James E. Hinrichs, DDS, MS

Professor, School of Dentistry

James E. Hinrichs

Contact Info


Office Phone 612-625-9107

DDS, University of Nebraska, 1975

MS, University of Nebraska (Periodontology), 1979

University of Nebraska, 1973


Dr. Hinrichs co-authored 21 articles in referred journals and one chapter in a periodontal textbook. He participated in 16 funded research projects while serving as Principal Investigator for 6 of these projects. The research focus has involved clinical diagnostic parameters for periodontal disease including analysis of microbiology, gingival crevicular fluid, subgingival blood flow and more recently periodontal bone regeneration via recombinant human platelet-derived grown factor-BB. He's had the privilege of participating in the 1989, 1996 and 2003 World Workshop in Periodontics as sponsored by the American Academy of Periodontology to author consensus papers on the current state of Periodontics as well as where the field will go in the next decade. As a member of the American Academy of Periodontology's Research Science and Therapy Committee, he co-authored 8 position papers to help set the standards for the profession. He has co-authored 24 abstracts on research projects and has served as a reviewer for the International Journal of Periodontics and Restorative Dentistry as well the Journal of the American Dental Association.


Research Summary/Interests

  • Periodontal regeneration as well as bacterial and genetic risk factors association with periodontitis.
  • Extracrevicular Invasion by Periodontal Pathogens. NIH/NIDCR R01-DE1214-01, 07/01/01-06/30/06. Total direct costs $1,000,000. PI: Joel Rudney (10% effort clinical investigator).
  • Double-Blind, Controlled, Parallel-Arm, Pivotal Human Clinical Trial to Evaluate the Safety and Effectiveness of TCP Plus for the Treatment of Periodontal Bone Defects, 05/01/02-07/01/05. BioMimetic Pharmaceuticals. Amount awarded $95,000. Principal Investigator: James E. Hinrichs (20% effot in 2002, 10% effort in 2003-2005).


1)Kalkwarf, K., Hinrichs, J. and Shaw, D. Management of the dental patient receiving corticosteroid medication. Oral Surgery, Oral Medicine, Oral Pathology 54:396-400, 1982.

2)Bandt, C., Liljemark, W., Pihlstrom, B., Hinrichs, J., Schaffer, E., Wolff, L. The use of selective media for examining the relationship between dental plaque microorganisms and periodontal disease in a large sample clinical investigation. J. Periodont. Res. 17:518-520, 1982.

3)Hinrichs, J., Bandt, C. and Smith, J. Relative error (variability) associated with an improved instrument for measuring gingival crevicular fluid. J. Periodontol. 55:294-298, 1984.

4)Hinrichs, J., Bandt, C., Smith, J. and Golub, L A comparison of three systems for quantitating gingival crevicular fluid with respect to linearity and the effects of qualitative differences in fluids. J. Clin. Periodontol. 11:652-661, 1984.

5)Hinrichs, J., ElDeeb, M., Waite, D., Bevis, R. and Bandt, C A periodontal evaluation of canines erupted through grafted alveolar cleft defects. J. Oral Maxillofac. Surg. 42:717-721, 1984.

6)Hinrichs, J., Wolff, L., Pihlstrom, B., Schaffer, E., Liljemark, W. and Bandt, C. Effects of scaling and root planing on subgingival microbial proportions standardized in terms of their naturally occurring distribution. J. Periodontol. 56:187-194, 1985.

7)Walker, J., Hinrichs, J. and Dyer, J. Phagocytosis of Actinomyces viscosus by murine macrophages. Susceptible and resistant strains. J. Periodont. Res. 20:564-570, 1985.

8)Smith, Q., Hinrichs, J. and Melnyk, R. Gingival crevicular fluid myeloperoxidase at periodontitis sites. J. Periodont. Res. 21:45-55, 1986.

9)ElDeeb, M., Hinrichs, J., Waite. D., Bandt, C. and Bevis, R. Repair of alveolar cleft defects with autogenous bone grafting; periodontal evaluation. J. Cleft Palate 23:126-136, 1986.

10)Hinrichs, J. Hospital Periodontics: A survey of hospital utilization by American Academy of Periodontology members. J. Periodontol. 57:633-671, 1986.

11)Smith Q., Hinrichs J. and Hamilton, M. Phenytoin and 5-(p-hydroxyphenyl)-5-phenylhydantoin do not alter the effects of bacterial and amplified plaque extracts on cultures of fibroblasts from normal and overgrown gingivae. J Dent Res. 66:1393-1398, 1987.

