Isha Mutreja, PhD, MSc

Research Assistant Professor, School of Dentistry

PhD, Biomedical Engineering, Ulster University (United Kingdom)

MSc, Nanoscience, Amity University (India)

Summary

Research

Research Funding Grants

Department of Defense (PROP 2019); ‘‘Bioinspired Acellular Strategies to Optimize the Skin-Implant Interface of Osseointegrated Devices”; ($749,999) [Key Personnel]

University of Otago Research Grant Application (UORG 2017); ''3D breast tumor models for drug discovery; ($36684) [Named Investigator]

COE Strategic Research Grant 2014; ($3000) [PI and Principal Researcher]

Biomolecular Interaction Centre Flagship collaborative grants; Osteogenic differentiation of stem cells using Bioimprinted Surfaces ($3000) [PI and Principal Researcher]

Patents

Adhesive for Osseointegrated Percutaneous Devicses (Provisional Patent Application submitted)

Publications

A novel methacrylate derivative polymer that resists bacterial cell mediated biodegradation, Dhiraj Kumar, Debarati Ghose, Isha Mutreja, Robert D Bolskar, and Robert S Jones. 2021 (Journal, DOI: Submitting). 

Strontium- and peptide-modified silicate nanostructures for dual osteogenic and antimicrobial activity, Isha Mutreja, Dhiraj Kumar, Kami Hogan, Emily Campbell, Kim Mansky, Conrado Aparicio. 2021 (Journal, DOI: Submitting). 

Esterase biodegradation resistance by using a flipped external ester group within a novel methacrylate derivative polymer, Dhiraj Kumar, Debarati Ghose, Robert D Bolskar, Isha Mutreja, Conrado Aparicio, and Robert S Jones. 2021 (Acta Biomaterialia, DOI: Submitted). 

Biomimetic mineralized hybrid scaffolds with antimicrobial peptides. Z Ye, X Zhu, I Mutreja, S Boda, N G Ficher, A Zhang, C Lui, Y Qi and C Aparicio, Bioactive Materials 2021, 6(8): 2250-2260 

A Novel Dental Polymer with a Flipped External Ester Group Design that Resists Degradation via Polymer Backbone Preservation. D Kumar, R D Bolskar, S Malone, I Mutreja, C Aparicio and R S Jones, ACS Biomaterials and Engineering 2020, 6(10): 5609-5619 

Cell responses to titanium and titanium alloys. I Mutreja, Z Ye, C Aparicio, Woodhead Publishing Series in Biomaterials, Handbook of Biomaterials Biocompatibility, imprint of Elseviers, edited by Masoud Mozafari, 2020: 423-452 [ISBN 9780081029671] 

Combined Infection Control and Enhanced Osteogenic Differentiation Capacity on Additive Manufactured Ti-6Al-4V are Mediated via Titania Nanotube Delivery of Novel Biofilm Inhibitors. J Li, I Mutreja, G J Hooper, K Clinch, K S Lim, GB Evans and T B F Woodfield, Advanced Material Interfaces 2020, 7(7): 1901963 (cited – 6) 

Design and characterisation of multi-functional strontium-gelatin nanocomposite bioinks with improved print fidelity and osteogenic capacity. C R Alcala-Orozco, I Mutreja, X Cui, D Kumar, G J Hooper, K S Lim, T B F Woodfield, Bioprinting 2020 18, e00073 (cited – 16) 

Hydrodynamic control of titania nanotube formation on Ti-6Al-4V alloys enhances osteogenic differentiation of human mesenchymal stromal cells. J Li, I Mutreja, S Tredinnick, M Jermy, G J Hooper, T B F Woodfield, Materials Science and Engineering: C 2020 109, 110562 (cited – 7) 

Orthopaedic Osseointegration: Implantology and Future Directions. A L Overmann, C Aparicio, J T Richards, I Mutreja, N G Fischer, S M Wade, B K Potter, T A Davis, J E Bechtold, J A Forsberg, D Dey; Journal of Orthopaedic Research 2019 38(7):1445-1454 (cited – 14) 

