B. Bechinger. Solution and solid-state NMR structural investigations of the antimicrobial designer peptide GL13K in membranes. Biochemistry (2017) 56:4269-78.

M. Mattotti, Z. Alvarez, L. Delgado, M.A. Mateos-Timoneda, C. Aparicio, J.A. Planell, S. Alcántara, E. Engel. Differential neuronal and glial behavior on flat and micro patterned chitosan films. Colloids and Surfaces B: Biointerfaces (2017) 158:569-77.

X. Chen, X.C. Zhou, S. Liu, L.F. Wu, C. Aparicio, J.Y. Wu. In vivo osseointegration of dental implants with an antimicrobial peptide coating. Journal of Materials Science: Materials in Medicine (2017) 28:76.

J. Prasad-Govindarahjulu, X. Chen, Y. Li, J.C. Rodriguez-Cabello, M. Battacharya, C. Aparicio. Chitosan-recombinamer layer-by-layer coatings for multifunctional implants. International Journal of Molecular Sciences (2017) 18:369.

Y. Li, J.C. Rodriguez-Cabello, C. Aparicio. Intrafibrilar Mineralization of Self-Assembled Elastin-Like Recombinamer Fibrils. ACS Applied Materials and Interfaces (2017) 9(7):5838–46.

J. F. Diaz-Quiroz, Y. Li, C. Aparicio and K. Echeverri. Development of a 3D matrix for modeling mammalian spinal cord injury in vitro. Neural Regeneration Research (2016) 11(11): 1810-15.

C. Caparros, M. Ortiz-Hernandez, M. Molmeneu, M. Punset, J.A. Calero, C. Aparicio, F.J. Gil. Bioactive macroporous titanium implants highly interconnected. Journal of Materials Science-Materials in Medicine (2016) 27:151-62.

C.A. Carrera, Y.C. Chen, Y. Li, J. Rudney, C. Aparicio, A. Fok. Dentin-Composite Bond Strength Measurements Using the Brazilian Disk Test. Journal of Dentistry (2016) 52:37-44.

G. Kotsakis, C. Lan, J. Barbosa, K. Lill, R. Chen, J. Rudney, C. Aparicio. Antimicrobial agents used in the treatment of peri-implantitis alter the physicochemistry and cytocompatibility of titanium surfaces. Journal of Periodontology (2016) 87:809-819.

P. Sevilla, K.V. Holmberg, J. Dotor, D. Rodriguez, F.J. Gil, C. Aparicio. Surface immobilization and bioactivity of TGF-?1 inhibitor peptides for bone implant applications. Journal of Biomedical Materials Research B: Applied Biomaterials (2016) 104B: 385-394.

Biomineralization and Biomaterials. Fundamentals and Applications. Eds, C. Aparicio, M.P. Ginebra. Woodhead Publishing. Inc. – Elsevier (2015). ISBN: 978-1-78242-338-6.

Y. Li, X. Chen, A. Fok, J.C. Rodriguez-Cabello, C. Aparicio. Biomimetic Mineralization of Recombinamer-Based Hydrogels toward Control Morphologies and High Mineral Density. ACS Applied Materials and Interfaces (2015) 7(46):25784–25792.

E. Fernandez-Garcia, X. Chen, C.F. Gutierrez-Gonzalez, A. Fernandez, S. Lopez-Esteban, C. Aparicio. Peptide-functionalized Zirconia and New Zirconia/Titanium Biocermets for Dental Applications. The Journal of Dentistry (2015) 43(9):1162-1174.

K. Riccardi, J.M. Manero, Y. Li, C. Aparicio, F.J. Gil, E. Ruperez. Development of a tantalum scaffold for orthopaedic applications produced by space-holder method. Materials & Design (2015) 83: 112-119.

Y. Li, C. Carrera, R. Chen, J. Li, Y. Chen, P. Lenton, J.D. Rudney, R.S. Jones, C. Aparicio, A. Fok. Fatigue failure of dentin-composite disks subjected to cyclic diametral compression. Dental Materials (2015) 31(7):778-788.

C.A. Carrera, C. Lan, D. Escobar-Sanabria, Y. Li, J. Rudney, C. Aparicio, A. Fok. The Use of Micro-CT with Image Segmentation to Quantify Leakage in Dental Restorations. Dental Materials (2015) 31(4):382-390.

X. Chen, H. Hirt, Y. Li, S.-U. Gorr, C. Aparicio. Antimicrobial GL13K peptide coatings killed and ruptured the wall of Streptococcus gordonii and prevented formation and growth of biofilms. PLOS ONE (2014). 9(11):e11579.

N. Marín-Pareja, E. Salvagni, J. Guillem-Marti, C. Aparicio, M.P. Ginebra. Collagen-functionalized titanium surfaces for biological sealing of dental implants: Effect of immobilization process on fibroblasts response. Colloids and Surfaces B: Biointerfaces (2014) 122:601-610.

