Henning Schroeder, PhD

Special Assistant to the Provost for Professional Education and Professor, Department of Pharmaceutics

Henning Schroeder

Contact Info

schro601@umn.edu

Office Phone 612-625-2809

Office Address:
Grad School Admin
Rm 321 JohH
101 Pleasant St SE
Minneapolis, MN 55455

Mailing Address:
Graduate School
Room 321 JohH
3773A (Campus Delivery Code)
101 Pleasant St SE
Minneapolis, MN 55455

Special Assistant to the Provost for Professional Education and Professor, Department of Pharmaceutics


Fellowship, Stanford University (Cell Signaling), 1986-1987

Doctoral Degree, Düsseldorf University (Pharmacology), 1985

Pharmacy Degree, Düsseldorf University (“Pharmazeutische Prüfung”), 1981

Summary

Positions and Employment:

  • Vice Provost and Dean of Graduate Education, University of Minnesota, 2010
  • Associate Dean for Research and Graduate Studies, College of Pharmacy, University of Minnesota, Minneapolis, 2007
  • Professor, Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, 2007
  • Visiting Professor, Division of Neonatology, Stanford University School of Medicine, California, 2005
  • Professor and Chair, Department of Pharmacology, Martin Luther University School of Pharmacy, Halle, FRG, 1995
  • Visiting Scholar, Division of Oncology, Stanford University School of Medicine, California, 1993
  • Assistant Professor (“Privatdozent”), Department of Pharmacology, Düsseldorf University School of Medicine, FRG, 1992

Awards & Recognition

  • Dean in Residence (NSF, Council of Graduate Schools), 2013
  • Phoenix Pharmaceutical Sciences Award, 2004
  • Fellow of the American Heart Association (F.A.H.A.), 2001
  • Innovation Prize of the Martin Luther University Halle Wittenberg, 1997
  • Heisenberg Fellowship (DFG), 1994
  • DFG visiting scholar fellowship, Stanford University School of Medicine, 1992
  • Edens Prize of the Heinrich Heine University Düsseldorf, 1991
  • DFG postdoctoral fellowship (German Research Foundation), Stanford University School of Medicine, 1986

Research

Research Summary/Interests

Dr. Schroeder’s research focuses on the regulation of antioxidant proteins and their potential role as therapeutic targets in atherosclerosis and other cardiovascular disorders. One of these candidate proteins is heme oxygenase-1 (HO-1) which degrades heme and generates bilirubin and carbon monoxide (CO). Both products have strong antioxidant and anti-inflammatory properties. CO, in addition, acts as a dilator of blood vessels. Dr. Schroeder’s group has shown that HO-1 is a target and mediator of established drugs such as aspirin, the statins, and organic nitrates (nitric oxide donors). More recent work has revealed that bioactive peptides and other micronutrients function as inducers of HO-1 which may explain their antioxidant and antihypertensive properties.

Publications

  • Schröder H (2017) Flags, France and Freedom Fries – the changing flavor of American patriotism. The Society Pages, May 10, 2017 https://thesocietypages.org/holocaust-genocide/flags-france-and-freedom-fries-the-changing-flavor-of-american-patriotism/
  • Schröder H (2016) The unpredictable impacts of international graduate experiences. GradEdge 5 (3):3-4
  • Kartha RV, Zhou J, Basso L, Schröder H, Orchard PJ, Cloyd J (2015) Mechanisms of antioxidant induction with high-dose N-acetylcysteine in childhood cerebral adrenoleukodystrophy. CNS Drugs 29:1041-1047
  • Hetzel S, DeMets D, Schneider R, Borzak S, Schneider W, Serebruany V, Schröder H, Hennekens CH (2013) Aspirin increases nitric oxide formation in chronic stable coronary disease. J Cardiovasc Pharmacol Ther 18:217-221
  • Kartha RV, Zhou J, Hovde LB, Cheung BW and Schröder H. Enhanced detection of hydrogen sulfide generated in cell culture using an agar trap method. Anal. Biochem. 423: 102-108 (2012).
  • Hinkelmann U, Grosser N, Erdmann K, Schröder H and Immenschuh S. Simvastatin-dependent up-regulation of heme oxygenase-1 via mRNA stabilization in human endothelial cells. Eur. J. Pharm. Sci. 41: 118-124 (2010).
  • Sparatore A, Perrino E, Tazzari V, Giustarini D, Rossi R, Rossoni G, Erdmann K, Schröder H and Del Soldato P. Pharmacological profile of a novel hydrogen sulfide-releasing aspirin. Free Radic. Biol. Med. 46: 586-592 (2009).
  • Schröder H. No nitric oxide for HO-1 from sodium nitroprusside. Mol. Pharmacol. 69: 1507-1509 (2006).
  • Schmidt P, Schramm M, Schröder H, Wunder F and Stasch J-P. Identification of residues crucially involved in the binding of the heme moiety of soluble guanylate cyclase. J. Biol. Chem. 279: 3025-3032 (2004).
  • Stasch J-P, Becker EM, Alonso-Alija C, Apeler H, Dembowsky K, Feurer A, Gerzer R, Minuth T, Perzborn E, Pleiss U, Schröder H, Schroeder W, Stahl E, Steinke W, Straub A and Schramm M. NO-independent regulatory site on soluble guanylate cyclase and therapeutic implications. Nature 410: 212-215 (2001).
  • Polte T, Abate A, Dennery PA and Schröder H. Heme oxygenase-1 is a cyclic GMP-inducible endothelial protein and mediates the cytoprotective action of nitric oxide. Arterioscler. Thromb. Vasc. Biol. 20: 1209-1215 (2000).
  • Oberle S, Polte T, Abate A, Podhaisky H-P and Schröder H. Aspirin increases ferritin synthesis in endothelial cells: a novel antioxidant pathway. Circ. Res. 82: 1016-1020 (1998).
  • Schröder H, Leitman DC, Bennett BM, Waldman SA and Murad F. Glyceryl trinitrate-induced desensitization of guanylate cyclase in cultured rat lung fibroblasts. J. Pharmacol. Exp. Ther. 245: 413-418 (1988).