Sven-Ulrik Gorr, PhD

Interim Associate Dean for Academic Affairs, School of Dentistry

Sven-Ulrik Gorr

Contact Info

sugorr@umn.edu

Office Phone 612-626-5728

Fax 612-625-6948

Office Address:
18-154/146A Moos Tower
515 Delaware St. SE
Minneapolis, MN 55455

PhD, University of Copenhagen (Biochemistry), 1990

Cand. Scient (MSc) Biochemistry, University of Copenhagen, Denmark, 1984

Research

Research Summary/Interests

The Gorr laboratory develops antimicrobial peptides with activity against drug-resistant Gram negative and Gram positive bacteria and their biofilms. Current projects are focused on understanding bacterial resistance mechanisms and determine how some antimicrobial peptides can overcome these mechanisms while bacteria are resistant to closely related peptides. These insights inform translational work, which is focused in bringing improved and well-characterized antimicrobial peptides to the clinic. Apart from the PI, the laboratory employs no full-time staff. Using lean principles, we find efficiencies in employing technical specialists and collaborating with leaders in their field to venture into basic microbiology, structural biology and drug development.

Publications

  • Hirt H, Hall JW, Larson E, Gorr SU. 2018. A D-enantiomer of the antimicrobial peptide GL13K evades antimicrobial resistance in the Gram positive bacteria Enterococcus faecalis and Streptococcus gordonii. PLoS One 13:e0194900.
  • Gorr SU. 2018. Synthetic peptides and peptide mimetics - U.S. patent 9,914,750.
  • Harmouche N, Aisenbrey C, Porcelli F, Xia Y, Nelson SED, Chen X, Raya J, Vermeer L, Aparicio C, Veglia G, Gorr SU, Bechinger B. Solution and Solid-State Nuclear Magnetic Resonance Structural Investigations of the Antimicrobial Designer Peptide GL13K in Membranes. Biochemistry. 56(32):4269-4278 (2017). PMID: 28699734
  • Bechinger B, Gorr SU. Antimicrobial Peptides: Mechanisms of Action and Resistance. J Dent Res. 96(3):254-260 (2017). PMID:27872334
  • Chen X, Hirt H, Li Y, Gorr SU, Aparicio C. Antimicrobial GL13K peptide coatings killed and ruptured the wall of Streptococcus gordonii and prevented formation and growth of biofilms. PLoS One. 9(11):e111579 (2014). PMID:25372402
  • Hirt H, Gorr SU. Antimicrobial peptide GL13K is effective in reducing biofilms of Pseudomonas aeruginosa. Antimicrob Agents Chemother. 57(10):4903-4910 (2013). PMID:23917321
  • Balhara V, Schmidt R, Gorr SU, Dewolf C. Membrane selectivity and biophysical studies of the antimicrobial peptide GL13K. Biochim Biophys Acta. 1828(9):2193-203. (2013) PMID:2374736
  • Holmberg KV, Abdolhosseini M, Li Y, Chen X, Gorr SU, Aparicio C. Bio-inspired stable antimicrobial peptide coatings for dental applications. Acta Biomater. 9:8224-8231 (2013). PMID:23791670
  • Mestres G, Abdolhosseinin M, Bowles W, Huang SH, Aparicio C, Gorr SU, Ginebra MP. Antimicrobial properties and dentin bonding strength of magnesium phosphate cements. Acta Biomaterialia, 9:8384-8393 (2013). PMID:23747324
  • Horvath S, Nazmul-Hossain AN, Pollard RP, Kroese FG, Vissink A, Kallenberg CG, Spijkervet FK, Bootsma H, Michie SA,Gorr SU, Peck AB, Cai C, Zhou H, Wong DT. Systems analysis of primary Sjögren's syndrome pathogenesis in salivary glands identifies shared pathways in human and a mouse model. Arthritis Res Ther. 14:R238 (2012) . PMID: 23116360
  • Gorr S-U, Wennblom TJ, Horvath S, Wong DTW, Michie SA. Text-mining applied to autoimmune disease research: The Sjogren's Syndrome Knowledge Base. BMC Musculoskeletal Disorders, 13:119 (2012). PMID:22759918
  • Abdolhosseini M, Nandula SR, Song J, Hirt H, Gorr SU. Lysine substitutions convert a bacterial-agglutinating peptide into a bactericidal peptide that retains anti-lipopolysaccharide activity and low hemolytic activity. Peptides. 35:231-238 (2012). PMID:2248428
  • Abdolhosseini M, Sotsky JB, Shelar AP, Joyce PB, Gorr SU. Human parotid secretory protein is a lipopolysaccharide-binding protein: identification of an anti-inflammatory peptide domain. Mol Cell Biochem. 359:1-8 (2012). PMID:21833535
  • Gorr S-U. Antimicrobial peptides in periodontal innate defense, Frontiers in Bioscience, 15: 84-98 (2012). PMID:22142958
  • Biswas S, Knipp RJ, Gordon LE, Nandula SR, Gorr SU, Clark GJ, Nantz MH Hydrophobic Oxime Ethers: A Versatile Class of pDNA and siRNA Transfection Lipids. ChemMedChem. 6: 2063-2069 (2011). PMID:21882348
  • Gorr S-U., Abdolhosseini M., Shelar A., Sotsky, J., Dual host-defence functions of SPLUNC2/PSP and synthetic peptides derived from the protein. Biochemical Society Transactions, 39(4): 1028-1032 (2011). PMID:21787342
  • Gorr S-U, Abdolhosseini M. Antimicrobial peptides and periodontal disease. Journal of Clinical Periodontology, 38 (suppl. 11): 126-141 (2011). PMID:21323710
  • Gorr S-U. Antimicrobial peptides of the oral cavity. Periodontology 2000. 51:152-180 (2009). PMID:19878474
  • Hu S, Zhou M, Jiang J, Wang J, Elashoff D, Gorr S, Michie SA, Spikervet FKL, Bootsma H, Kallenberg CGM, Vissink A, Horvath S, Wong DT. Systems Analysis of Sjögren’s Syndrome and MALT Lymphoma Development in Parotid Glands.Arthritis and Rheumatism, 60:81-92 (2009) PMCID: PMC2718690
  • Gorr S-U, Sotsky JB, Shelar AP, Demuth DR. Design of bacteria-agglutinating peptides derived from Parotid Secretory Protein, a member of the Bactericidal/Permeability Increasing-like protein family. Peptides, 29:2118-2127 (2008) PMID:18952131
  • Kinane, D. F. Galicia, J. Gorr, S. U. Stathopoulou, P. Benakanakere, M. M. P. gingivalis interactions with epithelial cells.Front. Biosci. 13: 966-984 (2008).
  • Fasciotto BH, Kuehn U, Cohn DV, Gorr S-U. Secretory cargo composition affects polarized secretion in MDCK epithelial cells. Mol. Cell. Biochem. 310:67-75 (2008)