Current Studies

Current Studies

All studies have been reviewed and approved by the University of Minnesota’s Institutional Review Board (IRB).

Scaling and root planing (SRP) with and without monocycline spheres

Scaling and root planing (SRP) with and without monocycline spheres

PI: Michelle Arnett RDH, BS, MS

Sponsor: Bausch Health Co.

This randomized clinical trial is comparing scaling and root planning (SRP) with and without minocycline for treatment of periodontitis over a 6-month period. Saliva samples, gingival crevicular fluid (GCF), and blood serum will be collected at four time points (baseline, 1, 3, and 6 month follow up). Saliva will be analyzed for overall pathogen burden. GCF will be analyzed for IL-1, IL-6, and TNF-α. Serum will be analyzed for inflammatory markers.

Timeline:

Qualifying participants will receive a deep cleaning and two teeth cleanings over a six month period at no cost.  There are four visits total that will range from 1-3 hours long, most commonly scheduled on Wednesdays.

Major Inclusion Criteria:

  • Be at least 21 years old
  • Have Periodontitis (gum disease)
  • Need localized or generalized deep teeth cleaning
  • Have a minimum of eight sites with pockets ≥5mm with bleeding on probing
  • Willingness to fulfill all study requirements

Major Exclusion Criteria:

  • Had a localized or generalized deep cleaning in the last six months
  • Cigarette use within the last year
  • Long-term antibiotic use
  • Pregnant, planning to become pregnant, or unsure of pregnancy status and mothers who are breastfeeding
  • Diagnosed cardiac conditions, any uncontrolled medical conditions, or immunocompromised
  • Tetracycline allergy, or taking medication that effects gum tissues

Compensation:

Payment is prorated with $200 available for completion of all study visits.

How to get involved?

Contact:

Michelle Arnett, RDH, BS, MS at marnett@umn.edu or (612) 624-3457, or

Danna Hickey, RDH, MSDH, study coordinator, at hicke097@umn.edu or (612) 626-4744

Prediction of Periodontitis Using NMR Metabolmics

Prediction of Periodontitis Using NMR Metabolmics

PI: Massimo Costalonga DMD, PhD                    Sponsor: Schaffer Chair Fund

This prospective study is assessing the association between the metabolites in the gingival crevicular fluid in patients with periodontitis or peri-implantitis versus controls. Follow-up is done every 6-months over a 2 year period with clinical and radiographic assessment of teeth or implants as well as collection of gingival crevicular fluid.

Timeline: Qualifying individuals will have 4 visit at 6 month intervals for 2 years

At each visit PD measurements will be recorded 

Major Inclusion Criteria:     

  • Subject must be diagnosed with:
  • Periodontitis: must be diagnosed with generalized chronic severe periodontal disease with at least one (1) site with a pocket depth of  ≥ 7 mm with radiographic evidence of 30-50% bone loss.

Or

  • Peri-Implantitis: must be diagnoses with several peri-implantitis (at least one site around the affected implant with a periodontal pocket ≥ 7 mm) and radiographic evidence of at least 30% bone loss (alveolar bone crest be assured from the implant-abutment interface in at least 1 or 2 or more implants present.

Major Exclusion Criteria: 

  • Uncontrolled systemic disease, such as diabetes
  • Systemic antibiotics use within the past 3 months
  • History of periodontal treatment or local antibiotic use in the past 12 months

Compensation:  $35.00 at each visit

How to get involved?

Contact:Patt Carlson GDH, BS, CCRP, study coordinator, at carls006@umn.edu or 612-624-9669

Impact of Brief Motivational Interviewing (BMI) during continuous patient care to enhance oral hygiene

Impact of Brief Motivational Interviewing (BMI) during continuous patient care to enhance oral hygiene

PI: Michelle Arnett RDH, BS, MS

Sponsor: Tenure track start-up fund

This randomized clinical trial is assessing if the utilization of Brief Motivational Interviewing (BMI) during continuous care is superior compared to traditional oral hygiene instructions (OHI) to reduce patients’ plaque score, bleeding on probing (BOP), and gingival index (GI).

This study is no longer recruiting subjects.

Brain Mechanisms Underlying Endogenous Pain Modulation in Chronic TMJD

Brain Mechanisms Underlying Endogenous Pain Modulation in Chronic TMJD

PI: Estephan Moana-Filho DDS, MS, PhD           Sponsor: NIH/NIDCR

The overall goal of this study is to determine brain mechanisms of endogenous pain modulation in chronic TMD pain patients and matched controls using comprehensive phenotyping of clinical and psychosocial characteristics, somatosensory function testing using validated protocol, and multimodal MRI neuroimaging.

Timeline: After a phone screening to identify qualifying individuals the participants will visit the School of Dentistry on three separate occasions. The visits include a comprehensive clinical TMJ examination, sensory/pain testing using touch, pressure, and hot/cold, and a final visit will include a brain MRI scan along with the completion of several questionnaires.

Major Inclusion Criteria:

  • Female between the ages of 18 and 65 years old
  • Must be diagnosed with chronic TMD pain

Major Exclusion Criteria:

  • Current pain medication used that cannot be stopped at least 1 day prior to testing
  • Conditions/diseases that alter pain perception
  • Substance abuse
  • Conditions not allowing the use of an MRI such as claustrophobia or pregnancy
  • Non-English speakers

Compensation: $200.00 to be paid for completion of 3 clinical visits and voucher for parking.

How to get involved?

Contact: Patt Carlson GDH, BS, CCRP, study coordinator, at carls006@umn.edu or 612-624-9669.