Sven-Ulrik Gorr, PhD

Professor, Department of Diagnostic and Biological Sciences

Sven-Ulrik Gorr

Contact Info

sugorr@umn.edu

Office Phone 612-626-5728

Fax 612-625-6948

Office Address:
18-208 Moos Tower
515 Delaware St. SE
Minneapolis, MN 55455

Administrative Assistant Name
Jan Casey

Administrative Phone
612-626-5731

Administrative Email
casey007@umn.edu

PhD, University of Copenhagen (Biochemistry), 1990

Cand. Scient (MSc) Biochemistry, University of Copenhagen, Denmark, 1984

Research

Research Summary/Interests

The long-term goal of our laboratory is to determine the biological role of Parotid Secretory Protein (PSP; BPIFA2) as an oral and systemic anti-inflammatory protein. PSP is expressed in salivary glands, oral epithelial cells and saliva and its expression is up-regulated by bacteria and TNF. An in silico structural analysis of PSP revealed that it may be similar to Bactericidal/Permeability Increasing protein (BPI) and Lipopolysaccharide (LPS)-Binding Protein (LBP). Indeed, recent evidence from our laboratory suggests that PSP binds LPS and prevents systemic inflammation in vivo. Guided by the location of active domains in BPI and LBP, several PSP peptides were designed and found to exhibit both antibacterial and anti-endotoxin activities in vitro and in vivo. Modified PSP peptides have been designed that show enhanced antibacterial activity and selectivity for certain bacterial species. Future goals include understanding the biological activity of PSP in vivo and optimization of PSP peptides as selective antimicrobial peptides with low host toxicity.

Patent: US 8,569,449 B2 Synthetic peptides and peptide mimetics

Publications

  • Hirt H, Gorr SU. Antimicrobial peptide GL13K is effective in reducing biofilms of Pseudomonas aeruginosa. Antimicrob Agents Chemother. 57(10):4903-4910 (2013). PMID:23917321
  • Balhara V, Schmidt R, Gorr SU, Dewolf C. Membrane selectivity and biophysical studies of the antimicrobial peptide GL13K. Biochim Biophys Acta. 1828(9):2193-203. (2013) PMID:2374736
  • Holmberg KV, Abdolhosseini M, Li Y, Chen X, Gorr SU, Aparicio C. Bio-inspired stable antimicrobial peptide coatings for dental applications. Acta Biomater. 9:8224-8231 (2013). PMID:23791670
  • Mestres G, Abdolhosseinin M, Bowles W, Huang SH, Aparicio C, Gorr SU, Ginebra MP. Antimicrobial properties and dentin bonding strength of magnesium phosphate cements. Acta Biomaterialia, 9:8384-8393 (2013). PMID:23747324
  • Horvath S, Nazmul-Hossain AN, Pollard RP, Kroese FG, Vissink A, Kallenberg CG, Spijkervet FK, Bootsma H, Michie SA,Gorr SU, Peck AB, Cai C, Zhou H, Wong DT. Systems analysis of primary Sjögren's syndrome pathogenesis in salivary glands identifies shared pathways in human and a mouse model. Arthritis Res Ther. 14:R238 (2012) . PMID: 23116360
  • Gorr S-U, Wennblom TJ, Horvath S, Wong DTW, Michie SA. Text-mining applied to autoimmune disease research: The Sjogren's Syndrome Knowledge Base. BMC Musculoskeletal Disorders, 13:119 (2012). PMID:22759918
  • Abdolhosseini M, Nandula SR, Song J, Hirt H, Gorr SU. Lysine substitutions convert a bacterial-agglutinating peptide into a bactericidal peptide that retains anti-lipopolysaccharide activity and low hemolytic activity. Peptides. 35:231-238 (2012). PMID:2248428
  • Abdolhosseini M, Sotsky JB, Shelar AP, Joyce PB, Gorr SU. Human parotid secretory protein is a lipopolysaccharide-binding protein: identification of an anti-inflammatory peptide domain. Mol Cell Biochem. 359:1-8 (2012). PMID:21833535
  • Gorr S-U. Antimicrobial peptides in periodontal innate defense, Frontiers in Bioscience, 15: 84-98 (2012). PMID:22142958
  • Biswas S, Knipp RJ, Gordon LE, Nandula SR, Gorr SU, Clark GJ, Nantz MH Hydrophobic Oxime Ethers: A Versatile Class of pDNA and siRNA Transfection Lipids. ChemMedChem. 6: 2063-2069 (2011). PMID:21882348
  • Gorr S-U., Abdolhosseini M., Shelar A., Sotsky, J., Dual host-defence functions of SPLUNC2/PSP and synthetic peptides derived from the protein. Biochemical Society Transactions, 39(4): 1028-1032 (2011). PMID:21787342
  • Gorr S-U, Abdolhosseini M. Antimicrobial peptides and periodontal disease. Journal of Clinical Periodontology, 38 (suppl. 11): 126-141 (2011). PMID:21323710
  • Gorr S-U. Antimicrobial peptides of the oral cavity. Periodontology 2000. 51:152-180 (2009). PMID:19878474
  • Hu S, Zhou M, Jiang J, Wang J, Elashoff D, Gorr S, Michie SA, Spikervet FKL, Bootsma H, Kallenberg CGM, Vissink A, Horvath S, Wong DT. Systems Analysis of Sjögren’s Syndrome and MALT Lymphoma Development in Parotid Glands.Arthritis and Rheumatism, 60:81-92 (2009) PMCID: PMC2718690
  • Gorr S-U, Sotsky JB, Shelar AP, Demuth DR. Design of bacteria-agglutinating peptides derived from Parotid Secretory Protein, a member of the Bactericidal/Permeability Increasing-like protein family. Peptides, 29:2118-2127 (2008) PMID:18952131
  • Kinane, D. F. Galicia, J. Gorr, S. U. Stathopoulou, P. Benakanakere, M. M. P. gingivalis interactions with epithelial cells.Front. Biosci. 13: 966-984 (2008).
  • Fasciotto BH, Kuehn U, Cohn DV, Gorr S-U. Secretory cargo composition affects polarized secretion in MDCK epithelial cells. Mol. Cell. Biochem. 310:67-75 (2008)