12)Michalowicz, B., Aeppli, D., Virag, J., Klump, D., Hinrichs, J., Segal, N., Bouchard, T. and Pihlstrom, B. Periodontal findings in adult twins. J. Periodontol. 62:293-299, 1991.

13)Liljemark, W., Bloomquist, C., Bandt, C., Pihlstrom, B., Hinrichs, J. and Wolff, L. Comparison of the distribution of Actinomyces in dental plaques on inserted enamel and natural tooth surfaces in periodontal health and disease. Oral Microbiol. Immunol. 8:5-15, 1993.

14)O'Brien, T., Hinrichs, J. and Schaffer, E. The prevention of localized ridge deformaties using guided tissue regeneration. J. Periodontol. 65: 17-24, 1994.

15)Hinrichs, J., LaBelle, L. and Aeppli, D. An evaluation of laser doppler readings obtained within human gingival sulci. J. Periodontol. 66: 171-176, 1995.

16)Hinrichs, J., Jarzembinski, C., Hardie, N. and Aeppli, D. Intrasulcular laser doppler readings before and after root planing. J Clin Periodontol. 22: 817-823, 1995.

17)O'Brien, T., Roszkowski, M., Wolff, L., Hinrichs, J., and Hargraves, K Effect of a non-steroidal anti-inflammatory drug on tissue levels of iPGE2, iLTB4 and pain after periodontal surgery. J Periodontol 67: 1307-1316, 1996.

18)Wolff, L., Kim, A., Nunn, M., Bakdash, B. and Hinrichs, J. Effectiveness of a sonic toothbrush in maintenance of dental implants. A prospective study. J Clin Periodontol. 25: 821-828, 1998.

19)Michalowicz, B., Wolff, L., Klump, D., Hinrichs, J., Aeppli, D., Bouchard, T. and Pihlstrom, B. Periodontal bacteria in adult twins. J Periodontol 70: 263-273, 1999.

20)Klepp M, Schaffer EM, Hinrichs JE, Eastlund T. Histologic evaluation of demineralized freeze-dried bone allografts in barrier membrane covered periodontal fenestration wounds and ectopic sites in dogs. J Clin Periodontol. 31: 534-544, 2004.

21)Nevins, M, Giannobile, W., McGuire, M., Kao, R., Mellonig, J., Hinrichs, J., McAllister, B., Murphy, K., McClain, P., Nevins, M., Paquette, D., Han, T., Reddy, M., Lavin, P., Genco, R., and Lynch, S. Platelet-derived growth factor stimulates bone fill and rate of attachment level gain: results of a large multicenter randomized controlled trial. J Periodontol. 76:2205-2215, 2005.

22)Wohlfahrt, JC, Wu T, Hodges J, Hinrichs J, and Michalowicz M. No association between selected candidate gene polymorphisms and severe chronic periodontitis. J Periodontol. 77:426-436, 2006.

23)Johnson J, Chen R, Lenton P, Zhang G, Hinrichs J and Rudney J: Persistence of Extracrevicular Bacterial Reservoirs After Treatment of Aggressive Periodontitis. J Periodontol 79:2305-2312, 2008.

24)Seong WJ, Conrad HJ and Hinrichs, JE: Potential damage to the bone-implant interface by an implant stability measuring initial implant stability. J Periodontol 80:1868-1874, 2009.

25)Nevins M, Kao R, McGuire M, McClain P, Hinrichs J, Nevins M, Reddy M, Genco R, Lynch S and Giannobile W: PDGF Promotes Periodontal Regeneration in Localized Osseous Defects: 36 Month Extension Results from aRandomized, Controlled, Double-masked Clinical Trial.J Periodontol. 84: 456-464, 2013.

26)Kotsakis G, Chrepa V., Marcou N., Prasad H., Hinrichs J. Flapless alveolar ridge preservation utilizing the ‘’socket-plug’’ technique: clinical technique and review of the literature. Journal of Oral Implantology 40:690-698, 2014.

27)Kotsakis GA, Salama M, Chrepa V, Hinrichs J, and Gaillard P: A randomized, blinded, controlled clinical study of particulate Anorganic Bovine Bone Mineral and Calcium Phosphosilicate Putty bone substitutes for alveolar ridge preservation. Int J Oral Maxillofac Implants. 2014 Jan-Feb;29(1):141-51.

