Nam Chul Kim, PhD, MS

Assistant Professor, Department of Pharmacy Practice and Pharmaceutical Sciences

Nam Chul Kim

Contact Info

kimn@d.umn.edu

Office Phone 218-726-6080

Office Address:
121 Life Science

Mailing Address:
University of Minnesota
College of Pharmacy, Duluth
Department of Pharmacy Practice and Pharmaceutical Sciences
232 Life Science
1110 Kirby Drive
Duluth, MN 55812-3003

Administrative Assistant Name
Vicki Everett

Administrative Phone
218-726-7176

Administrative Email
veverett@d.umn.edu

Neuromuscular degeneration, St. Jude Children's Research Hospital, Memphis, TN, USA

PhD, Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL, USA

MS, Department of Life Science, Gwangju Institute of Science and Technology, Korea

BS, Department of Genetic Engineering, SungKyunKwan University, Korea

Post-Doctoral, St.Jude Children’s Research Hospital, Memphis,

TN

Summary

Our research is devoted to develop disease models based on genetic mutations that cause human diseases, and to understand basic molecular pathology using these models. 

To achieve this goal, we use a variety of approaches, including fly genetics, genomics, proteomics, metabolomics and cellular/molecular biology.  The final goal is discovering druggable targets and developing therapeutic strategies in this process. 

 Currently, we focus on age-related neuromuscular degeneration such as amyotrophic lateral sclerosis, frontotemporal dementia and multisystem proteinopathy.

Awards & Recognition

  • 03/1996-02/1998 National Research Assistantship, Ministry of Science and Technology, Korea 
  • 1997 Best Poster Award, Korean Society of Molecular Biology, Korea
  • 2002 Best Research Team Award, Yuhan Research Institute, Yuhan Corporation, Korea
  • 08/2004-07/2006 Study Abroad Support Program, Korea Science and Engineering Foundation, Korea
  • 2007 University of Alabama at Birmingham Graduate Student Association Travel Award

Professional Associations

Society for Developmental Biology, Genetics Society of America

Research

Research Funding Grants

Muscular Dystrophy Association 2016-2019

Publications

PubMed

Badders NM, Korff A, Miranda HC, Vuppala PK, Smith RB, Winborn BJ, Quemin ER, Sopher BL, Dearman J, Messing J, Kim NC, Moore J, Freibaum BD, Kanagaraj AP, Fan B, Tillman H, Chen PC, Wang Y, Freeman BB, Li Y, Kim HJ, La Spada AR, Taylor JP. Selective modulation of the androgen receptor activation function-2 domain rescues degeneration in spinal bulbar muscular atrophy. Nat Med. 2018 May;24(4):427-437. doi: 10.1038/nm.4500

Jones D, Wang X, Shaw T, Cho JH, Chen PC, Kim NC, Taylor JP, Kolli U, Li J, Peng J. (Nature Methods, Submitted), Metabolome Identification by Systematic Stable Isotope Labeling Experiments.

Lee KH*, Zhang P*, Kim HJ*, Mitrea D, Sarkar M, Freibaum B, Cika J, Coughlin M, Messing J, Molliex A, Maxwell B, Kim NC, Temirov J, Moore J, Shaw T, Bai B, Peng J, Kriwacki R, Taylor JP. (2016) Cell, C9orf72 dipeptide repeats impair the assembly, dynamics and function of membrane-less organelles.

Li S, Zhang P, Freibaum BD, Kim NC, Molliex A, Kanagaraj AP, Yabe I, Tanino M, Tanaka S, Sasaki H, Ross ED, Taylor JP, Kim HJ (2016) Hum. Mol. Gen. Mar 1;25(5):936-50, Genetic Interaction of hnRNPA2B1 and DnaJB6 in a Drosophila Model of Multisystem Proteinopathy.

Freibaum B*, Lu Y*, Lopez-Gonzalez R, Kim NC, Almeida S, Lee KH, Valentine M, Miller B, Petrucelli L, Gao FB, Taylor JP. (2015) Nature Sep 3;525(7567):129-33, GGGGCC repeat expansion in C9ORF72 compromises nucleocytoplasmic transport. (* equal contribution)

Kim NC*, Tresse E*, Kolaitis RM, Molliex A, Thomas RE, Alami NH, Wang B, Joshi A, Smith RB, Ritson GP, Winborn BJ, Moore J, Lee JY, Yao TP, Pallanck L, Kundu M, Taylor JP. (2013) Neuron Apr 10;78(1):65-80. VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. (* equal contribution)

Kim HJ*, Kim NC*, Wang YD*, Scarborough EA*, Moore J*, Diaz Z*, MacLea KS, Freibaum B, Li S, Molliex A, Kanagaraj AP, Carter R, Boylan KB, Wojtas AM, Rademakers R, Pinkus JL, Greenberg SA, Trojanowski JQ, Traynor BJ, Smith BN, Topp S, Gkazi AS, Miller J, Shaw CE, Kottlors M, Kirschner J, Pestronk A, Li YR, Ford AF, Gitler AD, Benatar M, King OD, Kimonis VE, Ross ED, Weihl CC, Shorter J, and Taylor JP (2013) Nature Mar 28;495(7442):467-73. Prion-like domain mutations in hnRNPs cause multisystem proteinopathy and ALS (* equal contribution)

Kim NC and Marqués G. (2012) Dev. Neurobiol. 72(12):1541-58. The Ly6 neurotoxin-like molecule target of wit regulates spontaneous neurotransmitter release at the developing neuromuscular junction in Drosophila.

Smith RB, Machamer JB, Kim NC, Hays TS, Marqués G. (2012) J. Cell Sci. 15;125(Pt 16):3752-64. Relay of retrograde synaptogenic signals through axonal transport of BMP receptors.

Kim NC and Marqués G. (2010) Dev. Dyn. 239(9):2413-25. Identification of downstream targets of the Bone Morphogenetic Protein pathway in the Drosophila nervous system

Ye J, Cui X, Loraine A, Bynum K, Kim NC, White G, De Luca M, Garfinkel MD, Lu X, Ruden DM. (2007) Methods Mol. Biol. 371:111-41. Methods for nutrigenomics and longevity studies in Drosophila: effects of diets high in sucrose, palmitic acid, soy, or beef.

Kim NC, Sung SH, Suh DS. (1996) Sungkyunkwn University Life Science Journal 2(2) 67-71. Studies on the Transformation of Killifish using P Vector by Microinjection