Y. Li, X. Chen, A. Ribeiro, E. Jensen, K.H. Holmberg. J.C. Rodriguez-Cabello, C. Aparicio. Hybrid nanotopographic surfaces obtained by biomimetic mineralization of statherin-inspired elastin-like recombinamers. Advanced Healthcare Materials (2014) 3:1638-1647.

E. Salvagni, G.Y. Berguig, E. Engel, J.C. Rodriguez-Cabello, G. Coullerez, M. Textor, F.J. Gil, J.A. Planell, C. Aparicio. A bioactive elastin-like recombinamer reduces unspecific protein adsorption and enhances cell response on titanium surfaces. Colloids and Surfaces B: Biointerfaces (2014) 114: 225-233.

Y. Li, C. Carrera, R. Chen, J. Li, P. Lenton, J.D. Rudney, R.S. Jones, C. Aparicio, A. Fok. Interfacial Degradation in Composite Restorations Subjected to Multi-Species Biofilm Challenges. Acta Biomaterialia (2014) 10:375-383.

D. Isfeld, C. Aparicio, R.S. Jones. Assessing near Infrared Optical Properties of Ceramic Orthodontic Brackets using Cross-Polarization Optical Coherence Tomography. Journal of Biomedical Materials Research B (2014) 102:516-523.

F.J. Gil, N. Manzanares, A. Badet, C. Aparicio, M.P. Ginebra. Biomimetic Treatment of Dental Implants for Short-Term Bone Regeneration. Clinical Oral Investigations (2014) 18:59-66.

Other relevant publications

Y. Li, C. Aparicio. Visualizing the subfibrillar structure of mineralized collagen fibrils: A model of the ultrastructure of bone. PLoS ONE (2013) 8(9): e76782.

K.V. Holmberg, M. Abdolhosseini, X. Chen, E. Jensen, Y. Li, S.-U. Gorr, C. Aparicio. Bio-inspired Antimicrobial Peptide Coating for Dental Implants. Acta Biomaterialia (2013) 9(9): 8224-31.

X. Chen, P. Sevilla, C. Aparicio.Surface biofunctionalization by covalent co-immobilization of oligopeptides. Colloids and Surfaces B: Biointerfaces. (2013) 107:189-97.

X. Chen, Y. Li, C. Aparicio. Biofunctional Coatings for Dental Implants. In Thin Films and Coatings in Biology. Biological and Medical Physics -Biomedical Engineering Series; ed. S. Nazarpour (2013) Springer-Verlag. ISBN 978-94-007-2592-8. pp 105-143.

M. Pegueroles, Ch. Tonda, E. Engel, J.A. Planell, C. Aparicio.Adsorption of fibronectin, fibrinogen, and albumin on TiO2: time-resolved kinetics, structural changes, and competition study.Biointerphases (2012) 7:48.

T. Sargeant, C. Aparicio, J. Goldberger, H. Cui, S.I. Stupp.Mineralization of Peptide Amphiphiles Nanofibers and its Effect on Differentiation of Human Mesenchymal Stem Cells.Acta Biomaterialia (2012) 8(7):2456-2465.

Y. Li, T.T. Thula, S. Jee, S.L. Perkins, C. Aparicio, E.P. Douglas, L.B. Gower. Biomimetic Mineralization of Woven Bone-Like Nanocomposites: Role of Collagen Cross-Links. Biomacromolecules (2012) 13:49-59.

C. Aparicio, A. Padros, F.J. Gil.In vivo evaluation of Micro-Rough and Bioactive Titanium Dental Implants using Histometry and Pull-Out Tests. Journal of the Mechanical Behavior of Biomedical Materials (2011) 4:1672-1682.

S. Zhang, M. Greenfield, A. Mata, L. Palmer, R, Bitton, J.R. Mantei, C. Aparicio, M. Olvera, S.I. Stupp. A Self-Assembling Pathway to Aligned Monodomain Gels. Nature Materials (2010) 9:595-601.

A. Mata, Y. Biao, K. Henrikson, C. Aparicio, R. Satcher, S .Stock, S.I. Stupp. Bone regeneration mediated by biomimetic mineralization of a nanofiber matrix. Biomaterials (2010) 31:6004-6012.

M. Pegueroles, C. Aparicio, M. Bosio, E. Engel, F.J. Gil, J.A. Planell, G. Altankov.Spatial Organization of Osteoblast Fibronectin-Matrix on Titanium Surface – Effects ofRoughness, Chemical Heterogeneity, and Surface Free Energy. Acta Biomaterialia (2010) 6, 291-301.

M. Pegueroles, C. Aparicio, M. Bosio, E. Engel, F.J. Gil, J.A. Planell, G. Altankov.Spatial Organization of Osteoblast Fibronectin-Matrix on Titanium Surface – Effects ofRoughness, Chemical Heterogeneity, and Surface Free Energy. Acta Biomaterialia (2010) 6, 291-301.

E. Engel, S. Del Valle,C. Aparicio, G. Altankov, L. Asin, J.A. Planell. M.P. Ginebra Topography mediated ion exchanged modulates osteoblast behaviour in bioactive materials. CPC as a model substrate. Tissue Engineering (2008) 14:1341-1351.