28)Babbush CA, Kanawati A, Kotsakis GA, Hinrichs JE: A financial outcome analysis of conventional implant treatment planning verses the “All-on-4” concept for the rehabilitation of the edentulous jaw. Implant Dentistry. 2014 Apr; 23(2):218-224.

29)Kotsakis GA, Maragkou T, Ioannou A, Romanos G, Hinrichs JE. Prevalence of central maxillary papilla recession and association between papillary recession and interdental smile line: a cross-sectional study. Int J Periodontics Restorative Dentistry 2014; 34(suppl) s81-s87.

30)Ioannou AI, Kotsakis GA, Hinrichs JE. Prognostic factors in periodontal therapy and their association with treatment outcomes. World Journal of Clinical Cases 16:822-827, 2014.

31)Kotsakis GA, Ioannou A, Hinrichs JE, Romanos GA: A systematic review of observational studies evaluating implant placement in the maxillary jaws of medically compromised patients. Clin Impant Dent Relat Res. 17:598-609, 2015.

32)Konstantinides J, Kumar T, Kher U, Stanitsas P, Hinrichs J, Kotsakis GA. Clinical results of implant placement in resorbed ridges using simultaneous guided bone regeneration: A multi-center case series. Clin Oral Investig, 19:553-559, 2015.

33)Ioannou A, Kumar T, Hinrichs J, Kotsakis G and Romanos GE: Evaluation of the bone regeneration potential of bioactive glass in implant site development surgeries: a systematic review. Clin Oral Investig. 19: 181-191, 2015.

34)Kotsakis GA, Javed F, Hinrichs J, Karoussis I, Romanos G. A systematic review and meta-analysis of the impact of cigarette smoking on clinical outcomes following periodontal flap surgicalprocedures. J Periodontol. 86: 254-263, 2015.

35)Hsu A, Seong WJ, Wolff R, Zhang L , Hodges J, Olin P, Hinrichs J. Comparison of initial implant stability placed using bi-cortical fixation , uni-cortical fixation and indirect sinus lift. Accept February 2015. InternationalJournal of Periodontol and Implant Dentistry.

36)Ioannou A, Kotsakis GA, Kumar T, Hinrichs JE, Romanos G. Evaluation of the bone regeneration potential of bioactive glass in implant site development surgeries: a systematic review, Clin Oral Investig. 19:181-191, 2015.

37)Ioannou A, Kotsakis G, McHale M, Lareau D, Hinrichs J and Romanos GE: Soft tissue surgical procedures for optimizing anterior implant esthetics. Accepted June 2015 International Journal of Dentistry

38)Kotsakis G, Prasad H, Rohrer M, Hinrichs J, Boufidou F, Tosios K: Extraction socket management utilizing Platelet-Rich-Fibrin: A proof-of-principle study of the “accelerated-early implant placement” concept. Journal Oral Implantol. 2015 September 21. [Epub ahead of print].

39)Ioannou, Andreas; Koidou, Vasiliki; Kamintzi, Georgia; Hinrichs, James; Kotsakis, George; Romanos, George: Risk Indicators of Papillary Recession in the Anterior Maxilla. Journal of Esthetic and Restorative Dentistry December 2015 [Epub ahead of print].

40)Kovacs A, Hinrichs JE, Kotsakis G: Full-mouth implant rehabilitation in Sjogren’s syndrome with fixed prostheses. In Press January 2016 J Periodontol – Clinical Advances in Periodontics.

41)Lareau DE, Kotsakis GA, Hinrichs JE. Use of connective tissue grafts to enhance root eminence and papilla contour. Accepted for publication in 2016. InternationalJournal of Periodontol and Implant Dentistry.

42)Kotsakis GA, Zermas D, Leroux B, Hinrichs JE: Application of machine learning in periodontal disease classification. Submitted J Periodontol 2016.

43)Kelsey, M, Seong, W, Lunos, S, Hinrichs, J: Prevalence of calculus on implant supported prosthesis and effectiveness of calculus removal. Planned submission to InternationalJournal of Periodontol and Implant Dentistry.

44)Hinrichs J, Dylla R, Sehgal H, Lunos S: Promotion al training in periodontology. Planned submission to J Periodontol.

45)Sehgal H, Lunos S, Hinrichs J: Impact of a periodontal honors course on educational and financial productivity. Planned submission to J Periodontol.

46)Strantzali, V, McAdams, BD, Schilling, J, Lunos, S, Crabb, GW, Kennedy, WR and Hinrichs, JE: Nerve fiber patterns in Periodontitis. Manuscript under final revisions prior to submission to J Periodontol.