Ioannis G. Koutlas, DDS, MS

Associate Professor, Director of Oral Pathology Laboratories, Department of Diagnostic and Biological Sciences

Ioannis G. Koutlas

Contact Info

koutl001@umn.edu

Office Phone 612-624-8607

Fax 612-626-3076

Mailing Address:
16-116B Moos Tower
515 Delaware St. SE
Minneapolis, MN 55455

Associate Professor, Director of Oral Pathology Laboratories, Department of Diagnostic and Biological Sciences

Division of Oral and Maxillofacial Pathology


MS, University of Minnesota School of Dentistry, 1993

DDS, University of Athens Faculty of Dentistry, 1989

Summary

Awards & Recognition

  • American Association of Oral and Maxillofacial Surgery, Best Poster Award, 2010
  • Inventor Recognition Award (commercial license awardees), University of Minnesota, 2005
  • Instructor of the Year (Class of 2007), 2005
  • Best Paper Award, The American Society of Mechanical Engineers, 2002
  • Omicron Kappa Upsilon, Beta Beta Chapter, 1997

Professional Associations

Professional Associations

  • American Academy of Oral and Maxillofacial Pathology Fellow: 1993-present
  • British Society of Oral and Maxillofacial Pathology Member: 2016-present
  • Minnesota Society of Pathologists Member 1991-present
  • North American Society of Head and Neck Pathology: Life member

Leadership Roles

  • College of American Pathologists: Laboratory Accreditation Leader
  • American Academy of Oral and Maxillofacial Pathology, Councilor, 3-year term (2015)
  • American Academy of Oral and Maxillofacial Pathology, Long Range Planning Committee (2010-2013)
  • American Academy of Oral and Maxillofacial Pathology, Fellowship Committee (2006-2010, served as chair in 2010)
  • American Academy of Oral and Maxillofacial Pathology, Laboratory Service Committee (2001-2004, served as chair in 2004)

Research

Research Summary/Interests

Syndromes of the head and neck; Molecular signatures of tumors of the head and neck

