Karen F. Ross

Research Associate, Department of Diagnostic and Biological Sciences

Karen F. Ross

Contact Info

rossx007@umn.edu

Office Phone 612-626-1932

Fax 612-626-2651

Office Address:
17-164 Moos Tower
515 Delaware St. SE
Minneapolis, MN 55455

PhD, University of Otago, New Zealand (Microbiology), 1992

Bsc(H), University of Otago, New Zealand (Microbiology), 1987

Post doctorate, University of Minnesota (Molecular Biology), 1992-1996

Research

Research Summary/Interests

Testing the hypothesis that Calprotectin serves as an innate intraepithelial defense against bacterial invasion in vitro and provide evidence for a fundamental role for this protein in resistance to infections. Such knowledge may lead to novel prevention and therapeutic approaches to improve innate defense against pathogens.

Research Funding Grants

NIH/NIDCR

R21 DE015056-01 (Ross)
HIV Modulates Oral Mucosal Calprotectin and Candidiasis
Goal: To determine if HIV infection of oral mucosal epithelial cells will down-regulate calprtoectin causing reduced resistance to Candidal infections.

RO1 DE11831-01-09 (Herzberg)
Innate Intraepithelial Defense Against Oral Infection
Goal: To determine the intracellular trafficking and structural basis for antimicrobial function of the epithelial protein complex, Calprotectin (S100A8/A9).

R01 DE015503-01 (Herzberg)
Oral Epithelial Cells: Innate Immune "Gatekeeper" of HIV
Goal: To identify and profile oral keratinocyte innate immune gene expression in response to HIV and P. gingivalis proteases.

Publications