A. Mata,L. Hsu, R. Capito,C. Aparicio,K. Henrikson, S.I. Stupp. Micro-patterning of Bioactive Self-Assembling Gels. (2009) Soft Matter 5:1228–1236.

E. Engel, S. Del Valle, C. Aparicio, G. Altankov, L. Asin, J.A. Planell, M.P. Ginebra Topography mediated ion exchanged modulates osteoblast behaviour in bioactive materials. CPC as a model substrate. Tissue Engineering (2008) 14:1341-1351.

C. Aparicio, J.M. Manero, F. Conde, M. Pegueroles, J.A. Planell, M. Vallet-Regí, F.J. Gil. Acceleration of apatite nucleation on microrough bioactive titanium for bone-replacing implants. Journal of Biomedical Materials Research Part A (2007) 82A:521-529.

A. Michiardi, C. Aparicio, B. Ratner, J.A. Planell, F.J. Gil.The influence of surface energy on competitive protein adsorption on oxidized NiTi surfaces.Biomaterials (2007) 28: 586-594.

F.J. Gil, J.A. Planell, A. Padrós, C. Aparicio. Effect of shot-blasting and heat treatment on fatigue fracture of titanium dental implants. Dental Materials (2007) 23: 486-491.

A. Michiardi, C. Aparicio, J.A. Planell, F.J. Gil. New oxidation treatment of NiTi shape memory alloys to obtain Ni-free surfaces and improve biocompatibility. Journal of Biomedical Materials Research Part B: Applied Biomaterials (2006) 77B:249-256.

M. Navarro, C. Aparicio, M. Charles-Harris, M.P. Ginebra, E.Engel, J.A. Planell. Development of a biodegradable composite scaffold for bone tissue engineering: physico-chemical, topographical, mechanical, degradation and biological properties. Advances in Polymer Sciences (2006) 200:209-231.

C. Aparicio, F.J. Gil, C. Fonseca, M. Barbosa, J.A. Planell. Corrosion Behaviour of Commercially Pure Titanium Shot Blasted with Different Materials and Sizes of Shot Particles for Dental Implant Applications. Biomaterials (2003) 24(2):263-273.

E. Fernández, F.J. Gil, C. Aparicio, M. Nilsson, S. Sarda, D. Rodríguez, M.P. Ginebra, J.M. Manero, M. Navarro, J. Casals, J.A. Planell. Materials in Dental Implantology. In Dental Biomechanics; ed. A. Natali (2003) Taylor and Francis, London. ISBN 0-41-5306663. pp 69-89.

C. Aparicio, E. Engel, F.J. Gil, J.A. Planell. Human-osteoblast proliferation and differentiation on grit-blasted and bioactive titanium for dental applications. Journal of Materials Science Materials in Medicine (2002) 13:1105-1111.

M.P. Ginebra, L. Albuixech, E. Fernández-Barragán, C. Aparicio, F.J. Gil, J. San Román, B. Vázquez, J.A. Planell. Mechanical performance of acrylic bone cements containing different radiopacifying agents. Biomaterials (2002) 23(8):1873-1882.

M. Ontañón, C. Aparicio, M.P. Ginebra, J.A. Planell.Structure and Mechanical Properties of Bone. In Structural Biological Materials; ed. M. Elices (2000) Pergamon-Elsevier, New York. ISBN 0-08-0434169. pp. 31-72.

Collaborators

University of Minnesota School of Dentistry

Massimo Costalonga, Developmental and Surgical Sciences

Alex Fok, Restorative Sciences

Sven Gorr, Diagnostic and Biological Sciences

Brian Holmes, Restorative Sciences

Robert Jones, Developmental and Surgical Sciences

Jorge Perdigao, Restorative Sciences

Joel Rudney, Diagnostic and Biological Sciences

Others

Gunjan Agarwal, The Ohio State University, Columbus, OH

Mrinal Battacharya, University of Minnesota, MN

Joan Bechtold, University of Minnesota, MN

Maria-Giovanna Gandolfi, University of Bologna, Italy

Francisco-Javier Gil, Technological University of Catalonia, Spain

Maria-Pau Ginebra, Technological University of Catalonia, Spain

Henning Menzel, University of Braunschweig, Germany

Laurie Gower, University of Florida, Gainsville, FL

Alvaro Mata, Queen Mary College University of London, UK

Carlo Prati, University of Bologna, Italy Laurie Gower, University of Florida, FL

Jose Carlos Rodriguez-Cabello, University of Valladolid, Spain

Jianyong Wu, Shanghai Jiaotong University, Nanchang University, China

Hongli Zhu, Northeastern University, Boston, MA

Teaching

Courses

Course Director

  • DDS 6411 – Biomaterials Science I
  • DDS6412 – Biomaterials Science II
  • DT 5410 – Biomaterials Science
  • OBIO 8027 - Biomaterials for Regenerative Dentistry

Other teaching assignments

  • BMEn 5001 – Advanced Biomaterials (Invited Lecturer)
  • DENT 8101 – Implantology (Invited Lecturer)