Research

Mike T. John, PhD, DDS, MPH

The University of Minnesota School of Dentistry is leading an effort to create a universal tool that can be used internationally to measure patients’ perceived oral health quality. The tool, which will eventually take the form of a patient questionnaire, will one day generate the data needed by providers and researchers to more precisely measure the impact of treatment choices on patient populations.

Bone Cancer Team

Severe pain is a common symptom of many types of bone cancers. As patients and providers seek new treatments for pain that do not involve opioids – which are known to have adverse side effects including addiction - scientists at the University of Minnesota are seeking new solutions.  

Herzberg visual

University of Minnesota researchers have discovered this previously unknown signaling pathway that regulates surface proteins on bacteria that can lead to new targets for antibiotics.

Conrado Aparicio, PhD, MScEng

Conrado Aparicio, PhD, MScEng, is the real deal. He is the consummate educator with superb student evaluations and a mentor of award winning students at all levels of professional education. Lauded by students as “100% good” and “a precious treasure”, he also is universally respected by faculty and colleagues as a scientific pioneer and thought leader with a global reach. 

Keith A. Mays, D.D.S., M.S., Ph.D., Associate Dean for Academic Affairs

The Journal of Dental Education has identified two articles written by School of Dentistry faculty and staff as among its “Most Notable Articles of 2018”. Included on the list of notable articles are:

Conrado Aparicio, PhD, MScEng (Restorative Sci-Biomaterials) and Robert Jones, PhD, DDS (Developmental/Surg Sci- Pediatric Dentistry) have been awarded a two-year subcontract from TDA Research (Wheat Ridge, CO) to collaborate on the development of a novel, long-term stable dental resin polymer system for initial use to improve dental sealants and, later, restorative materials.

Louis M. Mansky, PhD

University of Minnesota researchers in the Institute for Molecular Virology (IMV) have made a key discovery that could have important implications for developing a strategy to stop the spread of a highly infectious virus currently spreading among remote areas of central Australia. Called human T-cell leukemia virus type 1 (HTLV-1), infection rates are reportedly exceeding 40 percent among adults in those communitites. HTLV-1, the first human cancer virus discovered, can cause leukemia and lymphoma.

Galina Yakovlev

Second year University of Minnesota School of Dentistry student Galina Yakovlev was awarded second place in the Student Competition for Advancing Dental Research and its Application (SCADA) for her poster titled "Investigating the effect of PEITC, a natural chemopreventive agent, on the tobacco carcinogen-induced DNA damage in oral cells." She accepted the award at the American Association for Dental Research annual meeting, held March 21-24 in Ft. Lauderdale , Fla.

GL13K graph

At a time when bacteria are increasingly developing an ability to stand up to antibiotics, U-M School of Dentistry scientists have developed an antimicrobial peptide that kills drug resistant bacteria without causing new resistance behaviors.  The new peptide is even effective against bacterial biofilms, a sticky mass of bacteria that are difficult to kill with traditional antibiotics. Bacterial biofilms are responsible for dental plaque and have been estimated to affect 80% of bacterial infections in the body.

Tooth Decay Model

In a new study published in Applied and Environmental Microbiology, an interdisciplinary team of University of Minnesota researchers found some bacteria that absorb and accumulate phosphate from saliva may play a role in tooth decay.

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