Publications

  • IG Koutlas, J Jessurun, A Iamaroon. Immunohistochemical evaluation and in situ hybridization in a case of inverted ductal papilloma. J Oral Maxillofac Surg 1994;52:503-6
  • IG Koutlas, J Jessurun. Arteriovenous hemangioma. A histochemical and immunohistochemical study. J Cutan Pathol1994;21:343-9
  • KI Tosios, IG Koutlas, SI Papanicolaou. Intravascular papillary endothelial hyperplasia of the oral soft tissues. Report of 18 cases and review of the literature. J Oral Maxillofac Surg 1994;52:1263-8
  • KI Tosios, IG Koutlas, SI Papanicolaou, N Kapranos. Spindle cell hemangioendothelioma of the oral cavity. Report of a case. J Oral Pathol Med 1995;24:379-82
  • HO Sedano, R Carlos, IG Koutlas. Respiratory scleroma. A clinicopathologic and ultrastructural study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996;81:665-71
  • IG Koutlas, JC Manivel. Epithelioid leiomyoma of the oral mucosa. Oral Surg Oral Med Oral Pathol Oral Radiol Endod1996;82:670-73
  • RJ Gorlin, IG Koutlas. Multiple schwannomas, multiple nevi and multiple vaginal leiomyomas - a new dominant syndrome. Am J Med Genet 1998;78:76-81
  • AK Roche, IG Koutlas, KC Kajender. Labeling of calcitonin gene-related peptide and substance P increases in subnucleus caudalis of rabbit during maxillary sinusitis. Brain Res 1998;791:283-289
  • B Perez-Ordonez, IG Koutlas, E. Stich, RW Gilbert, RCK Jordan. Solitary fibrous tumor of the oral cavity. An uncommon location for a ubiquitous neoplasm. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;87:589-593
  • EL Aronovich, KP Carmichael, H Morizono, IG Koutlas, M Deanching, G Hoganson, A Fischer, CB Whitley. Canine Heparan Sulfate Sulfamidase and the Molecular Pathology Underlying Sanfilippo Syndrome Type A in Dachshunds.Genomics 2000;68:80-84
  • IG Koutlas, RB Gillum, MW Harris, BA Brown. Surgical (implantation) cyst of the mandible with ciliated respiratory epithelial lining. A case report. J Oral Maxillofac Surg 2002;60:324-325
  • BT Larson, AG Erdman, NV Tsekos, E Yakoub, PV Tsekos, IG Koutlas. Design of an MRI-compatible robotic stereotactic device for minimally invasive interventions in the breast. J Biomech Eng 2004;126:458-65
  • Koutlas IG, Pambuccian SE, Jessurun J, Manivel JC, Gopalakrishnan R. Perivascular epithelioid cell tumor of the oral cavity. Arch Pathol Lab Med 2005;129:690-693
  • Koutlas IG, Dace B. Multifocal intraoral acquired lymphangiectases (lymphangiomas) following surgical and radiation treatment for oral squamous cell carcinoma. J Oral Maxillofac Surg 2006;64:528-530
  • Gopalakrishnan R, Simonton S, Rohrer MD, Koutlas IG. Cystic variant of calcifying epithelial odontogenic tumor. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;102:773-777
  • Tosios KI, Gouveris I, Sklavounou A, Koutlas IG. Spindle cell hemangioma of the head and neck: Case report of an unusual (or under-diagnosed) tumor. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;105:216-221
  • Berg JC, Scheithauer BW, Spinner RJ, Allen CM, Koutlas IG. Plexiform schwannoma: A clinicopathologic overview with emphasis upon the head and neck region. Human Pathol 2008;39:633-640
  • Roqueber D, Champsaur A, Gil del Real P, Prasad H, Rohrer MD, Pintado M, Hao Y, Koutlas IG. Amelogenesis imperfecta, rough hypoplastic type, dental follicular hamartomas and gingival hyperplasia. Report of a case from Central America and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;106:92-98
  • Tosios KI, Gopalakrishnan R, Koutlas IG. So-called hybrid central odontogenic fibroma/central giant cell lesion of the jaws. A report on seven additional cases, including an example in a patient with cherubism, and hypotheses on the pathogenesis. Head Neck Pathol 2008;2:333-338
  • Koutlas IG, Allen CM, Warnock GR, Manivel JC. Sclerosing odontogenic carcinoma. A previously unreported variant of a locally aggressive odontogenic neoplasm with no apparent metastatic potential. Am J Surg Pathol 2008;32:1613-1619
  • Koutlas IG, Koch CA, Vickers RA, Brouwers F, Vortmeyer AO. An unusual ostensible example of oral basal cell carcinoma. J Cutan Pathol 2009;36:464–470