Osteogenic and angiogenic tissue formation in high fidelity nanocomposite Laponitegelatin bioinks. G Cidonio, C R Alcala-Orozco, K S Lim, M Glinka, I Mutreja, Y Kim, J I Dawson, T B F Woodfield, R Oreffo; Biofabrication 2019, 11(3) (cited – 47) 

Biofilm inhibition via delivery of novel methylthioadenosine nucleosidase inhibitors from PVA-tyramine hydrogels while supporting mesenchymal stromal cell viability. I Mutreja, S L Warring, K S Lim, T Swadi, K Clinch, J M Mason, C R Sheen, D R Thompson, R G Ducati, S T Chambers, G B Evans, M L Gerth, A G Miller, T B F Woodfield; ACS Biomaterials and Engineering 2018, 5(2): 748 (cited – 5) 

Automated 3D bioassembly of micro-tissues for biofabrication of hybrid tissue engineered constructs. N V Mekhileri, K S Lim, G C J Brown, I Mutreja, B S Schon, G J Hooper, T B F Woodfield; Biofabrication 2018, 10(2): 4103 (cited – 83) 

Cytotoxicity and cellular uptake of different sized gold nanoparticles in ovarian cancer cells, D Kumar, I Mutreja, K Chitcholtan, P Sykes; Nanotechnology, 2017, 28(47):p475101 (cited – 24) 

Seed mediated synthesis of highly mono-dispersed gold nanoparticles in presence of hydroquinone, D Kumar, I Mutreja, P Sykes; Nanotechnology, 2016, 27(35):p. 355601 (cited – 17) 

Fabrication of free-standing casein devices with micro- and nanostructured regular and bioimprinted surface features, A Hashemi, I Mutreja, M M Alkaisi, V Nock, A M Ali; Journal of Vacuum Science and Technology B, 2015, 33:p. 06F901 (cited – 6) 

ORMOSIL nanoparticle Interaction with Macrophage Cells: Assessment of Cell Viability on the Basis of Physico-Chemical Properties of Nanoparticles, D Kumar, I Mutreja, P C Keshvan, M Bhat, A K Dinda, S Mitra; Journal of Pharmaceutical Science, 2015, 104(11):p. 3943-3951 (cited – 11) 

Positive and negative bioimprinted polymeric substrates: new platforms for cell culture, I Mutreja, S Sperling, T B F Woodfield, J J Evans, M M Alkaisi; Biofabrication, 2015,7(2):p. 025002 (cited – 24) 

The Deposition of Strontium-Substituted Hydroxyapatite Coatings, A R Boyd, L Rutledge, I Mutreja, L D Randolph, B J Meenan; Journal of Materials Science: Materials in Medicine, Pharmaceutical Science, 2015, 26(2):p. 65 (cited – 37) 

Enamel proteins mitigate mechanical and structural degradations in mature human enamel during acid attack, G V Lubarsky, P Lemoine, B J Meenan, S Deb, I Mutreja, P Carolan, N Petkov; Materials Research Express, 2014, 1(2) (cited – 12) 

The profile of payload release from gold nanoparticles modified with a BODIPY®/PEG mixed Monolayer, D Kumar, I Mutreja, B J Meenan, D Dixon, Journal of Nano Research, 2013, 25, 16-30 (cited – 6) 

Titania Nanotube Porosity Controls Dissolution Rate of Sputter Deposited Calcium Phosphate (CaP) Thin Film Coatings, I Mutreja, D Kumar, A Boyd and BJ Meenan; RSC Advances, 2013. 3:p. 11263-11273 (cited – 10) 

Controlling the Size and Size Distribution of Gold Nanoparticles: A Design of Experiment Study, D Kumar, B J Meenan, I Mutreja, R D’Sa, D Dixon; International Journal of Nanoscience, 2012. 11:p.1250023-1250030 (cited – 37) 

Modulation of physiochemical properties of Chitosan Nanoparticles prepared by Ionic Gelation and Micro-Emulsion methods, V K Sharma, I Mutreja, S Mitra; International Journal of Nanoscience, 2009. 8:p.191 (cited – 2)