Beshay Zordoky, MSc, PhD

Assistant Professor, Department of Experimental and Clinical Pharmacology (ECP)

Beshay Zordoky

Contact Info

zordo001@umn.edu

Office Phone 612-625-6499

Office Address:
3-120 Weaver Densford Hall

Mailing Address:
University of Minnesota College of Pharmacy Department of Experimental and Clinical Pharmacology 7-115 Weaver-Densford Hall 308 Harvard St. SE Minneapolis, MN 55455

University of Alberta, Faculty of Medicine, Cardiovascular Research

University of Alberta, Canada, Pharmaceutical Sciences

Ain Shams University, Egypt, Clinical Pharmacy,

Ain Shams University, Egypt, Pharmacy

Summary

My research focuses on cardio-oncology. Cardio-oncology has emerged as a novel scientific discipline that aims to mitigate the cardiovascular adverse effects of anti-cancer agents. Since the survival of cancer patients has significantly increased over the past two decades, it is very important to improve the quality of life of these cancer survivors.

Awards & Recognition

  • Rally Foundation for Childhood Cancer Research Grant (PI), 2017 - 2018
  • Best Poster Award for Pre-K Scholars, CTSI - University of Minnesota.
  • Special Merit Award for Research Excellence, College of Pharmacy, University of Minnesota.
  • Young Investigator Travel Grant, International Society of Heart Research (ISHR) – North American Section.
  • New Investigator Pre-K Career Development Award, CTSI - University of Minnesota.
  • Clinician Fellowship, Alberta Innovates - Health Solutions.
  • Post-Doctoral Fellowship, Canadian Institutes of Health Research.
  • Pre-Doctoral Dissertation Fellowship, University of Alberta.
  • Alberta Innovates - Health Solutions Studentship.
  • Best Senior Poster Award, Alberta Diabetes Institute.
  • Shoppers Drug Mart Graduate Scholarship in Pharmacy and Pharmaceutical Sciences.
  • Vascular Pharmacology Top Cited Article Award (2008 – 2010).
  • Dr. John Samuel Memorial Graduate Scholarship in Pharmaceutical Sciences.
  • Novartis Pharmaceuticals Inc. Graduate Scholarship in Pharmaceutical Sciences.

Research

Research Summary/Interests

  • Understanding the mechanisms of juvenile doxorubicin-induced cardiotoxicity.
  • Exploring the role of cardiac Cytochrome P450 enzymes in the pathogenesis of delayed doxorubicin-induced cardiotoxicity.

Publications

Grant MKO, Seelig DM, Sharkey LC, and Zordoky BN.* (2017). Sex-dependent alteration of cardiac cytochrome P450 gene expression by doxorubicin in C57Bl/6 mice. Biology of Sex Differences. 8,1. *Corresponding author.

Zordoky BN*, Radin MJ, Heller L, Tobias A, Matise I, Apple FS, McCuneg SA, Sharkey LC. (2016). The interplay between genetic background and sexual dimorphism of doxorubicin-induced cardiotoxicity. Cardio-Oncology. 2 (1), 1. *Corresponding author.

Zordoky BN, Sung MM, Ezekowitz J, Mandal R, Han B, Bjorndahl TC, Bouatra S, Anderson T, Oudit GY, Wishart DS, and Dyck JR. (2015). Metabolomic fingerprint of heart failure with preserved ejection fraction. PLOS One. 26;10(5):e0124844.

Zordoky BN*, Robertson IR*, Dyck JR. (2015). Pre-clinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases. BBA – Molecular Basis of Disease. 1852(6):1155-1177. *Equally contributed to the manuscript.

Zordoky BN*, Nagendran J*, Pulinilkunnil T*, Kienesberger PC, Masson G, Waller TJ, Kemp BE, Steinberg GR, Dyck JRB. (2014). AMPK-dependent inhibitory phosphorylation of ACC is not essential for maintaining myocardial fatty acid oxidation. Circulation Research. 115: 518 - 524. *Equally contributed to the manuscript.

Zordoky BN, Bark D, Soltys CL, Sung MM, Dyck JR. (2014). The anti-proliferative effect of metformin in the triple negative MDA-MB-231 breast cancer cells is highly dependent on glucose concentration: Implications for cancer therapy and prevention. BBA – General Subjects. 1840(6): 1943 – 1957.

Zordoky BN, Anwar-Mohamed A, Aboutabl ME, El-Kadi AO. (2011). Acute doxorubicin toxicity differentially alters cytochrome P450 expression and arachidonic acid metabolism in rat kidney and liver. Drug Metabolism and Disposition. 39(8):1440-50.

Zordoky BN, Anwar-Mohamed A, Aboutabl ME, El-Kadi AO. (2010). Acute doxorubicin cardiotoxicity alters cardiac cytochrome P450 expression and arachidonic acid metabolism in rats. Toxicology and Applied Pharmacology. 1; 242(1):38-46.

Zordoky BN and El-Kadi AO. (2010). Effect of cytochrome P450 polymorphism on arachidonic acid metabolism and their impact on cardiovascular diseases. Pharmacology & Therapeutics. 125(3):446-63.

Zordoky BN*, Aboutabl ME*, and El-Kadi AO. (2008). Modulation of cytochrome P450 gene expression and arachidonic acid metabolism during isoproterenol-induced cardiac hypertrophy in rats. Drug Metabolism and Disposition. 36(11):2277-86. * Equally contributed to the manuscript.

Zordoky BN and El-Kadi AO. (2008). Induction of several cytochrome P450 genes by doxorubicin in H9c2 cells. Vascular Pharmacology. 49(4-6):166-72. Vascular Pharmacology Top Cited Article Award (2008 – 2010).

Zordoky BN and El-Kadi AO. (2007). H9c2 cell line is a valuable in vitro model to study the drug metabolizing enzymes in the heart. Journal of Pharmacological and Toxicological Methods.

Teaching

Courses

PHAR 6732: Medicinal Chemistry and Pharmacology of Cardiovascular Agents.

PHAR 6726: Principles of Pharmacology.

PHAR 6700: Becoming a Pharmacist.