Rory Remmel, PhD

Distinguished Teaching Professor, Department of Medicinal Chemistry

Rory Remmel

Contact Info

remme001@umn.edu

Office Phone 612-624-0472

Fax 612-626-3114

Office Address:
8-174 Weaver-Densford Hall

Mailing Address:
University of Minnesota
College of Pharmacy
Department of Medicinal Chemistry
8-101 Weaver-Densford Hall
308 Harvard St. SE
Minneapolis, MN 55455

Distinguished Teaching Professor, Department of Medicinal Chemistry


PhD, Medicinal Chemistry, University of Washington

Bachelor of Pharmacy, University of Wyoming

Summary

Dr. Remmel is a Distinguished Teaching Professor in the College of Pharmacy.

He is well known as a collaborative investigator in drug metabolism research, withan emphasis on glucuronidation. His research has included studies in basic enzymology, work with hepatocytes, animal studies, and clinical studies in AIDS patients, in patients with epilepsy, and in patients with tuberculosis. He has received multiple teaching awards (including highest teaching award given at the University of Minnesota), especially for teaching antimicrobial agents to pharmacy students.

Awards & Recognition

  • Teacher of the Graduating Class of 2012, College of Pharmacy
  • Professor of the Year, Pharm. D III Class in 2001, 2003, 2005, 2007 2008, 2009, 2011
  • Minnesota Alumni Association Outstanding Contributions to Professional and Graduate Education, 2010
  • Outstanding Faculty Award, Council of Graduate Students, 2010

Research

Research Summary/Interests

Research Interests

Drug Metabolism and Disposition, Development of Prodrugs of Carbapenems for Tuberculosis, Metabolism, pharmacokinetics, and pharmacogenomics of antiepileptic Agents, Kinetics of UDP-glucuronosyl transferases, Effect of obesity on drug metabolism and disposition.

Research Projects

Meropenem Prodrugs for Treatment of Multi-Drug-Resistant Tuberculosis, Maternal and Childhood Outcomes of Children Borne by Mothers taking antiepileptic agents during pregnancy, Effect of Obesity on Drug Metabolism and Glucuronidation

Publications

Concentrations in African American Kidney Transplant Recipients Identifies Multiple CYP3A5 Alleles. Am J Transplant. 2016 Feb;16(2):574-82. PMID: 26485092; PMCID:PMC4733408.

Polepally AR, Birnbaum AK, Remmel RP, Rarick JO, Ramsay RE, Steady-state pharmacokinetics and bioavailability of immediate-release and extended-release formulations of lamotrigine in elderly epilepsy patients: Use of stable isotope methodology. J. Clin. Pharmacol. 2015; PMID: 25903807

Polepally AR, Remmel RP, Brundage RC, Leppik IE, Rarick JO, Ramsay RE, Birnbaum AK. Steady-state pharmacokinetics and bioavailability of immediate-release and extended-release formulations of lamotrigine in elderly epilepsy patients: Use of stable isotope methodology. J Clin Pharmacol. 2015 Apr23. doi: 10.1002/jcph.522. [Epub ahead of print] PMID: 25903807.

Pulk RA, Schladt DS, Oetting WS, Guan W, Israni AK, Matas AJ, Remmel RP, Jacobson PA; DeKAF Investigators. Multigene predictors of tacrolimus exposure inkidney transplant recipients. Pharmacogenomics. 2015 ;16(8):841-54. PMCID: PMC4527535.

Pulk RA, Schladt DS, Oetting WS, Guan W, Israni AK, et al.Multigene predictors of tacrolimus exposure in kidney transplant recipients. Pharmacogenomics. 2015; 16(8):841-54. NIHMSID: NIHMS708084 PMID: 26067485 PMCID: PMC4527535

Puranik YG, Birnbaum AK, Marino SE, Ahmed G, Cloyd JC, Remmel RP, Leppik IE, Lamba JK. Association of carbamazepine major metabolism and transport pathway gene polymorphisms and pharmacokinetics in patients with epilepsy.Pharmacogenomics 14(1):35-45(2013). PMID: 23252947

Puranik YG, Birnbaum AK, Marino SE, Ahmed G, Cloyd JC, Remmel RP, Leppik IE, Lamba JK. Association of carbamazepine major metabolism and transport pathway gene polymorphisms and pharmacokinetics in patients with epilepsy. Pharmacogenomics. 2013:35-45. PMCID: PMC3570048.