  • Gopalakrishnan R, Koutlas IG, Schauer GM, Schnitker G. Dental (odontogenic) choristoma of the tongue. J Oral Maxillofac Surg 2009;67:1135-1138 Piperi E, Omlie JE, Pambuccian SE, Koutlas IG. Oral hairy leukoplakia in HIV-negative patients. Report of 10 cases. Int J Surg Pathol 2010;18:177-83
  • Piperi E, Rohrer MD, Pambuccian SE, Koutlas IG. Vascular solitary fibrous tumor with “floret” cells or giant cell angiofibroma? A lingual example highlighting the overlapping characteristics of these entities and positive immunoreaction for estrogen and progesterone receptors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod2009;107:685-690
  • Koutlas IG, Scheithauer BW. Palisaded encapsulated (“solitary circumscribed”) neuroma of the oral cavity. A review of 56 cases. Head Neck Pathol 2010;4:15-26
  • Houpis CH, Tosios KI, Papavasileiou D, Christopoulos PG, Koutlas IG, Sklavounou A, Alexandrides C. Parathyroid hormone related peptide (PTHrP), parathyroid hormone/parathyroid hormone related peptide receptor 1 (PTHR1), and MSX1 protein are expressed in central and peripheral giant cell granulomas of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;109:415-424
  • Tosios KI, Economou I, Vasilopoulos NN, Koutlas IG. Elastofibromatous changes and hyperelastosis of the oral mucosa. Head Neck Pathol 2010;4:31-36
  • Piperi EP, Rake SA, Tosios KI, Vasilopoulou EE, Rake AP, Sandler NA, Issacson T, Sklavounou A, Koutlas IG. Mandibular melanotic neuroectodermal tumor of infancy treated conservatively with enucleation. A case report with 11 years follow-up and review of the literature. J Craniofac Surg 2010;21:685-688
  • Koutlas IG, Scheithauer BW, Folpe AL. Intraoral perineuriomas, soft tissue type. Report of the five cases and review of the literature. Head Neck Pathol 2010;4;113-120
  • Tosios KI, Koutlas IG, Kyriakopoulos VF, Balta M, Theologie-Lygidakis N, Vardas E, Iatrou I. Time to abandon the term angiomyolipoma for non-PEComatous angiomyomatous (or angiomatous) oral tumors with adipocytes. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;110:492-497
  • Omlie JE, Koutlas IG. Acinic cell carcinoma of minor salivary glands. A clinicopathologic study of 21 cases. J Oral Maxillofac Surg 2010;68:2053-2057
  • Prodromidis GI, Tosios KI, Koutlas IG. Cemento-osseous dysplasia-like lesion and complex odontoma associated with an impacted third molar. Head Neck Pathol 2011;5:401-404
  • Piperi E, Tosios KI, Nikitakis NG, Kyriakopoulos VF, Tzerbos F, Koutlas IG, Sklavounou A. Well-differentiated liposarcoma/atypical lipomatous tumor of the oral cavity: Report of three cases and review of the literature. Head Neck Pathol 2012;63:354-63
  • Pambuccian SE, Stelow EB, Koutlas IG, Thrall MJ. Head and neck pathology: new developments in the diagnosis and pathogenesis of head and neck tumors. Editorial Patholog Res Int 2012; Epub 2012
  • Tosios KI, Prountzos N, Katsoulas N, Koutlas IG, Sklavounou-Andrikopoulou A. Melan-A/Mart-1- or HMB-45-positive melanocytes are not present in calcifying cystic odontogenic tumors (calcifying odontogenic cysts): a study in 13 Caucasian patients. J Oral Sci 2012;54:33-8
  • Argyris PP, Pambuccian SE, Cayci Z, Singh C, Tosios KI, Koutlas IG. Lacrimal gland adenoid cystic carcinoma with high-grade transformation to myoepithelial carcinoma: Report of a case and review of literature. Head Neck Pathol2013;7:85-9
  • Argyris PP, Reed RC, Manivel JC, Lopez-Terrada D, Jakacky J, Cayci Z, Tosios KI, Pambuccian SE, Thompson LD,Koutlas IG. Oral Alveolar Soft Part Sarcoma in Childhood and Adolescence: Report of Two Cases and Review of Literature. Head Neck Pathol 2013;7:40-9
  • Reiland MD, Koutlas IG, Gopalakrishnan R, Pearson AG, Basi DL. Metastasizing pleomorphic adenoma presents intraorally: a case report and review of the literature. J Oral Maxillofac Surg 2012;70:e531-40.
  • Koutlas IG, Forsman C, Kyrkanides S, Oetting W, Petryk A. Autosomal dominant mesomandibular fibro-osseous dysplasia. An apparently self-resolving inherited fibro-osseous lesion of the jaws. Front Physiol 2012;3:458
  • Karathanasi V, Tosios KI, Nikitakis NG, Piperi E, Koutlas IG, Trimis G, Sklavounou A. TGF-?1, Smad-2/-3, Smad-1/-5/-8, and Smad-4 signaling factors are expressed in ameloblastomas, adenomatoid odontogenic tumors, and calcifying cystic odontogenic tumors: an immunohistochemical study. J Oral Pathol Med 2013;42:415-23
  • Argyris PP, Kademani D, Pambuccian SE, Nguyen R, Tosios KI, Koutlas IG. Comparison between p16INK4A Immunohistochemistry and Human Papillomavirus Polymerase Chain Reaction Assay in Oral Papillary Squamous Cell Carcinoma (OPSCCa) J Oral Maxillofac Surg 2013; 71:1676-8
  • Koutlas IG, Scheithauer BW. On Pseudo-Onion Bulb Intraneural Proliferations of the Non-Major Nerves of the Oral Mucosa Head Neck Pathol 2013;7:334-43
  • Argyris PP, Dolan M, Piperi E, Tosios KI, Pambuccian SE, Koutlas IG. Oral follicular lymphomas. A short report of 8 cases with assessment of the IGH/BCL2 gene fusion with fluorescence in situ hybridization. Oral Surg Oral Med Oral Pathol Oral Radiol 2013;116:343-7
  • Urias Barreras CM, Quezada Rivera D, Koutlas IG, Gaitán Cepeda LA. Clear cell cystic variant of calcifying epithelial odontogenic tumor. Head Neck Pathol 2013; epub ahead of print October 1, 2013
  • Argyris PP, Koutlas IG. Oral fibroma with HPV-associated epithelial dysplasia: Even in fibromas you should expect the unexpected. Int J Surg Pathol 2013; epub ahead of print November 14, 2013
  • Argyris PP, Gopalakrishnan R, Pambuccian SE, Tosios KI, Koutlas IG. Polymorphous low-grade adenocarcinoma of the upper lip with metachronous myoepithelioma of the buccal mucosa. Oral Surg Oral Med Oral Pathol Oral Radiol 2013; epub ahead of print November 20, 2013
  • Piperi EP, Tosios KI, Sklavounou A, Stich E, Koutlas IG. Junctional Spitz tumor (Nevus) of the upper lip. Head Neck Pathol 2013; epub ahead of print November 29, 2013
  • Pingel K, Kalogirou EM, Koutlas IG, Tosios KI. [Mandibular metastasis of a papillary thyroid carcinoma, tall cell variant. Case report and review of the literature.] Hell Arch Oral Maxillofac Surg 2013;14:143-52
  • Katsoulas N, Tosios KI, Argyris P, Koutlas IG, Sklavounou A. Lymphangioma circumscriptum, angiokeratoma, or superficial vascular ectasia with epithelial hyperplasia? Oral Surg Oral Med Oral Pathol Oral Radiol 2013; epub ahead of print December 6, 2013
  • Ceballos Sáenz C, Argyris PP, Manivel JC, Urias Barreras CM, Koutlas IG. Nasopharyngeal Hyalinizing Clear Cell Carcinoma: Report of the Histopathologic Features of a Case Showing EWSR1 Rearrangements by FISH and Literature Review. Int J Surg Pathol 2014; epub ahead of print March 11, 2014
  • Argyris PP1, Nelson AC, Papanakou S, Merkourea S, Tosios KI, Koutlas IG. Localized juvenile spongiotic gingival hyperplasia featuring unusual p16INK4A labeling and negative human papillomavirus status by polymerase chain reaction. J Oral Pathol Med 2015;44:37-44
  • Argyris PP, Wehrs RN, García JJ, Koutlas IG. Fluorescence in situ hybridization identifies Mastermind-like 2 (MAML2) rearrangement in odontogenic cysts with mucous prosoplasia. A pilot study. Histopathol 2015;66:791-797
  • Argyris PP, Koutlas IG, Cooley S, Yohe SL, Bhakta K, Gopalakrishnan R. Angioimmunoblastic T-cell lymphoma of the oral cavity presenting as gingival mass: report of the histopathologic and molecular characteristics of an unusual case featuring clonal T-cell receptor ? gene rearrangement by polymerase chain reaction. Oral Surg Oral Med Oral Pathol Oral Radiol 2014;118:e198-204
  • Argyris PP, Nelson AC, Koutlas IK. Keratinizing odontogenic cyst with verrucous pattern featuring negative human papilloma virus status by polymerase chain reaction. Oral Surg Oral Med Oral Pathol Oral Radiol 2014;119:e233-240
  • Capek S, Koutlas IG, Strasia RP, Amrami KK, Spinner RJ. An inferior alveolar intraneural cyst: a case example and an anatomical explanation to support the articular theory within cranial nerves. J Neurosurg 2015;122:1433-1437
  • Argyris PP, McBeain MJT, Rake A, Pambuccian SE, Gopalakrishnan R, Koutlas IG. Recurrent ameloblastoma of the mandible with unusual granular cell component. Int J Surg Pathol 2015;23:298-304