Sanghavi K, Brundage RC, Miller MB, Schladt DP, Israni AK, Guan W, Oetting WS, Mannon RB, Remmel RP, Matas AJ, Jacobson PA. Genotype-guided tacrolimus dosing inAfrican-American kidney transplant recipients. Pharmacogenomics J. 2015 Dec 15. PMID: 26667830.

Teitelbaum A,Gallardo JL, Bedi J, Giri R, Benoit AR, Olin MR, Morizio KM, Ohlfest J, Remmel RP, Ferguson DF, 9-Amino acridine pharmacokinetics, brain distribution, and in vitro/in vivo efficacy against malignant glioma. Cancer Chemother. Pharmacol. 69(6):1519-27 (2012). PMID: 22402637

Teitelbaum AM, Meissner A, Harding RA, Wong CA, Aldrich CC, Remmel RP.Synthesis, pH-Dependent and Plasma Stability of Meropenem Prodrugs for Potential UseAgainst Drug-Resistant Tuberculosis. Bioorganic Med. Chem. 21(17):5605-5617 (2013). PMID:23845282 PMCID: PMC3740032

Vasan M, Neres J, Williams J, Wilson DJ, Teitelbaum AM, Remmel RP, Aldrich CC. Inhibitors of the salicylate synthase (MbtI) from Mycobacterium tuberculosis discovered by high-throughput screening. ChemMedChem. 5, 2079-2087 (2010). PMID: 21053346

Zhou J, Argikar UA, Remmel RP, Functional Analysis of UGT1A4P24T and UGT1A4L48V variant enzymes for dihydrotestosterone, trans-androsterone, lamotrigine and tamoxifen glucuronidation.Pharmacogenomics 12(12):1671-1679 (2011). PMID:22047493

Zhou J, Tracy TR,Remmel RP.Bilirubin glucuronidation revisited: Proper assay conditions to estimate enzyme kinetics with recombinant UGT1A1.Drug Metab. Disp. 38(11):1907-11 (2010). PMID: 20668247

Zhou J, Tracy TS, Remmel RP. Correlation between bilirubin glucuronidation and estradiol-3-gluronidation in the presence of model UDP-glucuronosyltransferase 1A1 substrates/inhibitors. Drug Metab Dispos. 2011 Feb;39(2):322-9. PMCID: PMC3033692.

Zhou J, Tracy TS, Remmel RP. Correlation between Bilirubin Glucuronidation and Estradiol-3-Gluronidation in the Presence of Model UGT1A1 Substrates/Inhibitors. Drug Metab Dispos. 39(2):322-9 (2011). PMID: 21030469.

Zhou J, Tracy TR,Remmel RP, Glucuronidation of Dihydrotestosterone and Trans-androsterone by Recombinant UGT1A4: Evidence for Multiple UGT1A4 Aglycone Binding Sites.Drug Metab. Disp. 38(3):431-440 (2010) PMID: 20007295

Zhou J, Tracy TS, Remmel RP. Glucuronidation of dihydrotestosterone and trans-androsterone by recombinant UDP-glucuronosyltransferase (UGT) 1A4: evidence for multiple UGT1A4 aglycone binding sites. Drug Metab Dispos. 2010 Mar;38(3):431-40. PMCID: PMC2835394.

See more publications here: http://www.ncbi.nlm.nih.gov/sites/myncbi/rory.remmel.1/bibliography/41154235/public/?sort=date&direction=descending

Clinical

Clinical Interests

Epilepsy; Tuberculosis; Effect of Obesity on Drug Metabolism