  • Argyris PP, Wetzel SL, Pambuccian SE, Gopalakrishnan R, Koutlas IG. Primordial odontogenic cyst with induction phenomenon (zonal fibroblastic hypercellularity) and dentinoid material versus archegonous cystic odontoma: you choose! Head and Neck Pathol 2016;10:237-44
  • Argyris PP, Anim SO, Koutlas IG. Maxillary pseudotumor as initial manifestation of von Willenbrand disease, type 2. Report of a rare case and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;121:e27-e31
  • Argyris PP, Wetzel SL, Greipp P, Wehrs RN, Knutson DL, Kloft-Nelson SM, García JJ, Koutlas IG. Clinical utility of myb rearrangement detection and p63/p40 immunophenotyping in the diagnosis of adenoid cystic carcinoma of minor salivary glands: a pilot study. [Cover] Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Mar;121:282-9
  • Argyris PP, Wetzel SL, Pambuccian SE, Gopalakrishnan R, Koutlas IG. Response to the Letter Enitled “Archegonous Cystic Odontoma is Not Necessarily Primordial” by Ide et al. Head Neck Pathol 2016;10:422-424
  • Argyris PP, Bilodeau EA, Yancoskie AE, Trochesset D, Pambuccian SE, Wetzel SL, Shah SS, Edelman M, Freedman P, Dolan M, Koutlas IG. A subset of ectomesenchymal chondromyxoid tumors of the tongue shows EWSR1 rearrangements and is genetically linked to soft tissue myoepithelial neoplasms: A study of 11 cases. Histopathol 2016;69:607-613
  • Argyris PP, Koutlas IG. Orthokeratinized odontogenic cyst with an associated keratocystic dontogenic tumor component and ghost cell keratinization and calcifications in a patient with Gardner syndrome. Head Neck Pathol 2017;11:240-248
  • Argyris PP, Anim SO, Koutlas IG. Response to the commentary on "Maxillary pseudotumor as initial manifestation of von Willebrand disease, type 2: report of a rare case and literature review". Oral Surg Oral Med Oral Pathol Oral Radiol 2016;122:260-261
  • Taleb R, Koutlas IG, Argyris PP. Immunohistochemical and histochemical characterization of intraosseous arteriovenous malformations of the jaws: Analysis of 16 cases with emphasis on GLUT-1 immunophenotype. [Cover] Oral Surg Oral Med Oral Pathol Oral Radiol 2017;124:165-174
  • Argyris PP, Gopalakrishnan R, Hu Y, Reichenberger EJ, Koutlas IG. Clinicopathologic and molecular characteristics of familial cherubism with associated odontogenic tumorous proliferations. Head Neck Pathol 2017;12:136-144
  • Dickson BC, Antonescu CR, Argyris PP, Bilodeau E, Bullock MJ, Freedman PD, Lee C-H, Jordan RCK, Iona Leong I, Gnepp DR, Koutlas IG, Merzianu M, Purgina BM, Thompson LDR, Bret Wehrli B, Wright JM, Swanson D, Zhang L, Bishop JA. Ectomesenchymal chondromyxoid tumor: A neoplasm characterized by recurrent RREB1-MKL2 fusions. Am J Surg Pathol 2018;42:1297-1305
  • Argyris PP, Malz C, Taleb R, Koutlas IG. Benign and malignant odontogenic neoplasms of the jaws show a concordant non-discriminatory p63/p40 positive immunophenotype. Oral Surg Oral Med Oral Pathol Oral Radiol 2018;126:506-512
  • Koutlas IG, Dollan M, Lingen MW, Argyris PP. Plasmacytoid cells in salivary pleomorphic adenoma. An alternative interpretation of their immunohistochemical characteristics highlights function and capability for epithelial-mesenchymal transition Oral Surg Oral Med Oral Pathol Oral Radiol 2019; epub ahead of print (February 7)
  • Argyris PP. Slama ZM, Nelson AC, Koutlas IG. Solitary oral epidermolytic acanthoma: Case report of a rarely diagnosed entity. Oral Surg Oral Med Oral Pathol Oral Radiol 2019; epub ahead of print (March 31)
  • Argyris PP, Salma Z, Malz C, Koutlas IG, Pakzad B, Patel K, Kademani D, Khammanivong A, Herzberg MC. Intracellular Calprotectin (S100A8/A9) Associates with Epithelial Differentiation and Promotes Caspase-mediated Cleavage of EGFR in Head and Neck Squamous Cell Carcinoma Oral Oncol; 2019; epub ahead of print (May 27)
  • Argyris PP, Ho D, Nelson AC, Koutlas IG. Pale (clear) cell acanthoma of the palate. Head Neck Pathol; 2019; epub ahead of print (June 22)

Clinical

Board Certifications

Diplomate, The American Board of Oral and Maxillofacial Pathology